Changes in serum levels of heat shock protein 70 in preterm delivery and pre-eclampsia
Aim: The aim of this study was to investigate heat‐shock protein (Hsp)70 as a novel marker to evaluate the curative effects of treatment for preterm delivery high‐risk patients and pre‐eclampsia. Methods: After obtaining informed consent, serum samples were collected from 31 preterm delivery high‐ri...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2005-02, Vol.31 (1), p.72-77 |
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| container_title | The journal of obstetrics and gynaecology research |
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| creator | Fukushima, Akimune Kawahara, Hisao Isurugi, Chizuko Syoji, Tadahiro Oyama, Rie Sugiyama, Toru Horiuchi, Saburo |
| description | Aim: The aim of this study was to investigate heat‐shock protein (Hsp)70 as a novel marker to evaluate the curative effects of treatment for preterm delivery high‐risk patients and pre‐eclampsia.
Methods: After obtaining informed consent, serum samples were collected from 31 preterm delivery high‐risk patients with a tocolysis index of three points or above (A), seven pre‐eclampsia patients (P), 46 normal pregnant women (B), and seven non‐pregnant women (C). Of the 31 preterm delivery high‐risk patients, 15 had preterm delivery (Ap) and 16 had full‐term delivery (Af ). The levels of Hsp70 were measured using enzyme‐linked immunosorbent assay.
Results: The Hsp70 levels in normal pregnant women were 8.6 ± 1.9 ng/mL (first trimester), 5.5 ± 1.0 ng/mL (second trimester) and 5.5 ± 0.7 ng/mL (third trimester). There was no statistical difference in the Hsp70 levels between the three trimesters. The mean Hsp70 levels were 21.9 ± 5.3 ng/mL (A), 35.3 ± 9.6 ng/mL (Ap), 9.4 ± 2.2 ng/mL (Af), 24.4 ± 3.6 ng/mL (P), 6.1 ± 0.6 ng/mL (B), and 2.4 ± 0.6 ng/mL (C). Group Ap had significantly higher Hsp70 levels than group Af (P = 0.0112) and group B (P |
| doi_str_mv | 10.1111/j.1447-0756.2005.00244.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67381899</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67381899</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5234-5805a0bb804b5196291c41781758bb84aef04131b849c3b5d945ab13a396cd9b3</originalsourceid><addsrcrecordid>eNqNkEFPwyAUx4nROJ1-BcPJWysUKJB40UWnZnGXqUdC2zfXrV0ndLp9e6lb9CoXXh6__-PlhxCmJKbhXM1jyrmMiBRpnBAiYkISzuPNATr5fTgMNeM0UkSmPXTq_ZwQKjVVx6hHRZpqreUJeh3M7PIdPC6X2INb17iCT6g8bqZ4BrbFftbkC7xyTQsBkaQDVw5acDUuoCo_wW2xXRZdM4K8svXKl_YMHU1t5eF8f_fRy_3dZPAQjcbDx8HNKMpFwngkFBGWZJkiPBNUp4mmOadSUSlU6HILU8Ipo6HUOctEobmwGWWW6TQvdMb66HI3Nyz4sQbfmrr0OVSVXUKz9iaVTFGldQDVDsxd472DqVm5srZuaygxnVMzN50606kznVPz49RsQvRi_8c6q6H4C-4lBuB6B3yVFWz_Pdg8jYehCPFoFy99C5vfuHWLbn0pzNvz0Nwmik8memBG7BsYuJLP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67381899</pqid></control><display><type>article</type><title>Changes in serum levels of heat shock protein 70 in preterm delivery and pre-eclampsia</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Fukushima, Akimune ; Kawahara, Hisao ; Isurugi, Chizuko ; Syoji, Tadahiro ; Oyama, Rie ; Sugiyama, Toru ; Horiuchi, Saburo</creator><creatorcontrib>Fukushima, Akimune ; Kawahara, Hisao ; Isurugi, Chizuko ; Syoji, Tadahiro ; Oyama, Rie ; Sugiyama, Toru ; Horiuchi, Saburo</creatorcontrib><description>Aim: The aim of this study was to investigate heat‐shock protein (Hsp)70 as a novel marker to evaluate the curative effects of treatment for preterm delivery high‐risk patients and pre‐eclampsia.
Methods: After obtaining informed consent, serum samples were collected from 31 preterm delivery high‐risk patients with a tocolysis index of three points or above (A), seven pre‐eclampsia patients (P), 46 normal pregnant women (B), and seven non‐pregnant women (C). Of the 31 preterm delivery high‐risk patients, 15 had preterm delivery (Ap) and 16 had full‐term delivery (Af ). The levels of Hsp70 were measured using enzyme‐linked immunosorbent assay.
Results: The Hsp70 levels in normal pregnant women were 8.6 ± 1.9 ng/mL (first trimester), 5.5 ± 1.0 ng/mL (second trimester) and 5.5 ± 0.7 ng/mL (third trimester). There was no statistical difference in the Hsp70 levels between the three trimesters. The mean Hsp70 levels were 21.9 ± 5.3 ng/mL (A), 35.3 ± 9.6 ng/mL (Ap), 9.4 ± 2.2 ng/mL (Af), 24.4 ± 3.6 ng/mL (P), 6.1 ± 0.6 ng/mL (B), and 2.4 ± 0.6 ng/mL (C). Group Ap had significantly higher Hsp70 levels than group Af (P = 0.0112) and group B (P < 0.0001). The duration of pregnancy after hospitalization for group Ap was significantly shorter than that for group Af (P = 0.0088) and group B (P < 0.0001). Group P also had significantly higher Hsp70 levels than group B (P < 0.0001).
Conclusion: Because Hsp70 levels were particularly high in treatment‐resistant preterm delivery cases, Hsp70 may prove to be a useful marker for evaluating the curative effects of treatment for preterm delivery.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/j.1447-0756.2005.00244.x</identifier><identifier>PMID: 15669997</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>Adult ; Biomarkers - blood ; Case-Control Studies ; Female ; Gestational Age ; heat shock protein 70 ; HSP70 Heat-Shock Proteins - blood ; Humans ; Obstetric Labor, Premature - blood ; Parity ; pre-eclampsia ; Pre-Eclampsia - blood ; Predictive Value of Tests ; Pregnancy ; Pregnancy Trimesters - blood ; preterm delivery</subject><ispartof>The journal of obstetrics and gynaecology research, 2005-02, Vol.31 (1), p.72-77</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5234-5805a0bb804b5196291c41781758bb84aef04131b849c3b5d945ab13a396cd9b3</citedby><cites>FETCH-LOGICAL-c5234-5805a0bb804b5196291c41781758bb84aef04131b849c3b5d945ab13a396cd9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1447-0756.2005.00244.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1447-0756.2005.00244.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15669997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukushima, Akimune</creatorcontrib><creatorcontrib>Kawahara, Hisao</creatorcontrib><creatorcontrib>Isurugi, Chizuko</creatorcontrib><creatorcontrib>Syoji, Tadahiro</creatorcontrib><creatorcontrib>Oyama, Rie</creatorcontrib><creatorcontrib>Sugiyama, Toru</creatorcontrib><creatorcontrib>Horiuchi, Saburo</creatorcontrib><title>Changes in serum levels of heat shock protein 70 in preterm delivery and pre-eclampsia</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Aim: The aim of this study was to investigate heat‐shock protein (Hsp)70 as a novel marker to evaluate the curative effects of treatment for preterm delivery high‐risk patients and pre‐eclampsia.
Methods: After obtaining informed consent, serum samples were collected from 31 preterm delivery high‐risk patients with a tocolysis index of three points or above (A), seven pre‐eclampsia patients (P), 46 normal pregnant women (B), and seven non‐pregnant women (C). Of the 31 preterm delivery high‐risk patients, 15 had preterm delivery (Ap) and 16 had full‐term delivery (Af ). The levels of Hsp70 were measured using enzyme‐linked immunosorbent assay.
Results: The Hsp70 levels in normal pregnant women were 8.6 ± 1.9 ng/mL (first trimester), 5.5 ± 1.0 ng/mL (second trimester) and 5.5 ± 0.7 ng/mL (third trimester). There was no statistical difference in the Hsp70 levels between the three trimesters. The mean Hsp70 levels were 21.9 ± 5.3 ng/mL (A), 35.3 ± 9.6 ng/mL (Ap), 9.4 ± 2.2 ng/mL (Af), 24.4 ± 3.6 ng/mL (P), 6.1 ± 0.6 ng/mL (B), and 2.4 ± 0.6 ng/mL (C). Group Ap had significantly higher Hsp70 levels than group Af (P = 0.0112) and group B (P < 0.0001). The duration of pregnancy after hospitalization for group Ap was significantly shorter than that for group Af (P = 0.0088) and group B (P < 0.0001). Group P also had significantly higher Hsp70 levels than group B (P < 0.0001).
Conclusion: Because Hsp70 levels were particularly high in treatment‐resistant preterm delivery cases, Hsp70 may prove to be a useful marker for evaluating the curative effects of treatment for preterm delivery.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Gestational Age</subject><subject>heat shock protein 70</subject><subject>HSP70 Heat-Shock Proteins - blood</subject><subject>Humans</subject><subject>Obstetric Labor, Premature - blood</subject><subject>Parity</subject><subject>pre-eclampsia</subject><subject>Pre-Eclampsia - blood</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Pregnancy Trimesters - blood</subject><subject>preterm delivery</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFPwyAUx4nROJ1-BcPJWysUKJB40UWnZnGXqUdC2zfXrV0ndLp9e6lb9CoXXh6__-PlhxCmJKbhXM1jyrmMiBRpnBAiYkISzuPNATr5fTgMNeM0UkSmPXTq_ZwQKjVVx6hHRZpqreUJeh3M7PIdPC6X2INb17iCT6g8bqZ4BrbFftbkC7xyTQsBkaQDVw5acDUuoCo_wW2xXRZdM4K8svXKl_YMHU1t5eF8f_fRy_3dZPAQjcbDx8HNKMpFwngkFBGWZJkiPBNUp4mmOadSUSlU6HILU8Ipo6HUOctEobmwGWWW6TQvdMb66HI3Nyz4sQbfmrr0OVSVXUKz9iaVTFGldQDVDsxd472DqVm5srZuaygxnVMzN50606kznVPz49RsQvRi_8c6q6H4C-4lBuB6B3yVFWz_Pdg8jYehCPFoFy99C5vfuHWLbn0pzNvz0Nwmik8memBG7BsYuJLP</recordid><startdate>200502</startdate><enddate>200502</enddate><creator>Fukushima, Akimune</creator><creator>Kawahara, Hisao</creator><creator>Isurugi, Chizuko</creator><creator>Syoji, Tadahiro</creator><creator>Oyama, Rie</creator><creator>Sugiyama, Toru</creator><creator>Horiuchi, Saburo</creator><general>Blackwell Science Pty</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200502</creationdate><title>Changes in serum levels of heat shock protein 70 in preterm delivery and pre-eclampsia</title><author>Fukushima, Akimune ; Kawahara, Hisao ; Isurugi, Chizuko ; Syoji, Tadahiro ; Oyama, Rie ; Sugiyama, Toru ; Horiuchi, Saburo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5234-5805a0bb804b5196291c41781758bb84aef04131b849c3b5d945ab13a396cd9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Gestational Age</topic><topic>heat shock protein 70</topic><topic>HSP70 Heat-Shock Proteins - blood</topic><topic>Humans</topic><topic>Obstetric Labor, Premature - blood</topic><topic>Parity</topic><topic>pre-eclampsia</topic><topic>Pre-Eclampsia - blood</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Pregnancy Trimesters - blood</topic><topic>preterm delivery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukushima, Akimune</creatorcontrib><creatorcontrib>Kawahara, Hisao</creatorcontrib><creatorcontrib>Isurugi, Chizuko</creatorcontrib><creatorcontrib>Syoji, Tadahiro</creatorcontrib><creatorcontrib>Oyama, Rie</creatorcontrib><creatorcontrib>Sugiyama, Toru</creatorcontrib><creatorcontrib>Horiuchi, Saburo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukushima, Akimune</au><au>Kawahara, Hisao</au><au>Isurugi, Chizuko</au><au>Syoji, Tadahiro</au><au>Oyama, Rie</au><au>Sugiyama, Toru</au><au>Horiuchi, Saburo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in serum levels of heat shock protein 70 in preterm delivery and pre-eclampsia</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2005-02</date><risdate>2005</risdate><volume>31</volume><issue>1</issue><spage>72</spage><epage>77</epage><pages>72-77</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim: The aim of this study was to investigate heat‐shock protein (Hsp)70 as a novel marker to evaluate the curative effects of treatment for preterm delivery high‐risk patients and pre‐eclampsia.
Methods: After obtaining informed consent, serum samples were collected from 31 preterm delivery high‐risk patients with a tocolysis index of three points or above (A), seven pre‐eclampsia patients (P), 46 normal pregnant women (B), and seven non‐pregnant women (C). Of the 31 preterm delivery high‐risk patients, 15 had preterm delivery (Ap) and 16 had full‐term delivery (Af ). The levels of Hsp70 were measured using enzyme‐linked immunosorbent assay.
Results: The Hsp70 levels in normal pregnant women were 8.6 ± 1.9 ng/mL (first trimester), 5.5 ± 1.0 ng/mL (second trimester) and 5.5 ± 0.7 ng/mL (third trimester). There was no statistical difference in the Hsp70 levels between the three trimesters. The mean Hsp70 levels were 21.9 ± 5.3 ng/mL (A), 35.3 ± 9.6 ng/mL (Ap), 9.4 ± 2.2 ng/mL (Af), 24.4 ± 3.6 ng/mL (P), 6.1 ± 0.6 ng/mL (B), and 2.4 ± 0.6 ng/mL (C). Group Ap had significantly higher Hsp70 levels than group Af (P = 0.0112) and group B (P < 0.0001). The duration of pregnancy after hospitalization for group Ap was significantly shorter than that for group Af (P = 0.0088) and group B (P < 0.0001). Group P also had significantly higher Hsp70 levels than group B (P < 0.0001).
Conclusion: Because Hsp70 levels were particularly high in treatment‐resistant preterm delivery cases, Hsp70 may prove to be a useful marker for evaluating the curative effects of treatment for preterm delivery.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>15669997</pmid><doi>10.1111/j.1447-0756.2005.00244.x</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Biomarkers - blood Case-Control Studies Female Gestational Age heat shock protein 70 HSP70 Heat-Shock Proteins - blood Humans Obstetric Labor, Premature - blood Parity pre-eclampsia Pre-Eclampsia - blood Predictive Value of Tests Pregnancy Pregnancy Trimesters - blood preterm delivery |
| title | Changes in serum levels of heat shock protein 70 in preterm delivery and pre-eclampsia |
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