The role of radiotracer imaging in Parkinson disease

Radiotracer imaging (RTI) of the nigrostriatal dopaminergic system is a widely used but controversial biomarker in Parkinson disease (PD). Here the authors review the concepts of biomarker development and the evidence to support the use of four radiotracers as biomarkers in PD: [18F]fluorodopa PET,...

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Veröffentlicht in:	Neurology 2005-01, Vol.64 (2), p.208-215
Hauptverfasser:	RAVINA, B, EIDELBERG, D, GWINN-HARDY, K, MCFARLAND, H, INNIS, R, KATZ, R. G, KIEBURTZ, K, KISH, S. J, LANGE, N, LANGSTON, J. W, MAREK, K, MORIN, L, AHLSKOG, J. E, MOY, C, MURPHY, D, OERTEL, W. H, OLIVER, G, PALESCH, Y, POWERS, W, SEIBYL, J, SETHI, K. D, SHULTS, C. W, SHEEHY, P, ALBIN, R. L, STOESSL, A. J, HOLLOWAY, R, BROOKS, D. J, CARBON, M, DHAWAN, V, FEIGIN, A, FAHN, S, GUTTMAN, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers Biotransformation Blood-Brain Barrier Carbon Radioisotopes - pharmacokinetics Clinical Trials as Topic - methods Cocaine - analogs & derivatives Cocaine - pharmacokinetics Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dihydroxyphenylalanine - analogs & derivatives Dihydroxyphenylalanine - pharmacokinetics Dopamine - metabolism Fluorine Radioisotopes - pharmacokinetics Fluorodeoxyglucose F18 - pharmacokinetics Forecasting Humans Investigative techniques, diagnostic techniques (general aspects) Iodine Radioisotopes - pharmacokinetics Medical sciences Nervous system Neurology Neurons - chemistry Neurons - diagnostic imaging Parkinson Disease - diagnosis Parkinson Disease - diagnostic imaging Parkinson Disease - therapy Positron-Emission Tomography Prognosis Radiodiagnosis. Nmr imagery. Nmr spectrometry Radiopharmaceuticals - pharmacokinetics Receptors, Dopamine - metabolism Substantia Nigra - diagnostic imaging Substantia Nigra - metabolism Tetrabenazine - analogs & derivatives Tetrabenazine - pharmacokinetics Tomography, Emission-Computed, Single-Photon
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