Simvastatin improves endothelial function in patients with rheumatoid arthritis

[...]the aim of the present study was to evaluate the effects of statin therapy on vascular function, plasma lipids, and oxidative stress in patients with RA who have normal cholesterol levels. [...]the reduction of proatherogenic lipids and markers of oxidative stress result in an improvement of va...

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Veröffentlicht in:	Journal of the American College of Cardiology 2005-02, Vol.45 (3), p.461-464
Hauptverfasser:	Hermann, Frank, Forster, Adrian, Chenevard, Rémy, Enseleit, Frank, Hürlimann, David, Corti, Roberto, Spieker, Lukas E., Frey, Diana, Hermann, Matthias, Riesen, Walter, Neidhart, Michel, Michel, Beat A., Hellermann, Jens P., Gay, Renate E., Lüscher, Thomas F., Gay, Steffen, Noll, Georg, Ruschitzka, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Apolipoproteins Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - physiopathology Blood pressure Cardiology Cardiovascular disease Cholesterol Cross-Over Studies Cytokines Disease prevention Double-Blind Method Drug dosages Drug therapy Endothelium, Vascular - drug effects Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hypertension Kinases Lipids Lipids - blood Low density lipoprotein Male Middle Aged Nonsteroidal anti-inflammatory drugs Oxidative stress Oxidative Stress - drug effects Proteins Rheumatoid arthritis Rheumatology Signal transduction Simvastatin - pharmacology Statins
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Zusammenfassung:	[...]the aim of the present study was to evaluate the effects of statin therapy on vascular function, plasma lipids, and oxidative stress in patients with RA who have normal cholesterol levels. [...]the reduction of proatherogenic lipids and markers of oxidative stress result in an improvement of vascular function, indicating that statins may hold the potential as a novel add-on therapy in the treatment of RA.
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2004.11.006