A Ratchet Mechanism of Transcription Elongation and Its Control

RNA chain elongation is a highly processive and accurate process that is finely regulated by numerous intrinsic and extrinsic signals. Here we describe a general mechanism that governs RNA polymerase (RNAP) movement and response to regulatory inputs such as pauses, terminators, and elongation factor...

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Veröffentlicht in:	Cell 2005-01, Vol.120 (2), p.183-193
Hauptverfasser:	Bar-Nahum, Gil, Epshtein, Vitaly, Ruckenstein, Andrei E., Rafikov, Ruslan, Mustaev, Arkady, Nudler, Evgeny
Format:	Artikel
Sprache:	eng
Schlagworte:	Cross-Linking Reagents - chemistry DNA - genetics DNA Footprinting - methods DNA-Directed RNA Polymerases - genetics Escherichia coli - genetics Models, Theoretical Mutation - genetics Nucleic Acid Conformation Ribonucleotides - genetics Transcription Factors - genetics Transcription, Genetic
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