The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake

Neutrophil-gelatinase-associated lipocalin (NGAL) is a prominent protein of specific granules of human neutrophils also synthesized by epithelial cells during inflammation. NGAL binds bacterial siderophores preventing bacteria from retrieving iron from this source. Also, NGAL may be important in del...

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Veröffentlicht in:	FEBS letters 2005-01, Vol.579 (3), p.773-777
Hauptverfasser:	Hvidberg, Vibeke, Jacobsen, Christian, Strong, Roland K., Cowland, Jack B., Moestrup, Søren K., Borregaard, Niels
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins - metabolism Bacteria Brown Norway Endocytosis Humans Iron Iron - metabolism Lcn-1 Lcn-2 LDL-receptor related protein Lipocalin lipocalin-1 Lipocalin-2 Lipocalins Low Density Lipoprotein Receptor-Related Protein-2 - metabolism LRP Megalin neutrophil-gelatinase-associated lipocalin NGAL Oncogene Proteins - metabolism Protein Binding Proto-Oncogene Proteins RAP receptor associated protein Recombinant Proteins - metabolism Siderophore SPR Surface Plasmon Resonance
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