Specific interleukin-1 gene polymorphisms in Turkish patients with Behçet's disease
: Genetic factors that predispose individuals to Behçet's disease (BD) are considered to play important roles in the development of the disease. The pro‐inflammatory cytokine interleukin‐1 (IL‐1) has been implicated in the pathogenesis of BD. Our aim was to determine a possible association of...
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| Veröffentlicht in: | Experimental dermatology 2005-02, Vol.14 (2), p.124-129 |
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| creator | Coskun, Mesut Bacanli, Ali Sallakci, Nilgun Alpsoy, Erkan Yavuzer, Ugur Yegin, Olcay |
| description | : Genetic factors that predispose individuals to Behçet's disease (BD) are considered to play important roles in the development of the disease. The pro‐inflammatory cytokine interleukin‐1 (IL‐1) has been implicated in the pathogenesis of BD. Our aim was to determine a possible association of specific polymorphisms of IL‐1α, IL‐1β, and IL‐1 receptor antagonist genes with susceptibility for BD. We genotyped 72 patients with BD and 163 healthy controls for IL‐1α−889, IL‐1β−511, and +3953 (nt5887) single‐nucleotide polymorphisms besides IL‐1 receptor antagonist variable number of tandem repeat polymorphism (for five different alleles). Comparison of the IL‐1β+3953 T allele and TT genotype frequencies showed a significant difference between patients with BD and controls (54.2 vs. 40.5%, OR = 1.74, P = 0.024, and 40.3 vs. 19.6%, OR = 2.76, P = 0.009, respectively). However, no difference was observed in the genotype or allele frequencies of IL‐1α−889, IL‐1β−511, and IL‐1 receptor antagonist between the patients with BD and the controls. Our results indicate that susceptibility to BD is increased in individuals carrying the IL‐1β+3953 T allele and TT genotype. |
| doi_str_mv | 10.1111/j.0906-6705.2005.00253.x |
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The pro‐inflammatory cytokine interleukin‐1 (IL‐1) has been implicated in the pathogenesis of BD. Our aim was to determine a possible association of specific polymorphisms of IL‐1α, IL‐1β, and IL‐1 receptor antagonist genes with susceptibility for BD. We genotyped 72 patients with BD and 163 healthy controls for IL‐1α−889, IL‐1β−511, and +3953 (nt5887) single‐nucleotide polymorphisms besides IL‐1 receptor antagonist variable number of tandem repeat polymorphism (for five different alleles). Comparison of the IL‐1β+3953 T allele and TT genotype frequencies showed a significant difference between patients with BD and controls (54.2 vs. 40.5%, OR = 1.74, P = 0.024, and 40.3 vs. 19.6%, OR = 2.76, P = 0.009, respectively). However, no difference was observed in the genotype or allele frequencies of IL‐1α−889, IL‐1β−511, and IL‐1 receptor antagonist between the patients with BD and the controls. Our results indicate that susceptibility to BD is increased in individuals carrying the IL‐1β+3953 T allele and TT genotype.</description><identifier>ISSN: 0906-6705</identifier><identifier>EISSN: 1600-0625</identifier><identifier>DOI: 10.1111/j.0906-6705.2005.00253.x</identifier><identifier>PMID: 15679582</identifier><language>eng</language><publisher>Oxford, UK; Malden, USA: Munksgaard International Publishers</publisher><subject>Adult ; Alleles ; Behcet Syndrome - genetics ; Behçet's disease ; Biological and medical sciences ; Case-Control Studies ; Dermatology ; Female ; Gene Frequency ; gene polymorphisms ; Genetic Predisposition to Disease ; Genotype ; Humans ; Interleukin-1 - genetics ; interleukin-1 receptor antagonist genes ; interleukin-1α ; interleukin-1β ; Male ; Medical sciences ; Middle Aged ; Odds Ratio ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Turkey</subject><ispartof>Experimental dermatology, 2005-02, Vol.14 (2), p.124-129</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4343-656159653e18628171dd577afd99cded983e6bd499710adc70c648b99ad02c923</citedby><cites>FETCH-LOGICAL-c4343-656159653e18628171dd577afd99cded983e6bd499710adc70c648b99ad02c923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.0906-6705.2005.00253.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.0906-6705.2005.00253.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>310,311,315,782,786,791,792,1419,23939,23940,25149,27933,27934,45583,45584</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16470653$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15679582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coskun, Mesut</creatorcontrib><creatorcontrib>Bacanli, Ali</creatorcontrib><creatorcontrib>Sallakci, Nilgun</creatorcontrib><creatorcontrib>Alpsoy, Erkan</creatorcontrib><creatorcontrib>Yavuzer, Ugur</creatorcontrib><creatorcontrib>Yegin, Olcay</creatorcontrib><title>Specific interleukin-1 gene polymorphisms in Turkish patients with Behçet's disease</title><title>Experimental dermatology</title><addtitle>Exp Dermatol</addtitle><description>: Genetic factors that predispose individuals to Behçet's disease (BD) are considered to play important roles in the development of the disease. The pro‐inflammatory cytokine interleukin‐1 (IL‐1) has been implicated in the pathogenesis of BD. Our aim was to determine a possible association of specific polymorphisms of IL‐1α, IL‐1β, and IL‐1 receptor antagonist genes with susceptibility for BD. We genotyped 72 patients with BD and 163 healthy controls for IL‐1α−889, IL‐1β−511, and +3953 (nt5887) single‐nucleotide polymorphisms besides IL‐1 receptor antagonist variable number of tandem repeat polymorphism (for five different alleles). Comparison of the IL‐1β+3953 T allele and TT genotype frequencies showed a significant difference between patients with BD and controls (54.2 vs. 40.5%, OR = 1.74, P = 0.024, and 40.3 vs. 19.6%, OR = 2.76, P = 0.009, respectively). However, no difference was observed in the genotype or allele frequencies of IL‐1α−889, IL‐1β−511, and IL‐1 receptor antagonist between the patients with BD and the controls. Our results indicate that susceptibility to BD is increased in individuals carrying the IL‐1β+3953 T allele and TT genotype.</description><subject>Adult</subject><subject>Alleles</subject><subject>Behcet Syndrome - genetics</subject><subject>Behçet's disease</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Dermatology</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>gene polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Interleukin-1 - genetics</subject><subject>interleukin-1 receptor antagonist genes</subject><subject>interleukin-1α</subject><subject>interleukin-1β</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Turkey</subject><issn>0906-6705</issn><issn>1600-0625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM9uFCEcgInR2G31FQwX9TQrDAMMiRetbbVpaqxr6o2w8BuX3fknzKS7T-SD-GIy3U17lQNcvg_4fQhhSuY0rXfrOVFEZEISPs9J2gjJOZtvn6AZFYRkROT8KZo9QEfoOMY1IVQyyZ-jI8qFVLzMZ2jxvQfrK2-xbwcINYwb32YU_4IWcN_Vu6YL_crHJiYAL8aw8XGFezN4aIeI7_ywwh9h9fcPDG8jdj6CifACPatMHeHl4TxBP87PFqefs6uvF19OP1xltmAFywQXlCvBGdBS5CWV1DkupamcUtaBUyUDsXSFUpIS46wkVhTlUinjSG5Vzk7Qm_29feh-jxAH3fhooa5NC90YtZAsUZQksNyDNnQxBqh0H3xjwk5Toqeieq2nWHqKpaei-r6o3ib11eGNcdmAexQPCRPw-gCYaE1dBdNaHx85UUiSZkzc-z1352vY_fcH9NnPT_m9nu11HwfYPugmbKYxJde31xf68vKWfbu5KfQ1-wfDPqDG</recordid><startdate>200502</startdate><enddate>200502</enddate><creator>Coskun, Mesut</creator><creator>Bacanli, Ali</creator><creator>Sallakci, Nilgun</creator><creator>Alpsoy, Erkan</creator><creator>Yavuzer, Ugur</creator><creator>Yegin, Olcay</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200502</creationdate><title>Specific interleukin-1 gene polymorphisms in Turkish patients with Behçet's disease</title><author>Coskun, Mesut ; Bacanli, Ali ; Sallakci, Nilgun ; Alpsoy, Erkan ; Yavuzer, Ugur ; Yegin, Olcay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4343-656159653e18628171dd577afd99cded983e6bd499710adc70c648b99ad02c923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Behcet Syndrome - genetics</topic><topic>Behçet's disease</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Dermatology</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>gene polymorphisms</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Interleukin-1 - genetics</topic><topic>interleukin-1 receptor antagonist genes</topic><topic>interleukin-1α</topic><topic>interleukin-1β</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coskun, Mesut</creatorcontrib><creatorcontrib>Bacanli, Ali</creatorcontrib><creatorcontrib>Sallakci, Nilgun</creatorcontrib><creatorcontrib>Alpsoy, Erkan</creatorcontrib><creatorcontrib>Yavuzer, Ugur</creatorcontrib><creatorcontrib>Yegin, Olcay</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coskun, Mesut</au><au>Bacanli, Ali</au><au>Sallakci, Nilgun</au><au>Alpsoy, Erkan</au><au>Yavuzer, Ugur</au><au>Yegin, Olcay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific interleukin-1 gene polymorphisms in Turkish patients with Behçet's disease</atitle><jtitle>Experimental dermatology</jtitle><addtitle>Exp Dermatol</addtitle><date>2005-02</date><risdate>2005</risdate><volume>14</volume><issue>2</issue><spage>124</spage><epage>129</epage><pages>124-129</pages><issn>0906-6705</issn><eissn>1600-0625</eissn><abstract>: Genetic factors that predispose individuals to Behçet's disease (BD) are considered to play important roles in the development of the disease. The pro‐inflammatory cytokine interleukin‐1 (IL‐1) has been implicated in the pathogenesis of BD. Our aim was to determine a possible association of specific polymorphisms of IL‐1α, IL‐1β, and IL‐1 receptor antagonist genes with susceptibility for BD. We genotyped 72 patients with BD and 163 healthy controls for IL‐1α−889, IL‐1β−511, and +3953 (nt5887) single‐nucleotide polymorphisms besides IL‐1 receptor antagonist variable number of tandem repeat polymorphism (for five different alleles). Comparison of the IL‐1β+3953 T allele and TT genotype frequencies showed a significant difference between patients with BD and controls (54.2 vs. 40.5%, OR = 1.74, P = 0.024, and 40.3 vs. 19.6%, OR = 2.76, P = 0.009, respectively). However, no difference was observed in the genotype or allele frequencies of IL‐1α−889, IL‐1β−511, and IL‐1 receptor antagonist between the patients with BD and the controls. Our results indicate that susceptibility to BD is increased in individuals carrying the IL‐1β+3953 T allele and TT genotype.</abstract><cop>Oxford, UK; Malden, USA</cop><pub>Munksgaard International Publishers</pub><pmid>15679582</pmid><doi>10.1111/j.0906-6705.2005.00253.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Experimental dermatology, 2005-02, Vol.14 (2), p.124-129 |
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| subjects | Adult Alleles Behcet Syndrome - genetics Behçet's disease Biological and medical sciences Case-Control Studies Dermatology Female Gene Frequency gene polymorphisms Genetic Predisposition to Disease Genotype Humans Interleukin-1 - genetics interleukin-1 receptor antagonist genes interleukin-1α interleukin-1β Male Medical sciences Middle Aged Odds Ratio Polymorphism, Genetic Polymorphism, Single Nucleotide Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Turkey |
| title | Specific interleukin-1 gene polymorphisms in Turkish patients with Behçet's disease |
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