Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16
Side population (SP) is reported to be a stem cell-rich population. In the presence of leukemia inhibitory factor (LIF), cultured kidney SP cells differentiated into multi-lineage in collagen gel but not in synthesized polymer that has no cell adhesion factor. In cultured kidney SP cells, gene expre...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2005-03, Vol.328 (1), p.288-291 |
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| creator | Hishikawa, Keiichi Marumo, Takeshi Miura, Shigeki Nakanishi, Asato Matsuzaki, Yumi Shibata, Katsunori Kohike, Hiroko Komori, Takuya Hayashi, Matsuhiko Nakaki, Toshio Nakauchi, Hiromitsu Okano, Hideyuki Fujita, Toshiro |
| description | Side population (SP) is reported to be a stem cell-rich population. In the presence of leukemia inhibitory factor (LIF), cultured kidney SP cells differentiated into multi-lineage in collagen gel but not in synthesized polymer that has no cell adhesion factor. In cultured kidney SP cells, gene expression of kidney-specific cadherin 16 was specifically upregulated in collagen gel but not in synthesized polymer. Moreover, decreasing cadherin 16 expression using siRNA abolished LIF-induced multi-lineage differentiation of kidney SP in collagen gel. These results indicated that LIF induced multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16. |
| doi_str_mv | 10.1016/j.bbrc.2004.12.167 |
| format | Article |
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In the presence of leukemia inhibitory factor (LIF), cultured kidney SP cells differentiated into multi-lineage in collagen gel but not in synthesized polymer that has no cell adhesion factor. In cultured kidney SP cells, gene expression of kidney-specific cadherin 16 was specifically upregulated in collagen gel but not in synthesized polymer. Moreover, decreasing cadherin 16 expression using siRNA abolished LIF-induced multi-lineage differentiation of kidney SP in collagen gel. 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In the presence of leukemia inhibitory factor (LIF), cultured kidney SP cells differentiated into multi-lineage in collagen gel but not in synthesized polymer that has no cell adhesion factor. In cultured kidney SP cells, gene expression of kidney-specific cadherin 16 was specifically upregulated in collagen gel but not in synthesized polymer. Moreover, decreasing cadherin 16 expression using siRNA abolished LIF-induced multi-lineage differentiation of kidney SP in collagen gel. These results indicated that LIF induced multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16.</description><subject>Animals</subject><subject>Cadherin 16</subject><subject>Cadherins - metabolism</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Lineage - drug effects</subject><subject>Cell Lineage - physiology</subject><subject>Interleukin-6 - pharmacology</subject><subject>Kidney - cytology</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Leukemia Inhibitory Factor</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Regenerative medicine</subject><subject>Stem cell</subject><subject>Stem Cells - classification</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - drug effects</subject><subject>Stem Cells - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFDEUhYM4OO3oC7iQrNxVmZtKJR1wI8P4Aw1uHJhdSCU3Trrrp02qBno9L26KbnCnZHFD-M7hko-Qd8BqYCA_7uuuS67mjIkaeA1SvSAbYJpVHJh4STaMMVlxDQ_X5HXOe8YAhNSvyDW0UjG15RvyvMPlgEO0NI6PsYvzlE40WFdmefGLw0yHpZ9j1ccR7S-kPoaACcc52jlOI50Ctb4QNM84FOqA1GHf5xKnh-hHPNGnUn--VvmILoboqLP-EVNhQL4hV8H2Gd9e5g25_3L38_Zbtfvx9fvt513lRAtzpTlHUY6TytlO8lZrIayVXHvWqJVBGUCydqtscE1A6ETQ0DmLjRW8a27Ih3PvMU2_F8yzGWJed7UjTks2UjVKy4b9FwS1hVZsVQH5GXRpyjlhMMcUB5tOBphZHZm9WR2Z1ZEBboqjEnp_aV-6Af3fyEVKAT6dASyf8RQxmewijg59TOhm46f4r_4_pVilBA</recordid><startdate>20050304</startdate><enddate>20050304</enddate><creator>Hishikawa, Keiichi</creator><creator>Marumo, Takeshi</creator><creator>Miura, Shigeki</creator><creator>Nakanishi, Asato</creator><creator>Matsuzaki, Yumi</creator><creator>Shibata, Katsunori</creator><creator>Kohike, Hiroko</creator><creator>Komori, Takuya</creator><creator>Hayashi, Matsuhiko</creator><creator>Nakaki, Toshio</creator><creator>Nakauchi, Hiromitsu</creator><creator>Okano, Hideyuki</creator><creator>Fujita, Toshiro</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050304</creationdate><title>Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16</title><author>Hishikawa, Keiichi ; 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| subjects | Animals Cadherin 16 Cadherins - metabolism Cell Differentiation - drug effects Cell Differentiation - physiology Cell Lineage - drug effects Cell Lineage - physiology Interleukin-6 - pharmacology Kidney - cytology Kidney - drug effects Kidney - metabolism Leukemia Inhibitory Factor Mice Mice, Inbred C57BL Regenerative medicine Stem cell Stem Cells - classification Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism |
| title | Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16 |
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