Synthesis and antibacterial activities of 5-hydroxy-4-amino-2(5 H)-furanones

[Display omitted] Starting from the mucohalogen acids 1a and b 5-hydroxy-2(5 H)-furanones 2a– h have been prepared and tested. These novel 4-amino-5-hydroxy 2(5 H)-furananones have shown a broad antibiotic activity against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas ae...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-02, Vol.15 (4), p.919-921
Hauptverfasser:	Lattmann, Eric, Dunn, Simon, Niamsanit, Suwanna, Sattayasai, Nison
Format:	Artikel
Sprache:	eng
Schlagworte:	2(5 H)-Furanones Anti-Bacterial Agents - chemical synthesis Antibacterial agents Antibacterials Antibiotics. Antiinfectious agents. Antiparasitic agents Bioactivity Biological and medical sciences Drug Resistance, Bacterial Escherichia coli - drug effects Furans - chemical synthesis Furans - pharmacology Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Pseudomonas aeruginosa - drug effects Staphylococcus aureus - drug effects Synthesis
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