Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders

A recurring translocation (X;20)(q13;q13) was found in four women ranging in age from 57 to 77 years. They had myelodysplasia, myelodysplasia with thrombocytopenia and pancytopenia, transforming to myelofibrosis, and myelodysplasia with sideroblastic anemia, respectively. The t(X;20) was the sole ab...

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Veröffentlicht in:Cancer genetics and cytogenetics 2005-02, Vol.157 (1), p.70-73
Hauptverfasser: Reddy, Kavita S., Richkind, Kathy, Ross, Micheal, Seirra, Rubin
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container_title Cancer genetics and cytogenetics
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creator Reddy, Kavita S.
Richkind, Kathy
Ross, Micheal
Seirra, Rubin
description A recurring translocation (X;20)(q13;q13) was found in four women ranging in age from 57 to 77 years. They had myelodysplasia, myelodysplasia with thrombocytopenia and pancytopenia, transforming to myelofibrosis, and myelodysplasia with sideroblastic anemia, respectively. The t(X;20) was the sole abnormality in three cases; one case also had a der(1;7)(q10;p10). Added to three previously reported cases, our four cases bring the total to seven; thus, t(X;20)(q13;q13) is a nonrandom translocation associated with myeloid disorders. Previous FISH studies showed that the breakpoint on the X is proximal to XIST. In one of our cases, the breakpoint on the X was shown to be proximal to Xq12, by FISH using a probe for the androgen receptor gene locus.
doi_str_mv 10.1016/j.cancergencyto.2004.05.014
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subjects Aged
Chromosomes, Human, Pair 20
Chromosomes, Human, X
Female
Humans
Middle Aged
Myelodysplastic Syndromes - genetics
Pancytopenia - genetics
Primary Myelofibrosis - genetics
Translocation, Genetic
title Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders
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