Quantitative assessment of the hepatic pharmacokinetics of the antimicrobial sitafloxacin in humans using in vivoF magnetic resonance spectroscopy
To measure hepatic concentrations of the fluorine-containing antimicrobial, sitafloxacin, using in vivo(19)F magnetic resonance spectroscopy (MRS). Data were acquired from eight healthy subjects at 2, 5, 8 and 24 h following doses of 500 mg day(-1) for 5 days using a (1)H/(19)F surface coil in a 1.5...
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| Veröffentlicht in: | British journal of clinical pharmacology 2005-02, Vol.59 (2), p.244-248 |
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| container_title | British journal of clinical pharmacology |
| container_volume | 59 |
| creator | Payne, Geoffrey S Collins, David J Loynds, Peter Mould, Graham Murphy, Philip S Dzik-Jurasz, Andrzej S K Kessar, Preminda Haque, Nazneen Yamaguchi, Masayuki Atarashi, Shogo Leach, Martin O |
| description | To measure hepatic concentrations of the fluorine-containing antimicrobial, sitafloxacin, using in vivo(19)F magnetic resonance spectroscopy (MRS).
Data were acquired from eight healthy subjects at 2, 5, 8 and 24 h following doses of 500 mg day(-1) for 5 days using a (1)H/(19)F surface coil in a 1.5T clinical MR system. Tissue water was used as a reference.
Estimated liver concentrations at 2 h were 15.0 +/- 4.0 microg ml(-1) (mean +/- 95% CI), compared with 3.54 +/- 0.58 microg ml(-1) in plasma (n = 6), and fell below threshold concentrations (2 microg ml(-1)) by 24 h.
(19)F MRS is able to detect and quantify sitafloxacin in the liver. There was no evidence for the hepatic retention of the drug. |
| format | Article |
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Data were acquired from eight healthy subjects at 2, 5, 8 and 24 h following doses of 500 mg day(-1) for 5 days using a (1)H/(19)F surface coil in a 1.5T clinical MR system. Tissue water was used as a reference.
Estimated liver concentrations at 2 h were 15.0 +/- 4.0 microg ml(-1) (mean +/- 95% CI), compared with 3.54 +/- 0.58 microg ml(-1) in plasma (n = 6), and fell below threshold concentrations (2 microg ml(-1)) by 24 h.
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Data were acquired from eight healthy subjects at 2, 5, 8 and 24 h following doses of 500 mg day(-1) for 5 days using a (1)H/(19)F surface coil in a 1.5T clinical MR system. Tissue water was used as a reference.
Estimated liver concentrations at 2 h were 15.0 +/- 4.0 microg ml(-1) (mean +/- 95% CI), compared with 3.54 +/- 0.58 microg ml(-1) in plasma (n = 6), and fell below threshold concentrations (2 microg ml(-1)) by 24 h.
(19)F MRS is able to detect and quantify sitafloxacin in the liver. There was no evidence for the hepatic retention of the drug.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-Infective Agents - pharmacokinetics</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Fluorine Radioisotopes</subject><subject>Fluoroquinolones - pharmacokinetics</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Liver - metabolism</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><issn>0306-5251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1Kw0AUhbNQbK2-gszKXWAm85NkKcWqUBCh-3AzuWlGk5mYmxT7Gj6xqVo4cDmcc77FvYiWXHIT60SLRXRN9M65kMLoq2ghtEkNV_ky-n6bwI9uhNEdkAEREnXoRxZqNjbIGuznyLK-gaEDGz6cx9nTOT-NO2eHUDpoGc2gug1fYJ1ns5qpA09sIuf3J39wh7BhHex_IWxACh68RUY92nEIZEN_vIkua2gJb__vKtptHnfr53j7-vSyftjGvVZ5bDSUIJXMsiRFxWUN0tZCWGk0VlnO81Qlmc4VN1alFa_LrExKbUzNQUnBK7mK7v-w_RA-J6Sx6BxZbFvwGCYqTCozmQg9F-_-i1PZYVX0g-tgOBbnJ8ofhwJwrA</recordid><startdate>200502</startdate><enddate>200502</enddate><creator>Payne, Geoffrey S</creator><creator>Collins, David J</creator><creator>Loynds, Peter</creator><creator>Mould, Graham</creator><creator>Murphy, Philip S</creator><creator>Dzik-Jurasz, Andrzej S K</creator><creator>Kessar, Preminda</creator><creator>Haque, Nazneen</creator><creator>Yamaguchi, Masayuki</creator><creator>Atarashi, Shogo</creator><creator>Leach, Martin O</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200502</creationdate><title>Quantitative assessment of the hepatic pharmacokinetics of the antimicrobial sitafloxacin in humans using in vivoF magnetic resonance spectroscopy</title><author>Payne, Geoffrey S ; Collins, David J ; Loynds, Peter ; Mould, Graham ; Murphy, Philip S ; Dzik-Jurasz, Andrzej S K ; Kessar, Preminda ; Haque, Nazneen ; Yamaguchi, Masayuki ; Atarashi, Shogo ; Leach, Martin O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p549-65aba3438827e403fa3cf11c365ed8909742859406c47d0fb8b2b566f0a4310d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-Infective Agents - pharmacokinetics</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Fluorine Radioisotopes</topic><topic>Fluoroquinolones - pharmacokinetics</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Liver - metabolism</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Payne, Geoffrey S</creatorcontrib><creatorcontrib>Collins, David J</creatorcontrib><creatorcontrib>Loynds, Peter</creatorcontrib><creatorcontrib>Mould, Graham</creatorcontrib><creatorcontrib>Murphy, Philip S</creatorcontrib><creatorcontrib>Dzik-Jurasz, Andrzej S K</creatorcontrib><creatorcontrib>Kessar, Preminda</creatorcontrib><creatorcontrib>Haque, Nazneen</creatorcontrib><creatorcontrib>Yamaguchi, Masayuki</creatorcontrib><creatorcontrib>Atarashi, Shogo</creatorcontrib><creatorcontrib>Leach, Martin O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Payne, Geoffrey S</au><au>Collins, David J</au><au>Loynds, Peter</au><au>Mould, Graham</au><au>Murphy, Philip S</au><au>Dzik-Jurasz, Andrzej S K</au><au>Kessar, Preminda</au><au>Haque, Nazneen</au><au>Yamaguchi, Masayuki</au><au>Atarashi, Shogo</au><au>Leach, Martin O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative assessment of the hepatic pharmacokinetics of the antimicrobial sitafloxacin in humans using in vivoF magnetic resonance spectroscopy</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>2005-02</date><risdate>2005</risdate><volume>59</volume><issue>2</issue><spage>244</spage><epage>248</epage><pages>244-248</pages><issn>0306-5251</issn><abstract>To measure hepatic concentrations of the fluorine-containing antimicrobial, sitafloxacin, using in vivo(19)F magnetic resonance spectroscopy (MRS).
Data were acquired from eight healthy subjects at 2, 5, 8 and 24 h following doses of 500 mg day(-1) for 5 days using a (1)H/(19)F surface coil in a 1.5T clinical MR system. Tissue water was used as a reference.
Estimated liver concentrations at 2 h were 15.0 +/- 4.0 microg ml(-1) (mean +/- 95% CI), compared with 3.54 +/- 0.58 microg ml(-1) in plasma (n = 6), and fell below threshold concentrations (2 microg ml(-1)) by 24 h.
(19)F MRS is able to detect and quantify sitafloxacin in the liver. There was no evidence for the hepatic retention of the drug.</abstract><cop>England</cop><pmid>15676049</pmid><tpages>5</tpages></addata></record> |
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| ispartof | British journal of clinical pharmacology, 2005-02, Vol.59 (2), p.244-248 |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Anti-Infective Agents - pharmacokinetics Chromatography, High Pressure Liquid Fluorine Radioisotopes Fluoroquinolones - pharmacokinetics Half-Life Humans Liver - metabolism Magnetic Resonance Spectroscopy - methods Male |
| title | Quantitative assessment of the hepatic pharmacokinetics of the antimicrobial sitafloxacin in humans using in vivoF magnetic resonance spectroscopy |
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