Change in filling pattern with preload reduction reflects left ventricular relaxation
Background: The early diastolic mitral valve pressure gradient and the rate of left ventricular filling are determined by the rate of left ventricular relaxation and left atrial pressure at the time of mitral valve opening. Accordingly, we hypothesized that the left ventricular filling pattern with...
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| Veröffentlicht in: | International journal of cardiology 2005-01, Vol.98 (1), p.67-72 |
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| container_title | International journal of cardiology |
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| creator | Tanabe, Masaki Onishi, Katsuya Dohi, Kaoru Funabiki, Kaoru Koji, Takafumi Kitamura, Tetsuya Ito, Masaaki Nobori, Tsutomu Nakano, Takeshi |
| description | Background: The early diastolic mitral valve pressure gradient and the rate of left ventricular filling are determined by the rate of left ventricular relaxation and left atrial pressure at the time of mitral valve opening. Accordingly, we hypothesized that the left ventricular filling pattern with preload reduction can be used to estimate left ventricular relaxation in patients with preserved systolic function.
Methods: We evaluated the relationship between the logistic time constant of left ventricular relaxation and left ventricular filling pattern calculated from the time derivative of left ventricular volume using a microtipmanometer and a conductance catheter in 26 consecutive patients with preserved left ventricular ejection fraction (>45%). Left ventricular filling patterns were determined from the maximal rates of early diastolic left ventricular filling (E velocity) and atrial filling (A velocity) before and after preload reduction by inferior venal caval occlusion.
Results and conclusions: There was no significant relationship between the logistic time constant of left ventricular relaxation and the E/A velocity ratio at baseline. However, the time constant was correlated with the E/A velocity ratio after venal caval occlusion (
r=−0.47,
p=0.02). Furthermore, the time constant was correlated with %E/A velocity change, which was defined as the rate of change of E/A before and after caval occlusion divided by E/A after caval occlusion, more significantly (
r=−0.67,
p |
| doi_str_mv | 10.1016/j.ijcard.2003.11.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67385580</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0167527304000531</els_id><sourcerecordid>67385580</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-d517ed001c172ac0c38ed9519ae33dfdeec02da8f539b3efe673c5e4972dec743</originalsourceid><addsrcrecordid>eNp90EFrHCEUwHEpKc0m7TcoZS7pbSbvjeM4cymEpW0CgVyasxh9k7i4zladJP32ddmF3HJS8PdE_4x9RWgQsL_cNG5jdLRNC8AbxAZAfGArHGRXoxTdCVsVJmvRSn7KzlLaAEA3jsMndoqilz3244rdr590eKTKhWpy3rvwWO10zhRD9eLyU7WL5Gdtq0h2MdnNoewmTyanytOUq2cKOTqzeB3Lideveo8-s4-T9om-HNdzdv_r55_1dX179_tmfXVbGz5Crq1ASRYADcpWGzB8IDsKHDVxbidLZKC1epgEHx84TdRLbgR1o2wtGdnxc_b9cO8uzn8XSlltXTLkvQ40L0kVPwgxQIHdAZo4p1S-oHbRbXX8pxDUPqfaqENOtc-pEFXJWca-He9fHrZk34aO_Qq4OAKdjPZT1MG49Ob6rgeUQ3E_Do5KjWdHUSXjKBiyLpaYys7u_Zf8B575lu8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67385580</pqid></control><display><type>article</type><title>Change in filling pattern with preload reduction reflects left ventricular relaxation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Tanabe, Masaki ; Onishi, Katsuya ; Dohi, Kaoru ; Funabiki, Kaoru ; Koji, Takafumi ; Kitamura, Tetsuya ; Ito, Masaaki ; Nobori, Tsutomu ; Nakano, Takeshi</creator><creatorcontrib>Tanabe, Masaki ; Onishi, Katsuya ; Dohi, Kaoru ; Funabiki, Kaoru ; Koji, Takafumi ; Kitamura, Tetsuya ; Ito, Masaaki ; Nobori, Tsutomu ; Nakano, Takeshi</creatorcontrib><description>Background: The early diastolic mitral valve pressure gradient and the rate of left ventricular filling are determined by the rate of left ventricular relaxation and left atrial pressure at the time of mitral valve opening. Accordingly, we hypothesized that the left ventricular filling pattern with preload reduction can be used to estimate left ventricular relaxation in patients with preserved systolic function.
Methods: We evaluated the relationship between the logistic time constant of left ventricular relaxation and left ventricular filling pattern calculated from the time derivative of left ventricular volume using a microtipmanometer and a conductance catheter in 26 consecutive patients with preserved left ventricular ejection fraction (>45%). Left ventricular filling patterns were determined from the maximal rates of early diastolic left ventricular filling (E velocity) and atrial filling (A velocity) before and after preload reduction by inferior venal caval occlusion.
Results and conclusions: There was no significant relationship between the logistic time constant of left ventricular relaxation and the E/A velocity ratio at baseline. However, the time constant was correlated with the E/A velocity ratio after venal caval occlusion (
r=−0.47,
p=0.02). Furthermore, the time constant was correlated with %E/A velocity change, which was defined as the rate of change of E/A before and after caval occlusion divided by E/A after caval occlusion, more significantly (
r=−0.67,
p<0.01) than with the E/A velocity ratio after caval occlusion. Thus, the left ventricular filling pattern with preload reduction can be used to estimate left ventricular relaxation in patients with preserved left ventricular ejection fraction.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2003.11.005</identifier><identifier>PMID: 15676169</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aged ; Biological and medical sciences ; Blood Flow Velocity ; Cardiology. Vascular system ; Female ; Heart Ventricles - physiopathology ; Humans ; Hypertrophy, Left Ventricular - physiopathology ; Japan ; Left ventricular filling ; Left ventricular relaxation ; Male ; Medical sciences ; Middle Aged ; Myocardial Contraction ; Preload reduction ; Stroke Volume ; Vasodilation ; Ventricular Function, Left ; Ventricular Pressure ; Ventricular Remodeling</subject><ispartof>International journal of cardiology, 2005-01, Vol.98 (1), p.67-72</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-d517ed001c172ac0c38ed9519ae33dfdeec02da8f539b3efe673c5e4972dec743</citedby><cites>FETCH-LOGICAL-c390t-d517ed001c172ac0c38ed9519ae33dfdeec02da8f539b3efe673c5e4972dec743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167527304000531$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16460178$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15676169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanabe, Masaki</creatorcontrib><creatorcontrib>Onishi, Katsuya</creatorcontrib><creatorcontrib>Dohi, Kaoru</creatorcontrib><creatorcontrib>Funabiki, Kaoru</creatorcontrib><creatorcontrib>Koji, Takafumi</creatorcontrib><creatorcontrib>Kitamura, Tetsuya</creatorcontrib><creatorcontrib>Ito, Masaaki</creatorcontrib><creatorcontrib>Nobori, Tsutomu</creatorcontrib><creatorcontrib>Nakano, Takeshi</creatorcontrib><title>Change in filling pattern with preload reduction reflects left ventricular relaxation</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Background: The early diastolic mitral valve pressure gradient and the rate of left ventricular filling are determined by the rate of left ventricular relaxation and left atrial pressure at the time of mitral valve opening. Accordingly, we hypothesized that the left ventricular filling pattern with preload reduction can be used to estimate left ventricular relaxation in patients with preserved systolic function.
Methods: We evaluated the relationship between the logistic time constant of left ventricular relaxation and left ventricular filling pattern calculated from the time derivative of left ventricular volume using a microtipmanometer and a conductance catheter in 26 consecutive patients with preserved left ventricular ejection fraction (>45%). Left ventricular filling patterns were determined from the maximal rates of early diastolic left ventricular filling (E velocity) and atrial filling (A velocity) before and after preload reduction by inferior venal caval occlusion.
Results and conclusions: There was no significant relationship between the logistic time constant of left ventricular relaxation and the E/A velocity ratio at baseline. However, the time constant was correlated with the E/A velocity ratio after venal caval occlusion (
r=−0.47,
p=0.02). Furthermore, the time constant was correlated with %E/A velocity change, which was defined as the rate of change of E/A before and after caval occlusion divided by E/A after caval occlusion, more significantly (
r=−0.67,
p<0.01) than with the E/A velocity ratio after caval occlusion. Thus, the left ventricular filling pattern with preload reduction can be used to estimate left ventricular relaxation in patients with preserved left ventricular ejection fraction.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Cardiology. Vascular system</subject><subject>Female</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Japan</subject><subject>Left ventricular filling</subject><subject>Left ventricular relaxation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Contraction</subject><subject>Preload reduction</subject><subject>Stroke Volume</subject><subject>Vasodilation</subject><subject>Ventricular Function, Left</subject><subject>Ventricular Pressure</subject><subject>Ventricular Remodeling</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90EFrHCEUwHEpKc0m7TcoZS7pbSbvjeM4cymEpW0CgVyasxh9k7i4zladJP32ddmF3HJS8PdE_4x9RWgQsL_cNG5jdLRNC8AbxAZAfGArHGRXoxTdCVsVJmvRSn7KzlLaAEA3jsMndoqilz3244rdr590eKTKhWpy3rvwWO10zhRD9eLyU7WL5Gdtq0h2MdnNoewmTyanytOUq2cKOTqzeB3Lideveo8-s4-T9om-HNdzdv_r55_1dX179_tmfXVbGz5Crq1ASRYADcpWGzB8IDsKHDVxbidLZKC1epgEHx84TdRLbgR1o2wtGdnxc_b9cO8uzn8XSlltXTLkvQ40L0kVPwgxQIHdAZo4p1S-oHbRbXX8pxDUPqfaqENOtc-pEFXJWca-He9fHrZk34aO_Qq4OAKdjPZT1MG49Ob6rgeUQ3E_Do5KjWdHUSXjKBiyLpaYys7u_Zf8B575lu8</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Tanabe, Masaki</creator><creator>Onishi, Katsuya</creator><creator>Dohi, Kaoru</creator><creator>Funabiki, Kaoru</creator><creator>Koji, Takafumi</creator><creator>Kitamura, Tetsuya</creator><creator>Ito, Masaaki</creator><creator>Nobori, Tsutomu</creator><creator>Nakano, Takeshi</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050101</creationdate><title>Change in filling pattern with preload reduction reflects left ventricular relaxation</title><author>Tanabe, Masaki ; Onishi, Katsuya ; Dohi, Kaoru ; Funabiki, Kaoru ; Koji, Takafumi ; Kitamura, Tetsuya ; Ito, Masaaki ; Nobori, Tsutomu ; Nakano, Takeshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-d517ed001c172ac0c38ed9519ae33dfdeec02da8f539b3efe673c5e4972dec743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Cardiology. Vascular system</topic><topic>Female</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>Japan</topic><topic>Left ventricular filling</topic><topic>Left ventricular relaxation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Contraction</topic><topic>Preload reduction</topic><topic>Stroke Volume</topic><topic>Vasodilation</topic><topic>Ventricular Function, Left</topic><topic>Ventricular Pressure</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanabe, Masaki</creatorcontrib><creatorcontrib>Onishi, Katsuya</creatorcontrib><creatorcontrib>Dohi, Kaoru</creatorcontrib><creatorcontrib>Funabiki, Kaoru</creatorcontrib><creatorcontrib>Koji, Takafumi</creatorcontrib><creatorcontrib>Kitamura, Tetsuya</creatorcontrib><creatorcontrib>Ito, Masaaki</creatorcontrib><creatorcontrib>Nobori, Tsutomu</creatorcontrib><creatorcontrib>Nakano, Takeshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanabe, Masaki</au><au>Onishi, Katsuya</au><au>Dohi, Kaoru</au><au>Funabiki, Kaoru</au><au>Koji, Takafumi</au><au>Kitamura, Tetsuya</au><au>Ito, Masaaki</au><au>Nobori, Tsutomu</au><au>Nakano, Takeshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Change in filling pattern with preload reduction reflects left ventricular relaxation</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>98</volume><issue>1</issue><spage>67</spage><epage>72</epage><pages>67-72</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract>Background: The early diastolic mitral valve pressure gradient and the rate of left ventricular filling are determined by the rate of left ventricular relaxation and left atrial pressure at the time of mitral valve opening. Accordingly, we hypothesized that the left ventricular filling pattern with preload reduction can be used to estimate left ventricular relaxation in patients with preserved systolic function.
Methods: We evaluated the relationship between the logistic time constant of left ventricular relaxation and left ventricular filling pattern calculated from the time derivative of left ventricular volume using a microtipmanometer and a conductance catheter in 26 consecutive patients with preserved left ventricular ejection fraction (>45%). Left ventricular filling patterns were determined from the maximal rates of early diastolic left ventricular filling (E velocity) and atrial filling (A velocity) before and after preload reduction by inferior venal caval occlusion.
Results and conclusions: There was no significant relationship between the logistic time constant of left ventricular relaxation and the E/A velocity ratio at baseline. However, the time constant was correlated with the E/A velocity ratio after venal caval occlusion (
r=−0.47,
p=0.02). Furthermore, the time constant was correlated with %E/A velocity change, which was defined as the rate of change of E/A before and after caval occlusion divided by E/A after caval occlusion, more significantly (
r=−0.67,
p<0.01) than with the E/A velocity ratio after caval occlusion. Thus, the left ventricular filling pattern with preload reduction can be used to estimate left ventricular relaxation in patients with preserved left ventricular ejection fraction.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15676169</pmid><doi>10.1016/j.ijcard.2003.11.005</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Blood Flow Velocity Cardiology. Vascular system Female Heart Ventricles - physiopathology Humans Hypertrophy, Left Ventricular - physiopathology Japan Left ventricular filling Left ventricular relaxation Male Medical sciences Middle Aged Myocardial Contraction Preload reduction Stroke Volume Vasodilation Ventricular Function, Left Ventricular Pressure Ventricular Remodeling |
| title | Change in filling pattern with preload reduction reflects left ventricular relaxation |
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