Posterior cortical atrophy: variant of Alzheimer's disease? A case series with PET findings
Nine patients with posterior cortical atrophy (PCA), a rare degenerative brain disease of unclear etiology and nosology, were followed over a mean time of 7.4 years. The mean age at onset was low (56.2 years). At onset, eight patients had visuo-spatial and eight had memory impairment. A minority sho...
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| Veröffentlicht in: | Journal of neurology 2005, Vol.252 (1), p.27-35 |
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| description | Nine patients with posterior cortical atrophy (PCA), a rare degenerative brain disease of unclear etiology and nosology, were followed over a mean time of 7.4 years. The mean age at onset was low (56.2 years). At onset, eight patients had visuo-spatial and eight had memory impairment. A minority showed early signs of occipital lobe involvement with visual agnosia or hemianopia. Eight patients developed dementia after a mean course of five years. 18F-FDG-PET data of six patients were analysed with statistical parametric mapping. They showed hypometabolism centred on the lateral and medial parietal associative cortex, with variable involvement of the adjacent temporal and occipital associative cortex. A minority showed involvement of the frontal lobes, possibly related to deafferenting of areas related to the control of eye movements. Atrophy and hypometabolism were markedly asymmetric in a subset of cases. Autopsy was performed in one patient. Presenile onset, location, and asymmetry of atrophy suggest that PCA represents a biologically separable variant of Alzheimer's disease. |
| doi_str_mv | 10.1007/s00415-005-0594-5 |
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A case series with PET findings</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>SCHMIDTKE, Klaus ; HÜLL, Michael ; TALAZKO, Jochen</creator><creatorcontrib>SCHMIDTKE, Klaus ; HÜLL, Michael ; TALAZKO, Jochen</creatorcontrib><description>Nine patients with posterior cortical atrophy (PCA), a rare degenerative brain disease of unclear etiology and nosology, were followed over a mean time of 7.4 years. The mean age at onset was low (56.2 years). At onset, eight patients had visuo-spatial and eight had memory impairment. A minority showed early signs of occipital lobe involvement with visual agnosia or hemianopia. Eight patients developed dementia after a mean course of five years. 18F-FDG-PET data of six patients were analysed with statistical parametric mapping. They showed hypometabolism centred on the lateral and medial parietal associative cortex, with variable involvement of the adjacent temporal and occipital associative cortex. A minority showed involvement of the frontal lobes, possibly related to deafferenting of areas related to the control of eye movements. Atrophy and hypometabolism were markedly asymmetric in a subset of cases. Autopsy was performed in one patient. Presenile onset, location, and asymmetry of atrophy suggest that PCA represents a biologically separable variant of Alzheimer's disease.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-005-0594-5</identifier><identifier>PMID: 15654552</identifier><identifier>CODEN: JNRYA9</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Age of Onset ; Agnosia - diagnostic imaging ; Agnosia - pathology ; Agnosia - physiopathology ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - pathology ; Alzheimer Disease - physiopathology ; Atrophy - diagnostic imaging ; Atrophy - pathology ; Atrophy - physiopathology ; Biological and medical sciences ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - pathology ; Cerebral Cortex - physiopathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Diagnosis, Differential ; Disease Progression ; Energy Metabolism - physiology ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hemianopsia - diagnostic imaging ; Hemianopsia - pathology ; Hemianopsia - physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Memory Disorders - diagnostic imaging ; Memory Disorders - pathology ; Memory Disorders - physiopathology ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Occipital Lobe - diagnostic imaging ; Occipital Lobe - pathology ; Occipital Lobe - physiopathology ; Parietal Lobe - diagnostic imaging ; Parietal Lobe - pathology ; Parietal Lobe - physiopathology ; Positron-Emission Tomography ; Radiography ; Retrospective Studies ; Time Factors</subject><ispartof>Journal of neurology, 2005, Vol.252 (1), p.27-35</ispartof><rights>2005 INIST-CNRS</rights><rights>Steinkopff Verlag 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4021,27921,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16436813$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15654552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHMIDTKE, Klaus</creatorcontrib><creatorcontrib>HÜLL, Michael</creatorcontrib><creatorcontrib>TALAZKO, Jochen</creatorcontrib><title>Posterior cortical atrophy: variant of Alzheimer's disease? A case series with PET findings</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><description>Nine patients with posterior cortical atrophy (PCA), a rare degenerative brain disease of unclear etiology and nosology, were followed over a mean time of 7.4 years. The mean age at onset was low (56.2 years). At onset, eight patients had visuo-spatial and eight had memory impairment. A minority showed early signs of occipital lobe involvement with visual agnosia or hemianopia. Eight patients developed dementia after a mean course of five years. 18F-FDG-PET data of six patients were analysed with statistical parametric mapping. They showed hypometabolism centred on the lateral and medial parietal associative cortex, with variable involvement of the adjacent temporal and occipital associative cortex. A minority showed involvement of the frontal lobes, possibly related to deafferenting of areas related to the control of eye movements. Atrophy and hypometabolism were markedly asymmetric in a subset of cases. Autopsy was performed in one patient. Presenile onset, location, and asymmetry of atrophy suggest that PCA represents a biologically separable variant of Alzheimer's disease.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Agnosia - diagnostic imaging</subject><subject>Agnosia - pathology</subject><subject>Agnosia - physiopathology</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Atrophy - diagnostic imaging</subject><subject>Atrophy - pathology</subject><subject>Atrophy - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - pathology</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Diagnosis, Differential</subject><subject>Disease Progression</subject><subject>Energy Metabolism - physiology</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Hemianopsia - diagnostic imaging</subject><subject>Hemianopsia - pathology</subject><subject>Hemianopsia - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory Disorders - diagnostic imaging</subject><subject>Memory Disorders - pathology</subject><subject>Memory Disorders - physiopathology</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Occipital Lobe - diagnostic imaging</subject><subject>Occipital Lobe - pathology</subject><subject>Occipital Lobe - physiopathology</subject><subject>Parietal Lobe - diagnostic imaging</subject><subject>Parietal Lobe - pathology</subject><subject>Parietal Lobe - physiopathology</subject><subject>Positron-Emission Tomography</subject><subject>Radiography</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkEtLAzEUhYMotlZ_gBsJgroazTtTN1JKfUDBLurKxZDJZGzKzGRMZpT6602xInjhchbnO5fDBeAUo2uMkLwJCDHME4Ti8jFL-B4YYkZJghkf74MhogwlnHI2AEchrBFCaTQOwQBzwRnnZAheFy50xlvnoXa-s1pVUHXetavNLfxQ3qqmg66Ek-prZWxt_FWAhQ1GBXMHJ1BHhSHmTYCftlvBxWwJS9sUtnkLx-CgVFUwJzsdgZf72XL6mMyfH56mk3nSEiG6hAukiwLz7ZRaF5rmsR0TBSWMmpRwopXKeW5ItGRKGMbalDKXY5JTKUo6Apc_d1vv3nsTuqy2QZuqUo1xfciEjDHMZATP_4Fr1_smdssIjsQYyS10toP6vDZF1npbK7_Jfn8WgYsdoEJ8V-lVo2344wSjIsWUfgM5JXpa</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>SCHMIDTKE, Klaus</creator><creator>HÜLL, Michael</creator><creator>TALAZKO, Jochen</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>Posterior cortical atrophy: variant of Alzheimer's disease? A case series with PET findings</title><author>SCHMIDTKE, Klaus ; HÜLL, Michael ; TALAZKO, Jochen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-560cdd155555fccdc3b65446d3243e8252caab5be2dc3782411cef7b792b376f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Agnosia - diagnostic imaging</topic><topic>Agnosia - pathology</topic><topic>Agnosia - physiopathology</topic><topic>Alzheimer Disease - diagnostic imaging</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Atrophy - diagnostic imaging</topic><topic>Atrophy - pathology</topic><topic>Atrophy - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Cerebral Cortex - pathology</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Diagnosis, Differential</topic><topic>Disease Progression</topic><topic>Energy Metabolism - physiology</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Hemianopsia - diagnostic imaging</topic><topic>Hemianopsia - pathology</topic><topic>Hemianopsia - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory Disorders - diagnostic imaging</topic><topic>Memory Disorders - pathology</topic><topic>Memory Disorders - physiopathology</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Occipital Lobe - diagnostic imaging</topic><topic>Occipital Lobe - pathology</topic><topic>Occipital Lobe - physiopathology</topic><topic>Parietal Lobe - diagnostic imaging</topic><topic>Parietal Lobe - pathology</topic><topic>Parietal Lobe - physiopathology</topic><topic>Positron-Emission Tomography</topic><topic>Radiography</topic><topic>Retrospective Studies</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHMIDTKE, Klaus</creatorcontrib><creatorcontrib>HÜLL, Michael</creatorcontrib><creatorcontrib>TALAZKO, Jochen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHMIDTKE, Klaus</au><au>HÜLL, Michael</au><au>TALAZKO, Jochen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Posterior cortical atrophy: variant of Alzheimer's disease? A case series with PET findings</atitle><jtitle>Journal of neurology</jtitle><addtitle>J Neurol</addtitle><date>2005</date><risdate>2005</risdate><volume>252</volume><issue>1</issue><spage>27</spage><epage>35</epage><pages>27-35</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><coden>JNRYA9</coden><abstract>Nine patients with posterior cortical atrophy (PCA), a rare degenerative brain disease of unclear etiology and nosology, were followed over a mean time of 7.4 years. The mean age at onset was low (56.2 years). At onset, eight patients had visuo-spatial and eight had memory impairment. A minority showed early signs of occipital lobe involvement with visual agnosia or hemianopia. Eight patients developed dementia after a mean course of five years. 18F-FDG-PET data of six patients were analysed with statistical parametric mapping. They showed hypometabolism centred on the lateral and medial parietal associative cortex, with variable involvement of the adjacent temporal and occipital associative cortex. A minority showed involvement of the frontal lobes, possibly related to deafferenting of areas related to the control of eye movements. Atrophy and hypometabolism were markedly asymmetric in a subset of cases. Autopsy was performed in one patient. Presenile onset, location, and asymmetry of atrophy suggest that PCA represents a biologically separable variant of Alzheimer's disease.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>15654552</pmid><doi>10.1007/s00415-005-0594-5</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Age of Onset Agnosia - diagnostic imaging Agnosia - pathology Agnosia - physiopathology Alzheimer Disease - diagnostic imaging Alzheimer Disease - pathology Alzheimer Disease - physiopathology Atrophy - diagnostic imaging Atrophy - pathology Atrophy - physiopathology Biological and medical sciences Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Cerebral Cortex - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diagnosis, Differential Disease Progression Energy Metabolism - physiology Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hemianopsia - diagnostic imaging Hemianopsia - pathology Hemianopsia - physiopathology Humans Magnetic Resonance Imaging Male Medical sciences Memory Disorders - diagnostic imaging Memory Disorders - pathology Memory Disorders - physiopathology Middle Aged Nervous system (semeiology, syndromes) Neurology Occipital Lobe - diagnostic imaging Occipital Lobe - pathology Occipital Lobe - physiopathology Parietal Lobe - diagnostic imaging Parietal Lobe - pathology Parietal Lobe - physiopathology Positron-Emission Tomography Radiography Retrospective Studies Time Factors |
| title | Posterior cortical atrophy: variant of Alzheimer's disease? A case series with PET findings |
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