A single cocaine exposure increases BDNF and D3 receptor expression: implications for drug-conditioning
Environmental stimuli associated with a single cocaine exposure acquire long-lasting motivational properties that are able to induce relapse. We measured Brain-derived neurotrophic factor (BDNF) and dopamine D3 receptor (Drd3) expressions in rat brain regions that have been involved in drug-conditio...
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| Veröffentlicht in: | Neuroreport 2005-02, Vol.16 (2), p.175-178 |
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| creator | Le Foll, Bernard Diaz, Jorge Sokoloff, Pierre |
| description | Environmental stimuli associated with a single cocaine exposure acquire long-lasting motivational properties that are able to induce relapse. We measured Brain-derived neurotrophic factor (BDNF) and dopamine D3 receptor (Drd3) expressions in rat brain regions that have been involved in drug-conditioning. Acute cocaine produced a transient increase in BDNF mRNA in the prefrontal cortex, associated with a long-lasting increase in drd3 mRNA, and a delayed and long-lasting increase in Drd3 protein in the nucleus accumbens. Methamphetamine and morphine, two drugs known to easily induce drug-conditioning, also markedly elevated BDNF mRNA. Nicotine had more limited effects. Abused drugs increase acutely BDNF expression, which leads to subsequent long-lasting elevation of Drd3 in the nucleus accumbens that may facilitate responding to drug-associated stimuli. |
| doi_str_mv | 10.1097/00001756-200502080-00022 |
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| subjects | Animals Biological and medical sciences Brain - drug effects Brain - metabolism Brain-Derived Neurotrophic Factor - biosynthesis Brain-Derived Neurotrophic Factor - genetics Cocaine - administration & dosage Conditioning (Psychology) - drug effects Conditioning (Psychology) - physiology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Receptors, Dopamine D2 - biosynthesis Receptors, Dopamine D2 - genetics Receptors, Dopamine D3 |
| title | A single cocaine exposure increases BDNF and D3 receptor expression: implications for drug-conditioning |
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