Dissecting the Molecular Control of Endothelial NO Synthase by Caveolin-1 Using Cell-Permeable Peptides

In endothelia, NO is synthesized by endothelial NO synthase (eNOS), which is negatively regulated by caveolin-1 (Cav-1), the primary coat protein of caveolae. We show that delivery of Cav-1 amino acids 82-101 (Cav) fused to an internalization sequence from Antennapedia (AP) blocks NO release in vitr...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-01, Vol.102 (3), p.761-766
Hauptverfasser:	Bernatchez, Pascal N., Bauer, Philip M., Yu, Jun, Prendergast, Jay S., He, Pingnian, Sessa, William C., Ignarro, Louis J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Anti-Inflammatory Agents - chemical synthesis Antineoplastic Agents - chemical synthesis Biological Sciences Cattle Caveolin 1 Caveolins - physiology Cell Membrane Permeability Cells Cells, Cultured Complementary DNA COS cells Dose-Response Relationship, Drug Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium, Vascular - cytology Enzymes Hydraulic conductivity Inflammation Kinetics Medical research Molecules Mustards Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase Type III Nitrites Peptide Fragments - chemical synthesis Peptide Fragments - pharmacology Peptides Permeability Pretreatment Recombinant Fusion Proteins Venules
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