Developing Rat Lung Has a Sided Pacemaker Region for Morphogenesis-Related Airway Peristalsis
Prenatal airways from diverse species are capable of spontaneous peristaltic contractions in each trimester. The function of this smooth muscle activity is unknown. We demonstrate that peristalsis of the embryonic airway originates from a sided pacemaker focus, is stimulated in a calcium-dependent f...
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| Veröffentlicht in: | American journal of respiratory cell and molecular biology 2005-02, Vol.32 (2), p.118-127 |
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| container_title | American journal of respiratory cell and molecular biology |
| container_volume | 32 |
| creator | Jesudason, Edwin C Smith, Nicola P Connell, Marilyn G Spiller, Dave G White, Mike R. H Fernig, Dave G Losty, Paul D |
| description | Prenatal airways from diverse species are capable of spontaneous peristaltic contractions in each trimester. The function of this smooth muscle activity is unknown. We demonstrate that peristalsis of the embryonic airway originates from a sided pacemaker focus, is stimulated in a calcium-dependent fashion by the pulmonary morphogen fibroblast growth factor-10 (FGF-10), and appears coupled to lung growth. Airway peristalsis may be crucial for lung development (thereby providing a physiologic role for airway smooth muscle) and play a hitherto unanticipated role in reported transgenic mutant lung phenotypes. |
| doi_str_mv | 10.1165/rcmb.2004-0304OC |
| format | Article |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Animals Biological Clocks - physiology Calcium - metabolism Fibroblast Growth Factor 10 Fibroblast Growth Factors - metabolism Gene Expression Regulation, Developmental - physiology Immunohistochemistry Lung - embryology Morphogenesis - physiology Muscle Contraction - physiology Muscle, Smooth - physiology Organ Culture Techniques Rats Rats, Sprague-Dawley Respiratory Mechanics - physiology |
| title | Developing Rat Lung Has a Sided Pacemaker Region for Morphogenesis-Related Airway Peristalsis |
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