Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease

Mutations in the leucine-rich repeat kinase 2 ( LRRK2) gene cause some forms of autosomal dominant Parkinson's disease. We measured the frequency of a novel mutation (Gly2019Ser) in familial Parkinson's disease by screening genomic DNA of patients and controls. Of 767 affected individuals...

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Veröffentlicht in:	The Lancet (British edition) 2005-01, Vol.365 (9457), p.410-412
Hauptverfasser:	Nichols, William C, Pankratz, Nathan, Hernandez, Dena, Paisán-Ruíz, Coro, Jain, Shushant, Halter, Cheryl A, Michaels, Veronika E, Reed, Terry, Rudolph, Alice, Shults, Clifford W, Singleton, Andrew, Foroud, Tatiana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Deoxyribonucleic acid DNA Genetic Predisposition to Disease Genetic screening Genetic Testing Genomics Genotype Heterozygote Homozygote Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Male Middle Aged Mutation Parkinson Disease - genetics Parkinson's disease Point Mutation Protein-Serine-Threonine Kinases - genetics
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