Differential control of G0 programme in chronic lymphocytic leukaemia: a novel prognostic factor

Summary Chronic lymphocytic leukaemia (CLL) is a unique malignancy where quiescent B cells accumulate in the peripheral blood. Since clinical outcomes in CLL are very heterogeneous, it is of utmost importance to correctly assess the disease prognosis in each individual case. Recently, it has been sh...

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Veröffentlicht in:	British journal of haematology 2005-02, Vol.128 (4), p.472-481
Hauptverfasser:	Danilov, Alexey V., Klein, Andreas K., Lee, Henry J., Baez, Diana Velez, Huber, Brigitte T.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase - metabolism ADP-ribosyl Cyclase 1 Adult Aged Aged, 80 and over Antigens, CD - metabolism apoptosis Apoptosis - drug effects Biological and medical sciences Biomarkers, Tumor - metabolism Boronic Acids - pharmacology Cell Cycle Cell Death - drug effects chronic lymphocytic leukaemia Dipeptides - pharmacology Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - antagonists & inhibitors Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - physiology Drug Resistance, Neoplasm Enzyme Inhibitors - pharmacology Female Hematologic and hematopoietic diseases Humans Leukemia, Lymphocytic, Chronic, B-Cell - enzymology Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Membrane Glycoproteins Middle Aged Prognosis Protein-Tyrosine Kinases - metabolism Resting Phase, Cell Cycle Tumor Cells, Cultured ZAP-70 Protein-Tyrosine Kinase
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