SNPs and haplotypes in the S100B gene reveal association with schizophrenia
The S100B gene locates in 21q22.3 and produces neurotrophin mainly in astrocytes of CNS which can act as an extensive marker of glial cell integrity. The synaptic destabilization hypothesis (GGF/SD) suggests that the functional deficiency of growth factors like S100B is involved in the etiology of s...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2005-03, Vol.328 (1), p.335-341 |
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| creator | Liu, Jixia Shi, Yongyong Tang, Junxia Guo, Tingwei Li, Xiuxia Yang, Yifeng Chen, Qingying Zhao, Xinzhi He, Guang Feng, Guoyin Gu, Niufan Zhu, Shaomin Liu, Huijun He, Lin |
| description | The S100B gene locates in 21q22.3 and produces neurotrophin mainly in astrocytes of CNS which can act as an extensive marker of glial cell integrity. The synaptic destabilization hypothesis (GGF/SD) suggests that the functional deficiency of growth factors like S100B is involved in the etiology of schizophrenia and the S100B serum concentration is reported to be significantly increased in patients with acute schizophrenia and decreased in chronic schizophrenia patients. To validate the association between S100B and schizophrenia, 384 cases and 401 controls, all Chinese Han subjects, were recruited. Four SNPs V1 (−960C
>
G), V2 (−111C
>
T), V3 (2757C
>
G, rs1051169), and V4 (5748C
>
T, rs9722) were studied. And haplotype V3–V4 (G–C) showed a significant association with schizophrenia. Our study showed an association between schizophrenia and a possible susceptible haplotype V3–V4 (G–C) which possesses a genetic tendency for increased S100B expression. Our results suggest that S100B could be a susceptible gene for schizophrenia and provide indirect evidence for the GGF/SD hypothesis. |
| doi_str_mv | 10.1016/j.bbrc.2004.12.175 |
| format | Article |
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>
G), V2 (−111C
>
T), V3 (2757C
>
G, rs1051169), and V4 (5748C
>
T, rs9722) were studied. And haplotype V3–V4 (G–C) showed a significant association with schizophrenia. Our study showed an association between schizophrenia and a possible susceptible haplotype V3–V4 (G–C) which possesses a genetic tendency for increased S100B expression. Our results suggest that S100B could be a susceptible gene for schizophrenia and provide indirect evidence for the GGF/SD hypothesis.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2004.12.175</identifier><identifier>PMID: 15670788</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Association ; Biomarkers, Tumor - genetics ; China - epidemiology ; DNA Mutational Analysis - methods ; Female ; Genetic Predisposition to Disease - epidemiology ; Genetic Testing - methods ; Growth factors’ deficiency and synaptic destabilization hypothesis of schizophrenia ; Haplotype ; Haplotypes - genetics ; Humans ; Linkage disequilibrium ; Male ; Nerve Growth Factors ; Polymorphism, Single Nucleotide - genetics ; Risk Assessment - methods ; Risk Factors ; S100 Calcium Binding Protein beta Subunit ; S100 Proteins ; S100B ; Schizophrenia - enzymology ; Schizophrenia - epidemiology ; Schizophrenia - genetics ; Sp1</subject><ispartof>Biochemical and biophysical research communications, 2005-03, Vol.328 (1), p.335-341</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-8351728fe0639c4cb3572168135838b617a5a69066abda1354e0c1563678090f3</citedby><cites>FETCH-LOGICAL-c385t-8351728fe0639c4cb3572168135838b617a5a69066abda1354e0c1563678090f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X04029377$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15670788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Jixia</creatorcontrib><creatorcontrib>Shi, Yongyong</creatorcontrib><creatorcontrib>Tang, Junxia</creatorcontrib><creatorcontrib>Guo, Tingwei</creatorcontrib><creatorcontrib>Li, Xiuxia</creatorcontrib><creatorcontrib>Yang, Yifeng</creatorcontrib><creatorcontrib>Chen, Qingying</creatorcontrib><creatorcontrib>Zhao, Xinzhi</creatorcontrib><creatorcontrib>He, Guang</creatorcontrib><creatorcontrib>Feng, Guoyin</creatorcontrib><creatorcontrib>Gu, Niufan</creatorcontrib><creatorcontrib>Zhu, Shaomin</creatorcontrib><creatorcontrib>Liu, Huijun</creatorcontrib><creatorcontrib>He, Lin</creatorcontrib><title>SNPs and haplotypes in the S100B gene reveal association with schizophrenia</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The S100B gene locates in 21q22.3 and produces neurotrophin mainly in astrocytes of CNS which can act as an extensive marker of glial cell integrity. The synaptic destabilization hypothesis (GGF/SD) suggests that the functional deficiency of growth factors like S100B is involved in the etiology of schizophrenia and the S100B serum concentration is reported to be significantly increased in patients with acute schizophrenia and decreased in chronic schizophrenia patients. To validate the association between S100B and schizophrenia, 384 cases and 401 controls, all Chinese Han subjects, were recruited. Four SNPs V1 (−960C
>
G), V2 (−111C
>
T), V3 (2757C
>
G, rs1051169), and V4 (5748C
>
T, rs9722) were studied. And haplotype V3–V4 (G–C) showed a significant association with schizophrenia. Our study showed an association between schizophrenia and a possible susceptible haplotype V3–V4 (G–C) which possesses a genetic tendency for increased S100B expression. Our results suggest that S100B could be a susceptible gene for schizophrenia and provide indirect evidence for the GGF/SD hypothesis.</description><subject>Adult</subject><subject>Association</subject><subject>Biomarkers, Tumor - genetics</subject><subject>China - epidemiology</subject><subject>DNA Mutational Analysis - methods</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genetic Testing - methods</subject><subject>Growth factors’ deficiency and synaptic destabilization hypothesis of schizophrenia</subject><subject>Haplotype</subject><subject>Haplotypes - genetics</subject><subject>Humans</subject><subject>Linkage disequilibrium</subject><subject>Male</subject><subject>Nerve Growth Factors</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>S100 Calcium Binding Protein beta Subunit</subject><subject>S100 Proteins</subject><subject>S100B</subject><subject>Schizophrenia - enzymology</subject><subject>Schizophrenia - epidemiology</subject><subject>Schizophrenia - genetics</subject><subject>Sp1</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFq3DAQhkVISbZpXyCHoFNudmcsW5Ihl2RJ2tLQFtJCb0KWZ2MtXtuRvCnp01fLLuTWngaG7_-Z-Rg7R8gRUH5Y500TXF4AlDkWOarqiC0QasgKhPKYLQBAZkWNv07Z2xjXAIilrE_YKVZSgdJ6wb48fP0euR1a3tmpH-eXiSL3A5874g8IcMMfaSAe6Jlsz22Mo_N29uPAf_u549F1_s84dYEGb9-xNyvbR3p_mGfs593tj-Wn7P7bx8_L6_vMCV3NmRYVqkKvCKSoXekaUakCpUZRaaEbicpWVtYgpW1am7YlgUsXC6l0em4lztjlvncK49OW4mw2PjrqezvQuI1GKqHT69V_QVRlOqbEBBZ70IUxxkArMwW_seHFIJida7M2O9dm59pgkZK79otD-7bZUPsaOchNwNUeoCTj2VMw0XkaHLU-kJtNO_p_9f8Fy0WNJw</recordid><startdate>20050304</startdate><enddate>20050304</enddate><creator>Liu, Jixia</creator><creator>Shi, Yongyong</creator><creator>Tang, Junxia</creator><creator>Guo, Tingwei</creator><creator>Li, Xiuxia</creator><creator>Yang, Yifeng</creator><creator>Chen, Qingying</creator><creator>Zhao, Xinzhi</creator><creator>He, Guang</creator><creator>Feng, Guoyin</creator><creator>Gu, Niufan</creator><creator>Zhu, Shaomin</creator><creator>Liu, Huijun</creator><creator>He, Lin</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050304</creationdate><title>SNPs and haplotypes in the S100B gene reveal association with schizophrenia</title><author>Liu, Jixia ; Shi, Yongyong ; Tang, Junxia ; Guo, Tingwei ; Li, Xiuxia ; Yang, Yifeng ; Chen, Qingying ; Zhao, Xinzhi ; He, Guang ; Feng, Guoyin ; Gu, Niufan ; Zhu, Shaomin ; Liu, Huijun ; He, Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-8351728fe0639c4cb3572168135838b617a5a69066abda1354e0c1563678090f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Association</topic><topic>Biomarkers, Tumor - genetics</topic><topic>China - epidemiology</topic><topic>DNA Mutational Analysis - methods</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>Genetic Testing - methods</topic><topic>Growth factors’ deficiency and synaptic destabilization hypothesis of schizophrenia</topic><topic>Haplotype</topic><topic>Haplotypes - genetics</topic><topic>Humans</topic><topic>Linkage disequilibrium</topic><topic>Male</topic><topic>Nerve Growth Factors</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Risk Assessment - methods</topic><topic>Risk Factors</topic><topic>S100 Calcium Binding Protein beta Subunit</topic><topic>S100 Proteins</topic><topic>S100B</topic><topic>Schizophrenia - enzymology</topic><topic>Schizophrenia - epidemiology</topic><topic>Schizophrenia - genetics</topic><topic>Sp1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Jixia</creatorcontrib><creatorcontrib>Shi, Yongyong</creatorcontrib><creatorcontrib>Tang, Junxia</creatorcontrib><creatorcontrib>Guo, Tingwei</creatorcontrib><creatorcontrib>Li, Xiuxia</creatorcontrib><creatorcontrib>Yang, Yifeng</creatorcontrib><creatorcontrib>Chen, Qingying</creatorcontrib><creatorcontrib>Zhao, Xinzhi</creatorcontrib><creatorcontrib>He, Guang</creatorcontrib><creatorcontrib>Feng, Guoyin</creatorcontrib><creatorcontrib>Gu, Niufan</creatorcontrib><creatorcontrib>Zhu, Shaomin</creatorcontrib><creatorcontrib>Liu, Huijun</creatorcontrib><creatorcontrib>He, Lin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Jixia</au><au>Shi, Yongyong</au><au>Tang, Junxia</au><au>Guo, Tingwei</au><au>Li, Xiuxia</au><au>Yang, Yifeng</au><au>Chen, Qingying</au><au>Zhao, Xinzhi</au><au>He, Guang</au><au>Feng, Guoyin</au><au>Gu, Niufan</au><au>Zhu, Shaomin</au><au>Liu, Huijun</au><au>He, Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SNPs and haplotypes in the S100B gene reveal association with schizophrenia</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2005-03-04</date><risdate>2005</risdate><volume>328</volume><issue>1</issue><spage>335</spage><epage>341</epage><pages>335-341</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The S100B gene locates in 21q22.3 and produces neurotrophin mainly in astrocytes of CNS which can act as an extensive marker of glial cell integrity. The synaptic destabilization hypothesis (GGF/SD) suggests that the functional deficiency of growth factors like S100B is involved in the etiology of schizophrenia and the S100B serum concentration is reported to be significantly increased in patients with acute schizophrenia and decreased in chronic schizophrenia patients. To validate the association between S100B and schizophrenia, 384 cases and 401 controls, all Chinese Han subjects, were recruited. Four SNPs V1 (−960C
>
G), V2 (−111C
>
T), V3 (2757C
>
G, rs1051169), and V4 (5748C
>
T, rs9722) were studied. And haplotype V3–V4 (G–C) showed a significant association with schizophrenia. Our study showed an association between schizophrenia and a possible susceptible haplotype V3–V4 (G–C) which possesses a genetic tendency for increased S100B expression. Our results suggest that S100B could be a susceptible gene for schizophrenia and provide indirect evidence for the GGF/SD hypothesis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15670788</pmid><doi>10.1016/j.bbrc.2004.12.175</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Association Biomarkers, Tumor - genetics China - epidemiology DNA Mutational Analysis - methods Female Genetic Predisposition to Disease - epidemiology Genetic Testing - methods Growth factors’ deficiency and synaptic destabilization hypothesis of schizophrenia Haplotype Haplotypes - genetics Humans Linkage disequilibrium Male Nerve Growth Factors Polymorphism, Single Nucleotide - genetics Risk Assessment - methods Risk Factors S100 Calcium Binding Protein beta Subunit S100 Proteins S100B Schizophrenia - enzymology Schizophrenia - epidemiology Schizophrenia - genetics Sp1 |
| title | SNPs and haplotypes in the S100B gene reveal association with schizophrenia |
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