The Promise of Immuno-PET in Radioimmunotherapy

Immuno-PET as a quantitative imaging procedure before or concomitant with radioimmunotherapy is an attractive option to improve confirmation of tumor targeting and especially assessment of radiation dose delivery to both tumor and normal tissues. General information about PET, PET systems, and quant...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2005-01, Vol.46 (1 suppl), p.164S-71S
Hauptverfasser:	Verel, Iris, Visser, Gerard W.M, van Dongen, Guus A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - therapeutic use Clinical Trials as Topic Drug Delivery Systems - methods Drug Delivery Systems - trends Humans Neoplasms - diagnostic imaging Neoplasms - radiotherapy Positron-Emission Tomography - methods Positron-Emission Tomography - trends Practice Guidelines as Topic Practice Patterns, Physicians' - trends Prognosis Radioimmunotherapy - methods Radioimmunotherapy - trends Radioisotopes - therapeutic use Radiopharmaceuticals - therapeutic use Treatment Outcome
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Beschreibung
Zusammenfassung:	Immuno-PET as a quantitative imaging procedure before or concomitant with radioimmunotherapy is an attractive option to improve confirmation of tumor targeting and especially assessment of radiation dose delivery to both tumor and normal tissues. General information about PET, PET systems, and quantification is provided in this review. The requirements for an appropriate positron emitter and characteristics of the most attractive candidate emitters for immuno-PET are discussed. An overview of preclinical and clinical immuno-PET studies reported in the literature is provided.
ISSN:	0161-5505 1535-5667