The level of ADAM12-S in maternal serum is an early first-trimester marker of fetal trisomy 18

Background ADAM12‐S is a pregnancy‐associated insulin‐like growth factor binding protein‐3 (IGFBP‐3) and IGFBP‐5 protease present in human gestational serum. Recently, maternal serum levels of ADAM12‐S were found to be markedly reduced during the first trimester of pregnancies with a Down syndrome (...

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