Passing the baton in class B GPCRs: peptide hormone activation via helix induction?

G-protein-coupled receptors (GPCRs) represent the largest constellation of validated drug targets. Crystal structures of class A GPCRs have facilitated major advances in understanding the principles underlying GPCR activation. By contrast, relatively little is known about class B GPCRs, a family of...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2009-06, Vol.34 (6), p.303-310
Hauptverfasser:	Parthier, Christoph, Reedtz-Runge, Steffen, Rudolph, Rainer, Stubbs, Milton T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Humans Ligands Models, Biological Molecular Sequence Data Peptide Hormones - metabolism Peptides - chemistry Protein Conformation Protein Folding Protein Structure, Secondary Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - physiology Sequence Homology, Amino Acid
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