Effects of Hepatocyte Growth Factor on the Expression of Type I Collagen and Matrix Metalloproteinase-1 in Normal and Scleroderma Dermal Fibroblasts

We investigated the direct effect of hepatocyte growth factor (HGF) on the expression of type I collagen in normal and scleroderma dermal fibroblasts, and analyzed the mechanisms underlying the effect in vitro. HGF did not change the protein expression of type I procollagen in the medium of normal h...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of investigative dermatology 2005-02, Vol.124 (2), p.324-330
Hauptverfasser:	Jinnin, Masatoshi, Ihn, Hironobu, Mimura, Yoshihiro, Asano, Yoshihide, Yamane, Kenichi, Tamaki, Kunihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cells, Cultured Collagen Type I - genetics Dermatology Dermis - cytology Fibroblasts - cytology Fibroblasts - drug effects Gene Expression - drug effects Hepatocyte Growth Factor - pharmacology Humans In Vitro Techniques Matrix Metalloproteinase 1 - genetics Medical sciences Proto-Oncogene Proteins c-met - genetics RNA, Messenger - analysis Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Scleroderma, Systemic - drug therapy Scleroderma, Systemic - physiopathology tissue inhibitor of metalloproteinases tissue remodeling transforming growth factor-β
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!