Neurochemical analysis of rat strain differences in the startle gating-disruptive effects of dopamine agonists
The disruption of prepulse inhibition (PPI) in rats by dopamine (DA) agonists is used to study the neural basis of strain differences in dopaminergic function. We reported that, compared to Long–Evans (LEH) rats, Sprague–Dawley (SDH) rats are more sensitive to the PPI-disruptive effects of the direc...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2005-02, Vol.80 (2), p.203-211 |
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| creator | Swerdlow, Neal R. Kuczenski, Ronald Goins, Jana C. Crain, Sarah K. Ma, Lillian T. Bongiovanni, Michele J. Shoemaker, Jody M. |
| description | The disruption of prepulse inhibition (PPI) in rats by dopamine (DA) agonists is used to study the neural basis of strain differences in dopaminergic function. We reported that, compared to Long–Evans (LEH) rats, Sprague–Dawley (SDH) rats are more sensitive to the PPI-disruptive effects of the direct D1/D2 agonist apomorphine (APO) and the indirect DA agonist d-amphetamine (AMPH). This strain difference is heritable, with PPI drug sensitivity following a generational pattern (SDH>N2>F1>LEH) suggestive of additive effects of multiple genes. Here, we assessed the neurochemical bases for these heritable strain differences by measuring tissue levels of dopamine, serotonin (5HT) and their respective metabolites in several forebrain regions after vehicle, APO or AMPH administration. SDH rats were more sensitive than LEH rats to the PPI-disruptive effects of both APO (0.5 mg/kg) and AMPH (4.5 mg/kg). Several significant SDH vs. LEH strain differences in regional neurochemical levels were detected, as were drug effects on these chemicals. However, SDH, LEH and F1 rats did not exhibit differential drug sensitivity in any neurochemical indices measures. These findings suggest that inherited differences in the dopaminergic regulation of sensorimotor gating do not likely reflect differences in presynaptic forebrain dopaminergic or serotonergic processes. |
| doi_str_mv | 10.1016/j.pbb.2004.11.002 |
| format | Article |
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We reported that, compared to Long–Evans (LEH) rats, Sprague–Dawley (SDH) rats are more sensitive to the PPI-disruptive effects of the direct D1/D2 agonist apomorphine (APO) and the indirect DA agonist d-amphetamine (AMPH). This strain difference is heritable, with PPI drug sensitivity following a generational pattern (SDH>N2>F1>LEH) suggestive of additive effects of multiple genes. Here, we assessed the neurochemical bases for these heritable strain differences by measuring tissue levels of dopamine, serotonin (5HT) and their respective metabolites in several forebrain regions after vehicle, APO or AMPH administration. SDH rats were more sensitive than LEH rats to the PPI-disruptive effects of both APO (0.5 mg/kg) and AMPH (4.5 mg/kg). Several significant SDH vs. LEH strain differences in regional neurochemical levels were detected, as were drug effects on these chemicals. However, SDH, LEH and F1 rats did not exhibit differential drug sensitivity in any neurochemical indices measures. These findings suggest that inherited differences in the dopaminergic regulation of sensorimotor gating do not likely reflect differences in presynaptic forebrain dopaminergic or serotonergic processes.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/j.pbb.2004.11.002</identifier><identifier>PMID: 15680173</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>3,4-Dihydroxyphenylacetic Acid - metabolism ; Amphetamine ; Animals ; Apomorphine ; Behavioral psychophysiology ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Dopamine ; Dopamine - genetics ; Dopamine - metabolism ; Dopamine Agonists - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Male ; Medial prefrontal cortex ; Neurotransmission and behavior ; Nucleus accumbens ; Prepulse inhibition ; Psychology. Psychoanalysis. Psychiatry ; Psychology. 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We reported that, compared to Long–Evans (LEH) rats, Sprague–Dawley (SDH) rats are more sensitive to the PPI-disruptive effects of the direct D1/D2 agonist apomorphine (APO) and the indirect DA agonist d-amphetamine (AMPH). This strain difference is heritable, with PPI drug sensitivity following a generational pattern (SDH>N2>F1>LEH) suggestive of additive effects of multiple genes. Here, we assessed the neurochemical bases for these heritable strain differences by measuring tissue levels of dopamine, serotonin (5HT) and their respective metabolites in several forebrain regions after vehicle, APO or AMPH administration. SDH rats were more sensitive than LEH rats to the PPI-disruptive effects of both APO (0.5 mg/kg) and AMPH (4.5 mg/kg). Several significant SDH vs. LEH strain differences in regional neurochemical levels were detected, as were drug effects on these chemicals. However, SDH, LEH and F1 rats did not exhibit differential drug sensitivity in any neurochemical indices measures. These findings suggest that inherited differences in the dopaminergic regulation of sensorimotor gating do not likely reflect differences in presynaptic forebrain dopaminergic or serotonergic processes.</description><subject>3,4-Dihydroxyphenylacetic Acid - metabolism</subject><subject>Amphetamine</subject><subject>Animals</subject><subject>Apomorphine</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Dopamine</subject><subject>Dopamine - genetics</subject><subject>Dopamine - metabolism</subject><subject>Dopamine Agonists - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Medial prefrontal cortex</subject><subject>Neurotransmission and behavior</subject><subject>Nucleus accumbens</subject><subject>Prepulse inhibition</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Rats, Sprague-Dawley</subject><subject>Reflex, Startle - drug effects</subject><subject>Reflex, Startle - genetics</subject><subject>Reflexes</subject><subject>Schizophrenia</subject><subject>Species Specificity</subject><subject>Startle</subject><subject>Striatum</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EokvhB3BBvsAtwWPHdlacUMWXVMEFzpbjjLdeJU6wnUr993i7K_XGaTQzz7waPYS8BdYCA_Xx2K7D0HLGuhagZYw_IzvotWgkaP2c7BjbQyOY1FfkVc5HVkGu9EtyBVL1DLTYkfgTt7S4O5yDsxO10U4POWS6eJpsobkkGyIdg_eYMDrMtLblDuvGpjIhPdgS4qEZQ07bWsI9UqysK48R47LaOUSk9rDEkEt-TV54O2V8c6nX5M_XL79vvje3v779uPl82zjRQ2kkaiZtL5RjuPcjgPNC9movYdACOJfKaote8IEzdHXc4WidZ0PnHXSdEtfkwzl3TcvfDXMxc8gOp8lGXLZslBZ7xlVXQTiDLi05J_RmTWG26cEAMyfJ5miqZHOSbABMlVxv3l3Ct2HG8eniYrUC7y-AzdWqTza6kJ84JXnXPXKfzhxWFfcBk8kunCyPIVWFZlzCf974B5Opm3I</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Swerdlow, Neal R.</creator><creator>Kuczenski, Ronald</creator><creator>Goins, Jana C.</creator><creator>Crain, Sarah K.</creator><creator>Ma, Lillian T.</creator><creator>Bongiovanni, Michele J.</creator><creator>Shoemaker, Jody M.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>Neurochemical analysis of rat strain differences in the startle gating-disruptive effects of dopamine agonists</title><author>Swerdlow, Neal R. ; Kuczenski, Ronald ; Goins, Jana C. ; Crain, Sarah K. ; Ma, Lillian T. ; Bongiovanni, Michele J. ; Shoemaker, Jody M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-5e705a836c0e9fd11cf3586951b7312256a7aef32b20ec9514edacf0b4fc14463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>3,4-Dihydroxyphenylacetic Acid - metabolism</topic><topic>Amphetamine</topic><topic>Animals</topic><topic>Apomorphine</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Dopamine</topic><topic>Dopamine - genetics</topic><topic>Dopamine - metabolism</topic><topic>Dopamine Agonists - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Medial prefrontal cortex</topic><topic>Neurotransmission and behavior</topic><topic>Nucleus accumbens</topic><topic>Prepulse inhibition</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Rats, Sprague-Dawley</topic><topic>Reflex, Startle - drug effects</topic><topic>Reflex, Startle - genetics</topic><topic>Reflexes</topic><topic>Schizophrenia</topic><topic>Species Specificity</topic><topic>Startle</topic><topic>Striatum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Swerdlow, Neal R.</creatorcontrib><creatorcontrib>Kuczenski, Ronald</creatorcontrib><creatorcontrib>Goins, Jana C.</creatorcontrib><creatorcontrib>Crain, Sarah K.</creatorcontrib><creatorcontrib>Ma, Lillian T.</creatorcontrib><creatorcontrib>Bongiovanni, Michele J.</creatorcontrib><creatorcontrib>Shoemaker, Jody M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Swerdlow, Neal R.</au><au>Kuczenski, Ronald</au><au>Goins, Jana C.</au><au>Crain, Sarah K.</au><au>Ma, Lillian T.</au><au>Bongiovanni, Michele J.</au><au>Shoemaker, Jody M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurochemical analysis of rat strain differences in the startle gating-disruptive effects of dopamine agonists</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>80</volume><issue>2</issue><spage>203</spage><epage>211</epage><pages>203-211</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>The disruption of prepulse inhibition (PPI) in rats by dopamine (DA) agonists is used to study the neural basis of strain differences in dopaminergic function. We reported that, compared to Long–Evans (LEH) rats, Sprague–Dawley (SDH) rats are more sensitive to the PPI-disruptive effects of the direct D1/D2 agonist apomorphine (APO) and the indirect DA agonist d-amphetamine (AMPH). This strain difference is heritable, with PPI drug sensitivity following a generational pattern (SDH>N2>F1>LEH) suggestive of additive effects of multiple genes. Here, we assessed the neurochemical bases for these heritable strain differences by measuring tissue levels of dopamine, serotonin (5HT) and their respective metabolites in several forebrain regions after vehicle, APO or AMPH administration. SDH rats were more sensitive than LEH rats to the PPI-disruptive effects of both APO (0.5 mg/kg) and AMPH (4.5 mg/kg). Several significant SDH vs. LEH strain differences in regional neurochemical levels were detected, as were drug effects on these chemicals. However, SDH, LEH and F1 rats did not exhibit differential drug sensitivity in any neurochemical indices measures. These findings suggest that inherited differences in the dopaminergic regulation of sensorimotor gating do not likely reflect differences in presynaptic forebrain dopaminergic or serotonergic processes.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15680173</pmid><doi>10.1016/j.pbb.2004.11.002</doi><tpages>9</tpages></addata></record> |
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| subjects | 3,4-Dihydroxyphenylacetic Acid - metabolism Amphetamine Animals Apomorphine Behavioral psychophysiology Biological and medical sciences Brain - drug effects Brain - metabolism Dopamine Dopamine - genetics Dopamine - metabolism Dopamine Agonists - pharmacology Female Fundamental and applied biological sciences. Psychology Male Medial prefrontal cortex Neurotransmission and behavior Nucleus accumbens Prepulse inhibition Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Long-Evans Rats, Sprague-Dawley Reflex, Startle - drug effects Reflex, Startle - genetics Reflexes Schizophrenia Species Specificity Startle Striatum |
| title | Neurochemical analysis of rat strain differences in the startle gating-disruptive effects of dopamine agonists |
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