Extended antiretroviral treatment interruption in HIV‐infected patients with long‐term suppression of plasma HIV RNA
Objectives Evaluation of extended treatment interruption (TI) in chronic HIV infection among patients successfully treated with antiretroviral therapy. Methods An observational analysis of 25 patients in a prospectively followed cohort with chronic HIV infection, viral loads
Gespeichert in:
| Veröffentlicht in: | HIV medicine 2005-01, Vol.6 (1), p.7-12 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 12 |
|---|---|
| container_issue | 1 |
| container_start_page | 7 |
| container_title | HIV medicine |
| container_volume | 6 |
| creator | Achenbach, CJ Till, M Palella, FJ Knoll, MD Terp, SM Kalnins, AU Murphy, RL |
| description | Objectives
Evaluation of extended treatment interruption (TI) in chronic HIV infection among patients successfully treated with antiretroviral therapy.
Methods
An observational analysis of 25 patients in a prospectively followed cohort with chronic HIV infection, viral loads |
| doi_str_mv | 10.1111/j.1468-1293.2005.00257.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67377910</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17811351</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4477-254c716be1b340f512c58d5cfb7f463c0ac11d242444099356ccf9012c30f7c23</originalsourceid><addsrcrecordid>eNqNkc1OFTEUxxuDEURfgXTlbsaeft5J2BCCQkI0Meq26e200pv5su3AZecj-Iw8CR3uDS6lm57m_H7nJP0jhIHUUM7HTQ1criqgDaspIaImhApVb1-ho-fGwVPNKyolPURvU9oQAoo15A06BCEVoVweoe3FNruhdS02Qw7R5Tjehmg6nKMzuXdDxmHILsZ5ymEcygNfXv18-PM3DN7ZXLzJ5FCwhO9CvsHdOPwq3WL0OM3TFF1Kizd6PHUm9WbR8bcvZ-_Qa2-65N7v72P049PF9_PL6vrr56vzs-vKcq5URQW3CuTawZpx4gVQK1atsH6tPJfMEmMBWsop55w0DRPSWt-QgjHilaXsGH3YzZ3i-Ht2Kes-JOu6zgxunJOWiinVAPkvCGoFwAQUcLUDbRxTis7rKYbexHsNRC_x6I1eUtBLCnqJRz_Fo7dFPdnvmNe9a_-J-zwKcLoD7kLn7l88WJdPLQV7BE5hoQE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17811351</pqid></control><display><type>article</type><title>Extended antiretroviral treatment interruption in HIV‐infected patients with long‐term suppression of plasma HIV RNA</title><source>Wiley Free Content</source><source>MEDLINE</source><source>IngentaConnect Free/Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Achenbach, CJ ; Till, M ; Palella, FJ ; Knoll, MD ; Terp, SM ; Kalnins, AU ; Murphy, RL</creator><creatorcontrib>Achenbach, CJ ; Till, M ; Palella, FJ ; Knoll, MD ; Terp, SM ; Kalnins, AU ; Murphy, RL</creatorcontrib><description>Objectives
Evaluation of extended treatment interruption (TI) in chronic HIV infection among patients successfully treated with antiretroviral therapy.
Methods
An observational analysis of 25 patients in a prospectively followed cohort with chronic HIV infection, viral loads <500 HIV‐1 RNA copies/mL for at least 6 months, and an interruption in therapy of ≥28 days duration was carried out. Follow up was divided into 3‐month time periods for analysis. The effects of time period, stratification group and stratification group by time period interactions on CD4 counts were tested using a mixed model. Univariate comparisons among patient characteristics and responses were performed using Fisher's exact test or the Wilcoxon rank sum test.
Results
At initiation of TI, the median CD4 count was 799 cells/μL. TI duration was a median of 7.1 months. HIV RNA rebounded to a median maximum level of 75 000 copies/mL. Maximum viral rebound was significantly greater in patients who were male, had lipodystrophy and had zenith HIV RNA prior to TI of ≥50 000 copies/mL. Lower CD4 cell counts were observed during TI in patients with lipodystrophy, zenith HIV RNA ≥50 000 copies/mL, history of AIDS, HIV infection ≥5 years and presuppression CD4 count ≤350 cells/μL. Patients who reinitiated therapy had shorter TI duration, presuppression CD4 count ≤350 cells/μL, previous AIDS diagnosis and lipodystrophy. No patients developed adverse or AIDS‐defining events during TI.
Conclusions
Long‐term TI resulted in greater immune deterioration in patients with high viral set points or low CD4 cell counts prior to initiation of suppressive antiretroviral therapy.</description><identifier>ISSN: 1464-2662</identifier><identifier>EISSN: 1468-1293</identifier><identifier>DOI: 10.1111/j.1468-1293.2005.00257.x</identifier><identifier>PMID: 15670246</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Anti-HIV Agents - administration & dosage ; antiretroviral therapy ; Antiretroviral Therapy, Highly Active - methods ; CD4 Lymphocyte Count ; Chronic Disease ; chronic HIV ; Disease Progression ; Drug Administration Schedule ; Female ; Follow-Up Studies ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV Infections - virology ; HIV-1 - isolation & purification ; Human immunodeficiency virus 1 ; Humans ; Male ; Middle Aged ; RNA, Viral - blood ; treatment interruption ; Viral Load</subject><ispartof>HIV medicine, 2005-01, Vol.6 (1), p.7-12</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4477-254c716be1b340f512c58d5cfb7f463c0ac11d242444099356ccf9012c30f7c23</citedby><cites>FETCH-LOGICAL-c4477-254c716be1b340f512c58d5cfb7f463c0ac11d242444099356ccf9012c30f7c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1468-1293.2005.00257.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1468-1293.2005.00257.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15670246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Achenbach, CJ</creatorcontrib><creatorcontrib>Till, M</creatorcontrib><creatorcontrib>Palella, FJ</creatorcontrib><creatorcontrib>Knoll, MD</creatorcontrib><creatorcontrib>Terp, SM</creatorcontrib><creatorcontrib>Kalnins, AU</creatorcontrib><creatorcontrib>Murphy, RL</creatorcontrib><title>Extended antiretroviral treatment interruption in HIV‐infected patients with long‐term suppression of plasma HIV RNA</title><title>HIV medicine</title><addtitle>HIV Med</addtitle><description>Objectives
Evaluation of extended treatment interruption (TI) in chronic HIV infection among patients successfully treated with antiretroviral therapy.
Methods
An observational analysis of 25 patients in a prospectively followed cohort with chronic HIV infection, viral loads <500 HIV‐1 RNA copies/mL for at least 6 months, and an interruption in therapy of ≥28 days duration was carried out. Follow up was divided into 3‐month time periods for analysis. The effects of time period, stratification group and stratification group by time period interactions on CD4 counts were tested using a mixed model. Univariate comparisons among patient characteristics and responses were performed using Fisher's exact test or the Wilcoxon rank sum test.
Results
At initiation of TI, the median CD4 count was 799 cells/μL. TI duration was a median of 7.1 months. HIV RNA rebounded to a median maximum level of 75 000 copies/mL. Maximum viral rebound was significantly greater in patients who were male, had lipodystrophy and had zenith HIV RNA prior to TI of ≥50 000 copies/mL. Lower CD4 cell counts were observed during TI in patients with lipodystrophy, zenith HIV RNA ≥50 000 copies/mL, history of AIDS, HIV infection ≥5 years and presuppression CD4 count ≤350 cells/μL. Patients who reinitiated therapy had shorter TI duration, presuppression CD4 count ≤350 cells/μL, previous AIDS diagnosis and lipodystrophy. No patients developed adverse or AIDS‐defining events during TI.
Conclusions
Long‐term TI resulted in greater immune deterioration in patients with high viral set points or low CD4 cell counts prior to initiation of suppressive antiretroviral therapy.</description><subject>Adult</subject><subject>Anti-HIV Agents - administration & dosage</subject><subject>antiretroviral therapy</subject><subject>Antiretroviral Therapy, Highly Active - methods</subject><subject>CD4 Lymphocyte Count</subject><subject>Chronic Disease</subject><subject>chronic HIV</subject><subject>Disease Progression</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - isolation & purification</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>RNA, Viral - blood</subject><subject>treatment interruption</subject><subject>Viral Load</subject><issn>1464-2662</issn><issn>1468-1293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1OFTEUxxuDEURfgXTlbsaeft5J2BCCQkI0Meq26e200pv5su3AZecj-Iw8CR3uDS6lm57m_H7nJP0jhIHUUM7HTQ1criqgDaspIaImhApVb1-ho-fGwVPNKyolPURvU9oQAoo15A06BCEVoVweoe3FNruhdS02Qw7R5Tjehmg6nKMzuXdDxmHILsZ5ymEcygNfXv18-PM3DN7ZXLzJ5FCwhO9CvsHdOPwq3WL0OM3TFF1Kizd6PHUm9WbR8bcvZ-_Qa2-65N7v72P049PF9_PL6vrr56vzs-vKcq5URQW3CuTawZpx4gVQK1atsH6tPJfMEmMBWsop55w0DRPSWt-QgjHilaXsGH3YzZ3i-Ht2Kes-JOu6zgxunJOWiinVAPkvCGoFwAQUcLUDbRxTis7rKYbexHsNRC_x6I1eUtBLCnqJRz_Fo7dFPdnvmNe9a_-J-zwKcLoD7kLn7l88WJdPLQV7BE5hoQE</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Achenbach, CJ</creator><creator>Till, M</creator><creator>Palella, FJ</creator><creator>Knoll, MD</creator><creator>Terp, SM</creator><creator>Kalnins, AU</creator><creator>Murphy, RL</creator><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Extended antiretroviral treatment interruption in HIV‐infected patients with long‐term suppression of plasma HIV RNA</title><author>Achenbach, CJ ; Till, M ; Palella, FJ ; Knoll, MD ; Terp, SM ; Kalnins, AU ; Murphy, RL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4477-254c716be1b340f512c58d5cfb7f463c0ac11d242444099356ccf9012c30f7c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Anti-HIV Agents - administration & dosage</topic><topic>antiretroviral therapy</topic><topic>Antiretroviral Therapy, Highly Active - methods</topic><topic>CD4 Lymphocyte Count</topic><topic>Chronic Disease</topic><topic>chronic HIV</topic><topic>Disease Progression</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - isolation & purification</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>RNA, Viral - blood</topic><topic>treatment interruption</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Achenbach, CJ</creatorcontrib><creatorcontrib>Till, M</creatorcontrib><creatorcontrib>Palella, FJ</creatorcontrib><creatorcontrib>Knoll, MD</creatorcontrib><creatorcontrib>Terp, SM</creatorcontrib><creatorcontrib>Kalnins, AU</creatorcontrib><creatorcontrib>Murphy, RL</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>HIV medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Achenbach, CJ</au><au>Till, M</au><au>Palella, FJ</au><au>Knoll, MD</au><au>Terp, SM</au><au>Kalnins, AU</au><au>Murphy, RL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extended antiretroviral treatment interruption in HIV‐infected patients with long‐term suppression of plasma HIV RNA</atitle><jtitle>HIV medicine</jtitle><addtitle>HIV Med</addtitle><date>2005-01</date><risdate>2005</risdate><volume>6</volume><issue>1</issue><spage>7</spage><epage>12</epage><pages>7-12</pages><issn>1464-2662</issn><eissn>1468-1293</eissn><abstract>Objectives
Evaluation of extended treatment interruption (TI) in chronic HIV infection among patients successfully treated with antiretroviral therapy.
Methods
An observational analysis of 25 patients in a prospectively followed cohort with chronic HIV infection, viral loads <500 HIV‐1 RNA copies/mL for at least 6 months, and an interruption in therapy of ≥28 days duration was carried out. Follow up was divided into 3‐month time periods for analysis. The effects of time period, stratification group and stratification group by time period interactions on CD4 counts were tested using a mixed model. Univariate comparisons among patient characteristics and responses were performed using Fisher's exact test or the Wilcoxon rank sum test.
Results
At initiation of TI, the median CD4 count was 799 cells/μL. TI duration was a median of 7.1 months. HIV RNA rebounded to a median maximum level of 75 000 copies/mL. Maximum viral rebound was significantly greater in patients who were male, had lipodystrophy and had zenith HIV RNA prior to TI of ≥50 000 copies/mL. Lower CD4 cell counts were observed during TI in patients with lipodystrophy, zenith HIV RNA ≥50 000 copies/mL, history of AIDS, HIV infection ≥5 years and presuppression CD4 count ≤350 cells/μL. Patients who reinitiated therapy had shorter TI duration, presuppression CD4 count ≤350 cells/μL, previous AIDS diagnosis and lipodystrophy. No patients developed adverse or AIDS‐defining events during TI.
Conclusions
Long‐term TI resulted in greater immune deterioration in patients with high viral set points or low CD4 cell counts prior to initiation of suppressive antiretroviral therapy.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15670246</pmid><doi>10.1111/j.1468-1293.2005.00257.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1464-2662 |
| ispartof | HIV medicine, 2005-01, Vol.6 (1), p.7-12 |
| issn | 1464-2662 1468-1293 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67377910 |
| source | Wiley Free Content; MEDLINE; IngentaConnect Free/Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Anti-HIV Agents - administration & dosage antiretroviral therapy Antiretroviral Therapy, Highly Active - methods CD4 Lymphocyte Count Chronic Disease chronic HIV Disease Progression Drug Administration Schedule Female Follow-Up Studies HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV-1 - isolation & purification Human immunodeficiency virus 1 Humans Male Middle Aged RNA, Viral - blood treatment interruption Viral Load |
| title | Extended antiretroviral treatment interruption in HIV‐infected patients with long‐term suppression of plasma HIV RNA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T07%3A37%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Extended%20antiretroviral%20treatment%20interruption%20in%20HIV%E2%80%90infected%20patients%20with%20long%E2%80%90term%20suppression%20of%20plasma%20HIV%20RNA&rft.jtitle=HIV%20medicine&rft.au=Achenbach,%20CJ&rft.date=2005-01&rft.volume=6&rft.issue=1&rft.spage=7&rft.epage=12&rft.pages=7-12&rft.issn=1464-2662&rft.eissn=1468-1293&rft_id=info:doi/10.1111/j.1468-1293.2005.00257.x&rft_dat=%3Cproquest_cross%3E17811351%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17811351&rft_id=info:pmid/15670246&rfr_iscdi=true |