Simvastatin improves endothelial function in patients with rheumatoid arthritis
[...]the aim of the present study was to evaluate the effects of statin therapy on vascular function, plasma lipids, and oxidative stress in patients with RA who have normal cholesterol levels. [...]the reduction of proatherogenic lipids and markers of oxidative stress result in an improvement of va...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2005-02, Vol.45 (3), p.461-464 |
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| container_title | Journal of the American College of Cardiology |
| container_volume | 45 |
| creator | Hermann, Frank Forster, Adrian Chenevard, Rémy Enseleit, Frank Hürlimann, David Corti, Roberto Spieker, Lukas E. Frey, Diana Hermann, Matthias Riesen, Walter Neidhart, Michel Michel, Beat A. Hellermann, Jens P. Gay, Renate E. Lüscher, Thomas F. Gay, Steffen Noll, Georg Ruschitzka, Frank |
| description | [...]the aim of the present study was to evaluate the effects of statin therapy on vascular function, plasma lipids, and oxidative stress in patients with RA who have normal cholesterol levels. [...]the reduction of proatherogenic lipids and markers of oxidative stress result in an improvement of vascular function, indicating that statins may hold the potential as a novel add-on therapy in the treatment of RA. |
| doi_str_mv | 10.1016/j.jacc.2004.11.006 |
| format | Article |
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[...]the reduction of proatherogenic lipids and markers of oxidative stress result in an improvement of vascular function, indicating that statins may hold the potential as a novel add-on therapy in the treatment of RA.</description><subject>Apolipoproteins</subject><subject>Arthritis, Rheumatoid - blood</subject><subject>Arthritis, Rheumatoid - physiopathology</subject><subject>Blood pressure</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Cross-Over Studies</subject><subject>Cytokines</subject><subject>Disease prevention</subject><subject>Double-Blind Method</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</subject><subject>Hypertension</subject><subject>Kinases</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Proteins</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatology</subject><subject>Signal transduction</subject><subject>Simvastatin - pharmacology</subject><subject>Statins</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1L7DAUhoMoOlf9Ay6kILhr7zntJG3AjYheBcGFug5pesqk9GNM0rn4780wA4ILV2fxPu_L4WHsAiFDQPG3yzptTJYDLDPEDEAcsAVyXqUFl-UhW0BZ8BRBlifsj_cdRKJCecxOkIsqhrBgL6922GgfdLBjYoe1mzbkExqbKayot7pP2nk0wU4xHZN1xGgMPvlvwypxK5oHHSbbJNqFlbPB-jN21Ore0_n-nrL3h_u3u8f0-eXf093tc2qWuQip0TXyRiJvpchNvhQyNxXkVAppAChmpeaVKaipywhgLSmXdVssCbhuTF2csuvdbvz4YyYf1GC9ob7XI02zV6IsKsmLIoJXP8Bumt0Yf1PIQSCXIKtI5TvKuMl7R61aOzto96kQ1Fa26tRWttrKVogqqoyly_30XA_UfFf2diNwswMomthYcsqb6M9QYx2ZoJrJ_rb_BYq0kQ0</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Hermann, Frank</creator><creator>Forster, Adrian</creator><creator>Chenevard, Rémy</creator><creator>Enseleit, Frank</creator><creator>Hürlimann, David</creator><creator>Corti, Roberto</creator><creator>Spieker, Lukas E.</creator><creator>Frey, Diana</creator><creator>Hermann, Matthias</creator><creator>Riesen, Walter</creator><creator>Neidhart, Michel</creator><creator>Michel, Beat A.</creator><creator>Hellermann, Jens P.</creator><creator>Gay, Renate E.</creator><creator>Lüscher, Thomas F.</creator><creator>Gay, Steffen</creator><creator>Noll, Georg</creator><creator>Ruschitzka, Frank</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>Simvastatin improves endothelial function in patients with rheumatoid arthritis</title><author>Hermann, Frank ; Forster, Adrian ; Chenevard, Rémy ; Enseleit, Frank ; Hürlimann, David ; Corti, Roberto ; Spieker, Lukas E. ; Frey, Diana ; Hermann, Matthias ; Riesen, Walter ; Neidhart, Michel ; Michel, Beat A. ; Hellermann, Jens P. ; Gay, Renate E. ; Lüscher, Thomas F. ; Gay, Steffen ; Noll, Georg ; Ruschitzka, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-cab15d915f962c24692c802e769c00e15d7a58c3edb762c1b9e29bf34e05adcb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Apolipoproteins</topic><topic>Arthritis, Rheumatoid - blood</topic><topic>Arthritis, Rheumatoid - physiopathology</topic><topic>Blood pressure</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Cross-Over Studies</topic><topic>Cytokines</topic><topic>Disease prevention</topic><topic>Double-Blind Method</topic><topic>Drug dosages</topic><topic>Drug therapy</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</topic><topic>Hypertension</topic><topic>Kinases</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Proteins</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatology</topic><topic>Signal transduction</topic><topic>Simvastatin - pharmacology</topic><topic>Statins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hermann, Frank</creatorcontrib><creatorcontrib>Forster, Adrian</creatorcontrib><creatorcontrib>Chenevard, Rémy</creatorcontrib><creatorcontrib>Enseleit, Frank</creatorcontrib><creatorcontrib>Hürlimann, David</creatorcontrib><creatorcontrib>Corti, Roberto</creatorcontrib><creatorcontrib>Spieker, Lukas E.</creatorcontrib><creatorcontrib>Frey, Diana</creatorcontrib><creatorcontrib>Hermann, Matthias</creatorcontrib><creatorcontrib>Riesen, Walter</creatorcontrib><creatorcontrib>Neidhart, Michel</creatorcontrib><creatorcontrib>Michel, Beat A.</creatorcontrib><creatorcontrib>Hellermann, Jens P.</creatorcontrib><creatorcontrib>Gay, Renate E.</creatorcontrib><creatorcontrib>Lüscher, Thomas F.</creatorcontrib><creatorcontrib>Gay, Steffen</creatorcontrib><creatorcontrib>Noll, Georg</creatorcontrib><creatorcontrib>Ruschitzka, Frank</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hermann, Frank</au><au>Forster, Adrian</au><au>Chenevard, Rémy</au><au>Enseleit, Frank</au><au>Hürlimann, David</au><au>Corti, Roberto</au><au>Spieker, Lukas E.</au><au>Frey, Diana</au><au>Hermann, Matthias</au><au>Riesen, Walter</au><au>Neidhart, Michel</au><au>Michel, Beat A.</au><au>Hellermann, Jens P.</au><au>Gay, Renate E.</au><au>Lüscher, Thomas F.</au><au>Gay, Steffen</au><au>Noll, Georg</au><au>Ruschitzka, Frank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simvastatin improves endothelial function in patients with rheumatoid arthritis</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>45</volume><issue>3</issue><spage>461</spage><epage>464</epage><pages>461-464</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><abstract>[...]the aim of the present study was to evaluate the effects of statin therapy on vascular function, plasma lipids, and oxidative stress in patients with RA who have normal cholesterol levels. 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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Apolipoproteins Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - physiopathology Blood pressure Cardiology Cardiovascular disease Cholesterol Cross-Over Studies Cytokines Disease prevention Double-Blind Method Drug dosages Drug therapy Endothelium, Vascular - drug effects Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hypertension Kinases Lipids Lipids - blood Low density lipoprotein Male Middle Aged Nonsteroidal anti-inflammatory drugs Oxidative stress Oxidative Stress - drug effects Proteins Rheumatoid arthritis Rheumatology Signal transduction Simvastatin - pharmacology Statins |
| title | Simvastatin improves endothelial function in patients with rheumatoid arthritis |
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