Safety and intestinal tolerance of high-dose enteral antioxidants and glutamine peptides after upper gastrointestinal surgery
Objective: Safety and intestinal tolerance of an early high-dose enteral administration of antioxidative vitamins, trace elements, and glutamine dipeptides. Design: open intervention trial. Setting: Two university teaching hospitals. Patients: A total of 14 patients requiring jejunal feeding (64+/-1...
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| Veröffentlicht in: | European journal of clinical nutrition 2005-02, Vol.59 (2), p.307-310 |
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| creator | Schroeder, J Alteheld, B Stehle, P Cayeux, M.C Chiolero, R.L Berger, M.M |
| description | Objective: Safety and intestinal tolerance of an early high-dose enteral administration of antioxidative vitamins, trace elements, and glutamine dipeptides. Design: open intervention trial. Setting: Two university teaching hospitals. Patients: A total of 14 patients requiring jejunal feeding (64+/-14 y). Intervention: A measure of 500 ml/day Intestamin (FreseniusKabi: 250 kcal/1.050 kJ, 300 microgram selenium, 20 mg zinc, 400 microgram chromium, 1500 mg vitamin C, 500 mg vitamin E, 10 mg β-carotene, 30 g glutamine) for 5 days beginning 6 h after surgery. Parenteral/enteral nutrition was provided to achieve energy target (25 kcal/kg/day). Assessments: Intestinal complaints, plasma nutrients, and glutathione. Results: Only minor signs of nausea, hiccups, flatulence (3/14). Plasma micronutrients (except β-carotene) postoperatively decreased and increased to normal on day 5. Extracellular glutamine remained low (preop: 520+/-94; d1: 357+/-67; d5: 389+/-79 micromol/l); total glutathione decreased (d1: 9.4+/-3.8; d5: 3.6+/-2.5 micromol/l). Conclusion: Study feed is well tolerated and metabolically safe representing a valuable tool for targeted pharmaconutrient supply. |
| doi_str_mv | 10.1038/sj.ejcn.1602073 |
| format | Article |
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Design: open intervention trial. Setting: Two university teaching hospitals. Patients: A total of 14 patients requiring jejunal feeding (64+/-14 y). Intervention: A measure of 500 ml/day Intestamin (FreseniusKabi: 250 kcal/1.050 kJ, 300 microgram selenium, 20 mg zinc, 400 microgram chromium, 1500 mg vitamin C, 500 mg vitamin E, 10 mg β-carotene, 30 g glutamine) for 5 days beginning 6 h after surgery. Parenteral/enteral nutrition was provided to achieve energy target (25 kcal/kg/day). Assessments: Intestinal complaints, plasma nutrients, and glutathione. Results: Only minor signs of nausea, hiccups, flatulence (3/14). Plasma micronutrients (except β-carotene) postoperatively decreased and increased to normal on day 5. Extracellular glutamine remained low (preop: 520+/-94; d1: 357+/-67; d5: 389+/-79 micromol/l); total glutathione decreased (d1: 9.4+/-3.8; d5: 3.6+/-2.5 micromol/l). Conclusion: Study feed is well tolerated and metabolically safe representing a valuable tool for targeted pharmaconutrient supply.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/sj.ejcn.1602073</identifier><identifier>PMID: 15508015</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antioxidants ; Antioxidants - administration & dosage ; Antioxidants - metabolism ; Ascorbic acid ; Biological and medical sciences ; Carotene ; Chromium ; Clinical nutrition ; Clinical trials ; dietary mineral supplements ; dietary minerals ; dietary supplements ; Digestive system ; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition ; enteral feeding ; Enteral Nutrition ; Female ; Food, Formulated - adverse effects ; Gastrointestinal Neoplasms - surgery ; Gastrointestinal Neoplasms - therapy ; Glutamine ; Glutamine - administration & dosage ; Glutamine - metabolism ; Glutathione ; Hospitals ; human health ; Human resources ; Humans ; Intensive care medicine ; Intestinal Absorption ; Intestine ; intestines ; Jejunostomy ; Male ; Medical sciences ; megadose ; Micronutrients ; Middle Aged ; Nausea ; nutrient intake ; Nutrients ; Nutrition ; nutritional intervention ; Parenteral nutrition ; Patients ; Peptides ; Postoperative Care - methods ; Safety ; Selenium ; Surgery ; Time Factors ; Trace elements ; Trace elements (nutrients) ; Trace Elements - administration & dosage ; Trace Elements - metabolism ; Treatment Outcome ; Vitamin E ; vitamin supplements ; Vitamins ; zinc ; β-Carotene</subject><ispartof>European journal of clinical nutrition, 2005-02, Vol.59 (2), p.307-310</ispartof><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Macmillan Journals Ltd. Feb 2005</rights><rights>Nature Publishing Group 2005.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-61ccdbc880e8f3b82fb3de09fc2c31ef54c1b1e4a528219028a5dfecbb7c60323</citedby><cites>FETCH-LOGICAL-c575t-61ccdbc880e8f3b82fb3de09fc2c31ef54c1b1e4a528219028a5dfecbb7c60323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,2731,27933,27934</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16524451$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15508015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schroeder, J</creatorcontrib><creatorcontrib>Alteheld, B</creatorcontrib><creatorcontrib>Stehle, P</creatorcontrib><creatorcontrib>Cayeux, M.C</creatorcontrib><creatorcontrib>Chiolero, R.L</creatorcontrib><creatorcontrib>Berger, M.M</creatorcontrib><title>Safety and intestinal tolerance of high-dose enteral antioxidants and glutamine peptides after upper gastrointestinal surgery</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><description>Objective: Safety and intestinal tolerance of an early high-dose enteral administration of antioxidative vitamins, trace elements, and glutamine dipeptides. Design: open intervention trial. Setting: Two university teaching hospitals. Patients: A total of 14 patients requiring jejunal feeding (64+/-14 y). Intervention: A measure of 500 ml/day Intestamin (FreseniusKabi: 250 kcal/1.050 kJ, 300 microgram selenium, 20 mg zinc, 400 microgram chromium, 1500 mg vitamin C, 500 mg vitamin E, 10 mg β-carotene, 30 g glutamine) for 5 days beginning 6 h after surgery. Parenteral/enteral nutrition was provided to achieve energy target (25 kcal/kg/day). Assessments: Intestinal complaints, plasma nutrients, and glutathione. Results: Only minor signs of nausea, hiccups, flatulence (3/14). Plasma micronutrients (except β-carotene) postoperatively decreased and increased to normal on day 5. Extracellular glutamine remained low (preop: 520+/-94; d1: 357+/-67; d5: 389+/-79 micromol/l); total glutathione decreased (d1: 9.4+/-3.8; d5: 3.6+/-2.5 micromol/l). Conclusion: Study feed is well tolerated and metabolically safe representing a valuable tool for targeted pharmaconutrient supply.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - metabolism</subject><subject>Ascorbic acid</subject><subject>Biological and medical sciences</subject><subject>Carotene</subject><subject>Chromium</subject><subject>Clinical nutrition</subject><subject>Clinical trials</subject><subject>dietary mineral supplements</subject><subject>dietary minerals</subject><subject>dietary supplements</subject><subject>Digestive system</subject><subject>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</subject><subject>enteral feeding</subject><subject>Enteral Nutrition</subject><subject>Female</subject><subject>Food, Formulated - adverse effects</subject><subject>Gastrointestinal Neoplasms - surgery</subject><subject>Gastrointestinal Neoplasms - therapy</subject><subject>Glutamine</subject><subject>Glutamine - administration & dosage</subject><subject>Glutamine - metabolism</subject><subject>Glutathione</subject><subject>Hospitals</subject><subject>human health</subject><subject>Human resources</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Intestinal Absorption</subject><subject>Intestine</subject><subject>intestines</subject><subject>Jejunostomy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>megadose</subject><subject>Micronutrients</subject><subject>Middle Aged</subject><subject>Nausea</subject><subject>nutrient intake</subject><subject>Nutrients</subject><subject>Nutrition</subject><subject>nutritional intervention</subject><subject>Parenteral nutrition</subject><subject>Patients</subject><subject>Peptides</subject><subject>Postoperative Care - methods</subject><subject>Safety</subject><subject>Selenium</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Trace elements</subject><subject>Trace elements (nutrients)</subject><subject>Trace Elements - administration & dosage</subject><subject>Trace Elements - metabolism</subject><subject>Treatment Outcome</subject><subject>Vitamin E</subject><subject>vitamin supplements</subject><subject>Vitamins</subject><subject>zinc</subject><subject>β-Carotene</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10s1v0zAUAPAIgVgZnDkBERO7pfNH7DjHaYKBNInD2NlynOfUVWoH25HWA_877lq0goYsxZLf7z079iuKtxgtMaLiIq6XsNZuiTkiqKHPigWuG14xXqPnxQK1rK4oQs1J8SrGNUI52JCXxQlmDAmE2aL4dasMpG2pXF9alyAm69RYJj9CUE5D6U25ssOq6n2EErIIOaxcsv7e9nmOD6nDOCe1sQ7KCaZke8jLJttynqb8HVRMwR_Vj3MYIGxfFy-MGiO8Ocynxd2Xzz-uvlY336-_XV3eVJo1LFUca913WggEwtBOENPRHlBrNNEUg2G1xh2GWjEiCG4REYr1BnTXNZojSuhpcb6vOwX_c86HkBsbNYyjcuDnKHlDW8wJz_DsH7j2c8gnjpLwmuQ7q7HI6uN_FW4550jgjKo9GtQI0jrjU1B6ALe7Qe_A2Lx8iVvWNBQ_-OUTPo8eNlY_mXB-lLACNaZV9PkhrHfxb3ixhzr4GAMYOQW7UWErMZK7NpJxLXdtJA9tlDPeH35w7jbQP_pD32Tw6QBU1Go0u16x8dFxRuqa7bZ-t3dOpTnAEfiz0Yd93Cgv1RByjbtbgjBFGOGWMEF_A2gk5Lo</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Schroeder, J</creator><creator>Alteheld, B</creator><creator>Stehle, P</creator><creator>Cayeux, M.C</creator><creator>Chiolero, R.L</creator><creator>Berger, M.M</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>Safety and intestinal tolerance of high-dose enteral antioxidants and glutamine peptides after upper gastrointestinal surgery</title><author>Schroeder, J ; Alteheld, B ; Stehle, P ; Cayeux, M.C ; Chiolero, R.L ; Berger, M.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-61ccdbc880e8f3b82fb3de09fc2c31ef54c1b1e4a528219028a5dfecbb7c60323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antioxidants</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - metabolism</topic><topic>Ascorbic acid</topic><topic>Biological and medical sciences</topic><topic>Carotene</topic><topic>Chromium</topic><topic>Clinical nutrition</topic><topic>Clinical trials</topic><topic>dietary mineral supplements</topic><topic>dietary minerals</topic><topic>dietary supplements</topic><topic>Digestive system</topic><topic>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</topic><topic>enteral feeding</topic><topic>Enteral Nutrition</topic><topic>Female</topic><topic>Food, Formulated - adverse effects</topic><topic>Gastrointestinal Neoplasms - surgery</topic><topic>Gastrointestinal Neoplasms - therapy</topic><topic>Glutamine</topic><topic>Glutamine - administration & dosage</topic><topic>Glutamine - metabolism</topic><topic>Glutathione</topic><topic>Hospitals</topic><topic>human health</topic><topic>Human resources</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Intestinal Absorption</topic><topic>Intestine</topic><topic>intestines</topic><topic>Jejunostomy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>megadose</topic><topic>Micronutrients</topic><topic>Middle Aged</topic><topic>Nausea</topic><topic>nutrient intake</topic><topic>Nutrients</topic><topic>Nutrition</topic><topic>nutritional intervention</topic><topic>Parenteral nutrition</topic><topic>Patients</topic><topic>Peptides</topic><topic>Postoperative Care - methods</topic><topic>Safety</topic><topic>Selenium</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Trace elements</topic><topic>Trace elements (nutrients)</topic><topic>Trace Elements - administration & dosage</topic><topic>Trace Elements - metabolism</topic><topic>Treatment Outcome</topic><topic>Vitamin E</topic><topic>vitamin supplements</topic><topic>Vitamins</topic><topic>zinc</topic><topic>β-Carotene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schroeder, J</creatorcontrib><creatorcontrib>Alteheld, B</creatorcontrib><creatorcontrib>Stehle, P</creatorcontrib><creatorcontrib>Cayeux, M.C</creatorcontrib><creatorcontrib>Chiolero, R.L</creatorcontrib><creatorcontrib>Berger, M.M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schroeder, J</au><au>Alteheld, B</au><au>Stehle, P</au><au>Cayeux, M.C</au><au>Chiolero, R.L</au><au>Berger, M.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety and intestinal tolerance of high-dose enteral antioxidants and glutamine peptides after upper gastrointestinal surgery</atitle><jtitle>European journal of clinical nutrition</jtitle><addtitle>Eur J Clin Nutr</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>59</volume><issue>2</issue><spage>307</spage><epage>310</epage><pages>307-310</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Objective: Safety and intestinal tolerance of an early high-dose enteral administration of antioxidative vitamins, trace elements, and glutamine dipeptides. Design: open intervention trial. Setting: Two university teaching hospitals. Patients: A total of 14 patients requiring jejunal feeding (64+/-14 y). Intervention: A measure of 500 ml/day Intestamin (FreseniusKabi: 250 kcal/1.050 kJ, 300 microgram selenium, 20 mg zinc, 400 microgram chromium, 1500 mg vitamin C, 500 mg vitamin E, 10 mg β-carotene, 30 g glutamine) for 5 days beginning 6 h after surgery. Parenteral/enteral nutrition was provided to achieve energy target (25 kcal/kg/day). Assessments: Intestinal complaints, plasma nutrients, and glutathione. Results: Only minor signs of nausea, hiccups, flatulence (3/14). Plasma micronutrients (except β-carotene) postoperatively decreased and increased to normal on day 5. Extracellular glutamine remained low (preop: 520+/-94; d1: 357+/-67; d5: 389+/-79 micromol/l); total glutathione decreased (d1: 9.4+/-3.8; d5: 3.6+/-2.5 micromol/l). Conclusion: Study feed is well tolerated and metabolically safe representing a valuable tool for targeted pharmaconutrient supply.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>15508015</pmid><doi>10.1038/sj.ejcn.1602073</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antioxidants Antioxidants - administration & dosage Antioxidants - metabolism Ascorbic acid Biological and medical sciences Carotene Chromium Clinical nutrition Clinical trials dietary mineral supplements dietary minerals dietary supplements Digestive system Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition enteral feeding Enteral Nutrition Female Food, Formulated - adverse effects Gastrointestinal Neoplasms - surgery Gastrointestinal Neoplasms - therapy Glutamine Glutamine - administration & dosage Glutamine - metabolism Glutathione Hospitals human health Human resources Humans Intensive care medicine Intestinal Absorption Intestine intestines Jejunostomy Male Medical sciences megadose Micronutrients Middle Aged Nausea nutrient intake Nutrients Nutrition nutritional intervention Parenteral nutrition Patients Peptides Postoperative Care - methods Safety Selenium Surgery Time Factors Trace elements Trace elements (nutrients) Trace Elements - administration & dosage Trace Elements - metabolism Treatment Outcome Vitamin E vitamin supplements Vitamins zinc β-Carotene |
| title | Safety and intestinal tolerance of high-dose enteral antioxidants and glutamine peptides after upper gastrointestinal surgery |
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