Transcriptome and proteome analysis identifies the pathways that increase hepatic lipid accumulation in zinc-deficient rats

For identification of the underlying molecular changes in hepatic lipid metabolism in zinc deficiency, rats were force-fed a zinc-deficient diet. Subsequently DNA-microarray and proteome profiling was performed in combination with hepatic lipid analysis. Of 6200 target sequences analyzed, 268 transc...

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Veröffentlicht in:	The Journal of nutrition 2005-02, Vol.135 (2), p.199-205
Hauptverfasser:	Dieck, H. tom, Doring, F, Fuchs, D, Roth, H.P, Daniel, H
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Biological and medical sciences dietary minerals enzymatic reactions fatty acids Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology gene expression Gene Expression Regulation Lipid Metabolism Liver - metabolism liver function Male messenger RNA metabolic sequestration nutrient deficiencies Oligonucleotide Array Sequence Analysis proteins Proteome Rats Reference Values Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Transcription, Genetic transcriptome transporters Vertebrates: anatomy and physiology, studies on body, several organs or systems zinc Zinc - deficiency
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