Expression of Bone Morphogenetic Proteins in Giant Cell Tumor of Bone
Background: A giant cell tumor (GCT) of bone is a locally aggressive tumor with a propensity for local recurrence. A characteristic pattern of peripheral bone formation has been described in GCT recurrence in soft tissue, and in some pulmonary metastases from benign GCT. Although the bone formation...
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| Veröffentlicht in: | Anticancer research 2009-06, Vol.29 (6), p.2219-2225 |
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| creator | KUDO, Naoko OGOSE, Akira HOTTA, Yuko HOSHINO, Makiko ENDO, Naoto ARIIZUMI, Takashi KAWASHIMA, Hiroyuki HOTTA, Tetsuo HATANO, Hiroshi MORITA, Tetsuro NAGATA, Masaki SIKI, Yukie KAWAI, Akira |
| description | Background: A giant cell tumor (GCT) of bone is a locally aggressive tumor with a propensity for local recurrence. A characteristic
pattern of peripheral bone formation has been described in GCT recurrence in soft tissue, and in some pulmonary metastases
from benign GCT. Although the bone formation in GCT in supposedly due to bone morphogenetic proteins (BMPs), the expression
pattern of BMPs in GCT has not been well investigated. Materials and Methods: The expression of BMPs in GCT tissues, cultured
stromal cells from GCT, and osteoclast-like giant cells harvested by laser microdissection (LM), as well as from control osteosarcoma
(NOS-1) cells was analyzed using reverse transcriptional-semiquantitative PCR. Results: BMP 2, 3, 4, 5 and 6 were expressed
in the GCT tissue. The cultured GCT cells expressed BMP 2, 4, 5 and 6. The osteoclast-like giant cells expressed BMP 2, 3,
5 and 6 and BMP 5 was expressed at the highest level. Conclusion: Both stromal cells and osteoclast-like cells in GCT expressed
several kinds of BMPs. |
| format | Article |
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pattern of peripheral bone formation has been described in GCT recurrence in soft tissue, and in some pulmonary metastases
from benign GCT. Although the bone formation in GCT in supposedly due to bone morphogenetic proteins (BMPs), the expression
pattern of BMPs in GCT has not been well investigated. Materials and Methods: The expression of BMPs in GCT tissues, cultured
stromal cells from GCT, and osteoclast-like giant cells harvested by laser microdissection (LM), as well as from control osteosarcoma
(NOS-1) cells was analyzed using reverse transcriptional-semiquantitative PCR. Results: BMP 2, 3, 4, 5 and 6 were expressed
in the GCT tissue. The cultured GCT cells expressed BMP 2, 4, 5 and 6. The osteoclast-like giant cells expressed BMP 2, 3,
5 and 6 and BMP 5 was expressed at the highest level. Conclusion: Both stromal cells and osteoclast-like cells in GCT expressed
several kinds of BMPs.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 19528484</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Adult ; Biological and medical sciences ; Bone Morphogenetic Proteins - genetics ; Bone Morphogenetic Proteins - metabolism ; Bone Neoplasms - genetics ; Bone Neoplasms - metabolism ; Bone Neoplasms - pathology ; Diseases of the osteoarticular system ; Female ; Giant Cell Tumor of Bone - genetics ; Giant Cell Tumor of Bone - metabolism ; Giant Cell Tumor of Bone - pathology ; Humans ; Lasers ; Male ; Medical sciences ; Microdissection ; Middle Aged ; Osteosarcoma - genetics ; Osteosarcoma - metabolism ; Osteosarcoma - pathology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Stromal Cells - metabolism ; Stromal Cells - pathology ; Tumor Cells, Cultured ; Tumors ; Tumors of striated muscle and skeleton ; Young Adult</subject><ispartof>Anticancer research, 2009-06, Vol.29 (6), p.2219-2225</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21649029$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19528484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUDO, Naoko</creatorcontrib><creatorcontrib>OGOSE, Akira</creatorcontrib><creatorcontrib>HOTTA, Yuko</creatorcontrib><creatorcontrib>HOSHINO, Makiko</creatorcontrib><creatorcontrib>ENDO, Naoto</creatorcontrib><creatorcontrib>ARIIZUMI, Takashi</creatorcontrib><creatorcontrib>KAWASHIMA, Hiroyuki</creatorcontrib><creatorcontrib>HOTTA, Tetsuo</creatorcontrib><creatorcontrib>HATANO, Hiroshi</creatorcontrib><creatorcontrib>MORITA, Tetsuro</creatorcontrib><creatorcontrib>NAGATA, Masaki</creatorcontrib><creatorcontrib>SIKI, Yukie</creatorcontrib><creatorcontrib>KAWAI, Akira</creatorcontrib><title>Expression of Bone Morphogenetic Proteins in Giant Cell Tumor of Bone</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: A giant cell tumor (GCT) of bone is a locally aggressive tumor with a propensity for local recurrence. A characteristic
pattern of peripheral bone formation has been described in GCT recurrence in soft tissue, and in some pulmonary metastases
from benign GCT. Although the bone formation in GCT in supposedly due to bone morphogenetic proteins (BMPs), the expression
pattern of BMPs in GCT has not been well investigated. Materials and Methods: The expression of BMPs in GCT tissues, cultured
stromal cells from GCT, and osteoclast-like giant cells harvested by laser microdissection (LM), as well as from control osteosarcoma
(NOS-1) cells was analyzed using reverse transcriptional-semiquantitative PCR. Results: BMP 2, 3, 4, 5 and 6 were expressed
in the GCT tissue. The cultured GCT cells expressed BMP 2, 4, 5 and 6. The osteoclast-like giant cells expressed BMP 2, 3,
5 and 6 and BMP 5 was expressed at the highest level. Conclusion: Both stromal cells and osteoclast-like cells in GCT expressed
several kinds of BMPs.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Bone Morphogenetic Proteins - genetics</subject><subject>Bone Morphogenetic Proteins - metabolism</subject><subject>Bone Neoplasms - genetics</subject><subject>Bone Neoplasms - metabolism</subject><subject>Bone Neoplasms - pathology</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Giant Cell Tumor of Bone - genetics</subject><subject>Giant Cell Tumor of Bone - metabolism</subject><subject>Giant Cell Tumor of Bone - pathology</subject><subject>Humans</subject><subject>Lasers</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microdissection</subject><subject>Middle Aged</subject><subject>Osteosarcoma - genetics</subject><subject>Osteosarcoma - metabolism</subject><subject>Osteosarcoma - pathology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Stromal Cells - metabolism</subject><subject>Stromal Cells - pathology</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><subject>Tumors of striated muscle and skeleton</subject><subject>Young Adult</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0D1PwzAQBmALgWgp_AWUBbZIZzv-GqEqBakIhjJbbuI0Rokd7ETAvycSBUamG-659053hOZYKJwLRuEYzYEwyAUAm6GzlF4BOFeSnqIZVozIQhZztFp99NGm5ILPQp3dBm-zxxD7Juytt4Mrs-cYBut8ypzP1s74IVvats22Yxfiz8g5OqlNm-zFoS7Qy91qu7zPN0_rh-XNJm8owJCTabvcEcOJtFgUQoIpWSVNAdwwA4TiSnBFmSynLha03DFVMQFUCUtqxukCXX_n9jG8jTYNunOpnM4x3oYxaS6opIrCv5AAlkCnXQt0eYDjrrOV7qPrTPzUPx-awNUBmFSato7Gly79OoJ5oYCoP9e4ffPuotWpM207xVJtIlGaa0Kwol8atnm7</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>KUDO, Naoko</creator><creator>OGOSE, Akira</creator><creator>HOTTA, Yuko</creator><creator>HOSHINO, Makiko</creator><creator>ENDO, Naoto</creator><creator>ARIIZUMI, Takashi</creator><creator>KAWASHIMA, Hiroyuki</creator><creator>HOTTA, Tetsuo</creator><creator>HATANO, Hiroshi</creator><creator>MORITA, Tetsuro</creator><creator>NAGATA, Masaki</creator><creator>SIKI, Yukie</creator><creator>KAWAI, Akira</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20090601</creationdate><title>Expression of Bone Morphogenetic Proteins in Giant Cell Tumor of Bone</title><author>KUDO, Naoko ; OGOSE, Akira ; HOTTA, Yuko ; HOSHINO, Makiko ; ENDO, Naoto ; ARIIZUMI, Takashi ; KAWASHIMA, Hiroyuki ; HOTTA, Tetsuo ; HATANO, Hiroshi ; MORITA, Tetsuro ; NAGATA, Masaki ; SIKI, Yukie ; KAWAI, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h300t-29838b2a628e174780ac5d8a406a5a0231d769358c174173cb59d570397e2f563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Bone Morphogenetic Proteins - genetics</topic><topic>Bone Morphogenetic Proteins - metabolism</topic><topic>Bone Neoplasms - genetics</topic><topic>Bone Neoplasms - metabolism</topic><topic>Bone Neoplasms - pathology</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Giant Cell Tumor of Bone - genetics</topic><topic>Giant Cell Tumor of Bone - metabolism</topic><topic>Giant Cell Tumor of Bone - pathology</topic><topic>Humans</topic><topic>Lasers</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microdissection</topic><topic>Middle Aged</topic><topic>Osteosarcoma - genetics</topic><topic>Osteosarcoma - metabolism</topic><topic>Osteosarcoma - pathology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Stromal Cells - metabolism</topic><topic>Stromal Cells - pathology</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors</topic><topic>Tumors of striated muscle and skeleton</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KUDO, Naoko</creatorcontrib><creatorcontrib>OGOSE, Akira</creatorcontrib><creatorcontrib>HOTTA, Yuko</creatorcontrib><creatorcontrib>HOSHINO, Makiko</creatorcontrib><creatorcontrib>ENDO, Naoto</creatorcontrib><creatorcontrib>ARIIZUMI, Takashi</creatorcontrib><creatorcontrib>KAWASHIMA, Hiroyuki</creatorcontrib><creatorcontrib>HOTTA, Tetsuo</creatorcontrib><creatorcontrib>HATANO, Hiroshi</creatorcontrib><creatorcontrib>MORITA, Tetsuro</creatorcontrib><creatorcontrib>NAGATA, Masaki</creatorcontrib><creatorcontrib>SIKI, Yukie</creatorcontrib><creatorcontrib>KAWAI, Akira</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUDO, Naoko</au><au>OGOSE, Akira</au><au>HOTTA, Yuko</au><au>HOSHINO, Makiko</au><au>ENDO, Naoto</au><au>ARIIZUMI, Takashi</au><au>KAWASHIMA, Hiroyuki</au><au>HOTTA, Tetsuo</au><au>HATANO, Hiroshi</au><au>MORITA, Tetsuro</au><au>NAGATA, Masaki</au><au>SIKI, Yukie</au><au>KAWAI, Akira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Bone Morphogenetic Proteins in Giant Cell Tumor of Bone</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>29</volume><issue>6</issue><spage>2219</spage><epage>2225</epage><pages>2219-2225</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: A giant cell tumor (GCT) of bone is a locally aggressive tumor with a propensity for local recurrence. A characteristic
pattern of peripheral bone formation has been described in GCT recurrence in soft tissue, and in some pulmonary metastases
from benign GCT. Although the bone formation in GCT in supposedly due to bone morphogenetic proteins (BMPs), the expression
pattern of BMPs in GCT has not been well investigated. Materials and Methods: The expression of BMPs in GCT tissues, cultured
stromal cells from GCT, and osteoclast-like giant cells harvested by laser microdissection (LM), as well as from control osteosarcoma
(NOS-1) cells was analyzed using reverse transcriptional-semiquantitative PCR. Results: BMP 2, 3, 4, 5 and 6 were expressed
in the GCT tissue. The cultured GCT cells expressed BMP 2, 4, 5 and 6. The osteoclast-like giant cells expressed BMP 2, 3,
5 and 6 and BMP 5 was expressed at the highest level. Conclusion: Both stromal cells and osteoclast-like cells in GCT expressed
several kinds of BMPs.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>19528484</pmid><tpages>7</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Diseases of the osteoarticular system Female Giant Cell Tumor of Bone - genetics Giant Cell Tumor of Bone - metabolism Giant Cell Tumor of Bone - pathology Humans Lasers Male Medical sciences Microdissection Middle Aged Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Stromal Cells - metabolism Stromal Cells - pathology Tumor Cells, Cultured Tumors Tumors of striated muscle and skeleton Young Adult |
| title | Expression of Bone Morphogenetic Proteins in Giant Cell Tumor of Bone |
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