Effects of Chronic Administration of Fruit Extract (Citrus unshiu MARC) on Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats
We investigated the effects of chronic administration of fruit extract (Citrus unshiu MARC) on the endothelial dysfunction seen in aortae from streptozotocin (STZ)-induced diabetic rats. A ten-week administration of this fruit extract preserved acetylcholine (ACh)-induced endothelium-dependent relax...
Gespeichert in:
| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2005, Vol.28(2), pp.267-270 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 270 |
|---|---|
| container_issue | 2 |
| container_start_page | 267 |
| container_title | Biological & Pharmaceutical Bulletin |
| container_volume | 28 |
| creator | Kamata, Katsuo Kobayashi, Tsuneo Matsumoto, Takayuki Kanie, Noriyasu Oda, Shu-ichi Kaneda, Akihito Sugiura, Minoru |
| description | We investigated the effects of chronic administration of fruit extract (Citrus unshiu MARC) on the endothelial dysfunction seen in aortae from streptozotocin (STZ)-induced diabetic rats. A ten-week administration of this fruit extract preserved acetylcholine (ACh)-induced endothelium-dependent relaxation, but not sodium nitroprusside (SNP)-induced endothelium-independent relaxation, in the diabetic aorta. In age-matched control rats, chronic administration of the fruit extract had no influence on the ACh- or SNP-induced aortic relaxation. The increased total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride levels seen in STZ-induced diabetic rats were not normalized by fruit-extract treatment. These results suggest that Citrus unshiu MARC extract preserves endothelial function in the aorta in STZ-induced diabetic rats without lowering plasma cholesterol. This beneficial effect may be due to this extract protecting of nitric oxide against inactivation by oxygen free radicals. |
| doi_str_mv | 10.1248/bpb.28.267 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67394256</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3121220111</sourcerecordid><originalsourceid>FETCH-LOGICAL-c685t-1753a1fd18b013f545fc64cadbf79ca8184ebee6d1b4cf709cb14e9a7d87ee7f3</originalsourceid><addsrcrecordid>eNpdkV9rFDEUxYModlt98QNIQBAVZk1mMpPMkyzbbS1UhKrPIZO5cbPMJtv8AduP4Kc2664t-HIDOb-cc8lB6BUlc1oz8XHYDfNazOuOP0Ez2jBetTVtn6IZ6amoOtqKE3Qa44YQwkndPEcntO0EY4LO0O-VMaBTxN7g5Tp4ZzVejFvrbExBJevdXrkI2Sa8-lWudMLvljaFHHF2cW0z_rK4Wb7HBVy50ac1TFZN-Pwumuz0XwPr8LcUYJf8vU9eW1dduTFrGPG5VQOkEnmjUnyBnhk1RXh5PM_Qj4vV9-Xn6vrr5dVycV3pTrSporxtFDUjFQOhjWlZa3THtBoHw3utBBUMBoBupAPThpNeD5RBr_goOAA3zRl6e_DdBX-bISa5tVHDNCkHPkfZ8aZnddsV8M1_4Mbn4MpukjLWN03XE1aoDwdKBx9jACN3wW5VuJOUyH0_svQjayFLPwV-fbTMwxbGR_RYSAEuD0BRrVaTd5N18BisIx-sn7ysCWklIbUgtSSUSVLsy-CE7kvm-70-HZw2Mamf8BClQvnwCR62Oo7y-p-i1ypIcM0fiVm6fA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1449336904</pqid></control><display><type>article</type><title>Effects of Chronic Administration of Fruit Extract (Citrus unshiu MARC) on Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Kamata, Katsuo ; Kobayashi, Tsuneo ; Matsumoto, Takayuki ; Kanie, Noriyasu ; Oda, Shu-ichi ; Kaneda, Akihito ; Sugiura, Minoru</creator><creatorcontrib>Kamata, Katsuo ; Kobayashi, Tsuneo ; Matsumoto, Takayuki ; Kanie, Noriyasu ; Oda, Shu-ichi ; Kaneda, Akihito ; Sugiura, Minoru ; Hoshi University ; Department of Citrus Research ; Okitsu National Institute of Fruit Tree Science ; aDepartment of Physiology and Morphology ; Institute of Medicinal Chemistry ; bLaboratory of Post-Harvest Physiology</creatorcontrib><description>We investigated the effects of chronic administration of fruit extract (Citrus unshiu MARC) on the endothelial dysfunction seen in aortae from streptozotocin (STZ)-induced diabetic rats. A ten-week administration of this fruit extract preserved acetylcholine (ACh)-induced endothelium-dependent relaxation, but not sodium nitroprusside (SNP)-induced endothelium-independent relaxation, in the diabetic aorta. In age-matched control rats, chronic administration of the fruit extract had no influence on the ACh- or SNP-induced aortic relaxation. The increased total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride levels seen in STZ-induced diabetic rats were not normalized by fruit-extract treatment. These results suggest that Citrus unshiu MARC extract preserves endothelial function in the aorta in STZ-induced diabetic rats without lowering plasma cholesterol. This beneficial effect may be due to this extract protecting of nitric oxide against inactivation by oxygen free radicals.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.28.267</identifier><identifier>PMID: 15684481</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>acetylcholine ; Animals ; aorta ; Aorta, Thoracic - drug effects ; Aorta, Thoracic - physiology ; Citrus ; Citrus unshiu ; diabetes ; Diabetes Mellitus, Experimental - diet therapy ; Diabetes Mellitus, Experimental - pathology ; Dose-Response Relationship, Drug ; endothelium ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - pathology ; Endothelium, Vascular - physiology ; Male ; Plant Extracts - administration & dosage ; Rats ; Rats, Wistar ; relaxation ; Vasodilation - drug effects ; Vasodilation - physiology</subject><ispartof>Biological and Pharmaceutical Bulletin, 2005, Vol.28(2), pp.267-270</ispartof><rights>2005 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c685t-1753a1fd18b013f545fc64cadbf79ca8184ebee6d1b4cf709cb14e9a7d87ee7f3</citedby><cites>FETCH-LOGICAL-c685t-1753a1fd18b013f545fc64cadbf79ca8184ebee6d1b4cf709cb14e9a7d87ee7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15684481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamata, Katsuo</creatorcontrib><creatorcontrib>Kobayashi, Tsuneo</creatorcontrib><creatorcontrib>Matsumoto, Takayuki</creatorcontrib><creatorcontrib>Kanie, Noriyasu</creatorcontrib><creatorcontrib>Oda, Shu-ichi</creatorcontrib><creatorcontrib>Kaneda, Akihito</creatorcontrib><creatorcontrib>Sugiura, Minoru</creatorcontrib><creatorcontrib>Hoshi University</creatorcontrib><creatorcontrib>Department of Citrus Research</creatorcontrib><creatorcontrib>Okitsu National Institute of Fruit Tree Science</creatorcontrib><creatorcontrib>aDepartment of Physiology and Morphology</creatorcontrib><creatorcontrib>Institute of Medicinal Chemistry</creatorcontrib><creatorcontrib>bLaboratory of Post-Harvest Physiology</creatorcontrib><title>Effects of Chronic Administration of Fruit Extract (Citrus unshiu MARC) on Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>We investigated the effects of chronic administration of fruit extract (Citrus unshiu MARC) on the endothelial dysfunction seen in aortae from streptozotocin (STZ)-induced diabetic rats. A ten-week administration of this fruit extract preserved acetylcholine (ACh)-induced endothelium-dependent relaxation, but not sodium nitroprusside (SNP)-induced endothelium-independent relaxation, in the diabetic aorta. In age-matched control rats, chronic administration of the fruit extract had no influence on the ACh- or SNP-induced aortic relaxation. The increased total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride levels seen in STZ-induced diabetic rats were not normalized by fruit-extract treatment. These results suggest that Citrus unshiu MARC extract preserves endothelial function in the aorta in STZ-induced diabetic rats without lowering plasma cholesterol. This beneficial effect may be due to this extract protecting of nitric oxide against inactivation by oxygen free radicals.</description><subject>acetylcholine</subject><subject>Animals</subject><subject>aorta</subject><subject>Aorta, Thoracic - drug effects</subject><subject>Aorta, Thoracic - physiology</subject><subject>Citrus</subject><subject>Citrus unshiu</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Experimental - diet therapy</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Dose-Response Relationship, Drug</subject><subject>endothelium</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - pathology</subject><subject>Endothelium, Vascular - physiology</subject><subject>Male</subject><subject>Plant Extracts - administration & dosage</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>relaxation</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilation - physiology</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV9rFDEUxYModlt98QNIQBAVZk1mMpPMkyzbbS1UhKrPIZO5cbPMJtv8AduP4Kc2664t-HIDOb-cc8lB6BUlc1oz8XHYDfNazOuOP0Ez2jBetTVtn6IZ6amoOtqKE3Qa44YQwkndPEcntO0EY4LO0O-VMaBTxN7g5Tp4ZzVejFvrbExBJevdXrkI2Sa8-lWudMLvljaFHHF2cW0z_rK4Wb7HBVy50ac1TFZN-Pwumuz0XwPr8LcUYJf8vU9eW1dduTFrGPG5VQOkEnmjUnyBnhk1RXh5PM_Qj4vV9-Xn6vrr5dVycV3pTrSporxtFDUjFQOhjWlZa3THtBoHw3utBBUMBoBupAPThpNeD5RBr_goOAA3zRl6e_DdBX-bISa5tVHDNCkHPkfZ8aZnddsV8M1_4Mbn4MpukjLWN03XE1aoDwdKBx9jACN3wW5VuJOUyH0_svQjayFLPwV-fbTMwxbGR_RYSAEuD0BRrVaTd5N18BisIx-sn7ysCWklIbUgtSSUSVLsy-CE7kvm-70-HZw2Mamf8BClQvnwCR62Oo7y-p-i1ypIcM0fiVm6fA</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Kamata, Katsuo</creator><creator>Kobayashi, Tsuneo</creator><creator>Matsumoto, Takayuki</creator><creator>Kanie, Noriyasu</creator><creator>Oda, Shu-ichi</creator><creator>Kaneda, Akihito</creator><creator>Sugiura, Minoru</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>Effects of Chronic Administration of Fruit Extract (Citrus unshiu MARC) on Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats</title><author>Kamata, Katsuo ; Kobayashi, Tsuneo ; Matsumoto, Takayuki ; Kanie, Noriyasu ; Oda, Shu-ichi ; Kaneda, Akihito ; Sugiura, Minoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c685t-1753a1fd18b013f545fc64cadbf79ca8184ebee6d1b4cf709cb14e9a7d87ee7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>acetylcholine</topic><topic>Animals</topic><topic>aorta</topic><topic>Aorta, Thoracic - drug effects</topic><topic>Aorta, Thoracic - physiology</topic><topic>Citrus</topic><topic>Citrus unshiu</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Experimental - diet therapy</topic><topic>Diabetes Mellitus, Experimental - pathology</topic><topic>Dose-Response Relationship, Drug</topic><topic>endothelium</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - pathology</topic><topic>Endothelium, Vascular - physiology</topic><topic>Male</topic><topic>Plant Extracts - administration & dosage</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>relaxation</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamata, Katsuo</creatorcontrib><creatorcontrib>Kobayashi, Tsuneo</creatorcontrib><creatorcontrib>Matsumoto, Takayuki</creatorcontrib><creatorcontrib>Kanie, Noriyasu</creatorcontrib><creatorcontrib>Oda, Shu-ichi</creatorcontrib><creatorcontrib>Kaneda, Akihito</creatorcontrib><creatorcontrib>Sugiura, Minoru</creatorcontrib><creatorcontrib>Hoshi University</creatorcontrib><creatorcontrib>Department of Citrus Research</creatorcontrib><creatorcontrib>Okitsu National Institute of Fruit Tree Science</creatorcontrib><creatorcontrib>aDepartment of Physiology and Morphology</creatorcontrib><creatorcontrib>Institute of Medicinal Chemistry</creatorcontrib><creatorcontrib>bLaboratory of Post-Harvest Physiology</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamata, Katsuo</au><au>Kobayashi, Tsuneo</au><au>Matsumoto, Takayuki</au><au>Kanie, Noriyasu</au><au>Oda, Shu-ichi</au><au>Kaneda, Akihito</au><au>Sugiura, Minoru</au><aucorp>Hoshi University</aucorp><aucorp>Department of Citrus Research</aucorp><aucorp>Okitsu National Institute of Fruit Tree Science</aucorp><aucorp>aDepartment of Physiology and Morphology</aucorp><aucorp>Institute of Medicinal Chemistry</aucorp><aucorp>bLaboratory of Post-Harvest Physiology</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Chronic Administration of Fruit Extract (Citrus unshiu MARC) on Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>28</volume><issue>2</issue><spage>267</spage><epage>270</epage><pages>267-270</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>We investigated the effects of chronic administration of fruit extract (Citrus unshiu MARC) on the endothelial dysfunction seen in aortae from streptozotocin (STZ)-induced diabetic rats. A ten-week administration of this fruit extract preserved acetylcholine (ACh)-induced endothelium-dependent relaxation, but not sodium nitroprusside (SNP)-induced endothelium-independent relaxation, in the diabetic aorta. In age-matched control rats, chronic administration of the fruit extract had no influence on the ACh- or SNP-induced aortic relaxation. The increased total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride levels seen in STZ-induced diabetic rats were not normalized by fruit-extract treatment. These results suggest that Citrus unshiu MARC extract preserves endothelial function in the aorta in STZ-induced diabetic rats without lowering plasma cholesterol. This beneficial effect may be due to this extract protecting of nitric oxide against inactivation by oxygen free radicals.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>15684481</pmid><doi>10.1248/bpb.28.267</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 2005, Vol.28(2), pp.267-270 |
| issn | 0918-6158 1347-5215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67394256 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | acetylcholine Animals aorta Aorta, Thoracic - drug effects Aorta, Thoracic - physiology Citrus Citrus unshiu diabetes Diabetes Mellitus, Experimental - diet therapy Diabetes Mellitus, Experimental - pathology Dose-Response Relationship, Drug endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Endothelium, Vascular - physiology Male Plant Extracts - administration & dosage Rats Rats, Wistar relaxation Vasodilation - drug effects Vasodilation - physiology |
| title | Effects of Chronic Administration of Fruit Extract (Citrus unshiu MARC) on Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T15%3A19%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Chronic%20Administration%20of%20Fruit%20Extract%20(Citrus%20unshiu%20MARC)%20on%20Endothelial%20Dysfunction%20in%20Streptozotocin-Induced%20Diabetic%20Rats&rft.jtitle=Biological%20&%20Pharmaceutical%20Bulletin&rft.au=Kamata,%20Katsuo&rft.aucorp=Hoshi%20University&rft.date=2005-02-01&rft.volume=28&rft.issue=2&rft.spage=267&rft.epage=270&rft.pages=267-270&rft.issn=0918-6158&rft.eissn=1347-5215&rft_id=info:doi/10.1248/bpb.28.267&rft_dat=%3Cproquest_cross%3E3121220111%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1449336904&rft_id=info:pmid/15684481&rfr_iscdi=true |