Preparation and evaluation of a chitosan salt–poloxamer 407 based matrix for buccal drug delivery
The aim of this work was to prepare and evaluate a matrix for buccal drug delivery composed of a chitosan salt and poloxamer 407. Different chitosan salts were formed by reacting chitosan with acetic, citric, and lactic acid. Various proportions of poloxamer 407 were added to the aqueous solution of...
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| Veröffentlicht in: | Journal of controlled release 2005-01, Vol.102 (1), p.159-169 |
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| creator | Cafaggi, S. Leardi, R. Parodi, B. Caviglioli, G. Russo, E. Bignardi, G. |
| description | The aim of this work was to prepare and evaluate a matrix for buccal drug delivery composed of a chitosan salt and poloxamer 407. Different chitosan salts were formed by reacting chitosan with acetic, citric, and lactic acid. Various proportions of poloxamer 407 were added to the aqueous solution of chitosan salt, and the residue obtained by lyophilisation was compressed into discs, using a 30 kN compression force. An experimental design (3
2) was used to study the influence of the type of chitosan salt and of the relative amount of poloxamer on drug release capacity, swelling, erosion, and mucoadhesiveness of matrices.
The results showed that matrix properties depended significantly on both relative amount of poloxamer and chitosan salt type. The rank orders of chitosan salts for the four processes evaluated were as follows: drug release: chitosan acetate>chitosan citrate>chitosan lactate; swelling: chitosan lactate>chitosan acetate=chitosan citrate; erosion: chitosan citrate>chitosan lactate>chitosan acetate; mucoadhesion: chitosan lactate>chitosan acetate=chitosan citrate. Mucoadhesion was particularly favoured when poloxamer 407 was present at about 30% (w/w). The matrix composed of chitosan lactate and poloxamer 407 showed the best characteristics for buccal administration. |
| doi_str_mv | 10.1016/j.jconrel.2004.09.019 |
| format | Article |
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2) was used to study the influence of the type of chitosan salt and of the relative amount of poloxamer on drug release capacity, swelling, erosion, and mucoadhesiveness of matrices.
The results showed that matrix properties depended significantly on both relative amount of poloxamer and chitosan salt type. The rank orders of chitosan salts for the four processes evaluated were as follows: drug release: chitosan acetate>chitosan citrate>chitosan lactate; swelling: chitosan lactate>chitosan acetate=chitosan citrate; erosion: chitosan citrate>chitosan lactate>chitosan acetate; mucoadhesion: chitosan lactate>chitosan acetate=chitosan citrate. Mucoadhesion was particularly favoured when poloxamer 407 was present at about 30% (w/w). The matrix composed of chitosan lactate and poloxamer 407 showed the best characteristics for buccal administration.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2004.09.019</identifier><identifier>PMID: 15653142</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Administration, Buccal ; Animals ; Biological and medical sciences ; Buccal delivery ; Chitosan ; Chitosan - administration & dosage ; Chitosan - chemical synthesis ; Chitosan - pharmacokinetics ; Controlled release ; Drug Delivery Systems - methods ; Drug Evaluation, Preclinical - methods ; General pharmacology ; In Vitro Techniques ; Medical sciences ; Mouth Mucosa - drug effects ; Mouth Mucosa - metabolism ; Mucoadhesion ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Poloxamer - administration & dosage ; Poloxamer - chemical synthesis ; Poloxamer - pharmacokinetics ; Poloxamer 407 ; Swine</subject><ispartof>Journal of controlled release, 2005-01, Vol.102 (1), p.159-169</ispartof><rights>2004 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-e40de7f14b53a6187a25204a9edf1eac0c205e6c4f94365a2cfe6fb92f3f2a7d3</citedby><cites>FETCH-LOGICAL-c424t-e40de7f14b53a6187a25204a9edf1eac0c205e6c4f94365a2cfe6fb92f3f2a7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168365904004493$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16447506$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15653142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cafaggi, S.</creatorcontrib><creatorcontrib>Leardi, R.</creatorcontrib><creatorcontrib>Parodi, B.</creatorcontrib><creatorcontrib>Caviglioli, G.</creatorcontrib><creatorcontrib>Russo, E.</creatorcontrib><creatorcontrib>Bignardi, G.</creatorcontrib><title>Preparation and evaluation of a chitosan salt–poloxamer 407 based matrix for buccal drug delivery</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>The aim of this work was to prepare and evaluate a matrix for buccal drug delivery composed of a chitosan salt and poloxamer 407. Different chitosan salts were formed by reacting chitosan with acetic, citric, and lactic acid. Various proportions of poloxamer 407 were added to the aqueous solution of chitosan salt, and the residue obtained by lyophilisation was compressed into discs, using a 30 kN compression force. An experimental design (3
2) was used to study the influence of the type of chitosan salt and of the relative amount of poloxamer on drug release capacity, swelling, erosion, and mucoadhesiveness of matrices.
The results showed that matrix properties depended significantly on both relative amount of poloxamer and chitosan salt type. The rank orders of chitosan salts for the four processes evaluated were as follows: drug release: chitosan acetate>chitosan citrate>chitosan lactate; swelling: chitosan lactate>chitosan acetate=chitosan citrate; erosion: chitosan citrate>chitosan lactate>chitosan acetate; mucoadhesion: chitosan lactate>chitosan acetate=chitosan citrate. Mucoadhesion was particularly favoured when poloxamer 407 was present at about 30% (w/w). The matrix composed of chitosan lactate and poloxamer 407 showed the best characteristics for buccal administration.</description><subject>Administration, Buccal</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Buccal delivery</subject><subject>Chitosan</subject><subject>Chitosan - administration & dosage</subject><subject>Chitosan - chemical synthesis</subject><subject>Chitosan - pharmacokinetics</subject><subject>Controlled release</subject><subject>Drug Delivery Systems - methods</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>General pharmacology</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Mouth Mucosa - drug effects</subject><subject>Mouth Mucosa - metabolism</subject><subject>Mucoadhesion</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Poloxamer - administration & dosage</subject><subject>Poloxamer - chemical synthesis</subject><subject>Poloxamer - pharmacokinetics</subject><subject>Poloxamer 407</subject><subject>Swine</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhS0EoreFRwB5A7sE27HjeoVQBQWpEixgbU3sMfgqiS92ctXueAfekCfB1Y3UZVejkb75OecQ8oqzljPev9u3e5fmjGMrGJMtMy3j5gnZ8UvdNdIY9ZTsKnfZdL0yZ-S8lD1jTHVSPydnXPWq41LsiPuW8QAZlphmCrOneIRxPbUpUKDuV1xSgZkWGJd_f_4e0phuYcJMJdN0gIKeTrDkeEtDynRYnYOR-rz-pB7HeMR894I8CzAWfLnVC_Lj08fvV5-bm6_XX64-3DROCrk0KJlHHbgcVAd91QFCCSbBoA8cwTEnmMLeyWBkFQXCBezDYEToggDtuwvy9rT3kNPvFctip1gcjiPMmNZie91pLbl8FORaiY4rU0F1Al1OpWQM9pDjBPnOcmbvY7B7u8Vg72OwzNgaQ517vR1Yhwn9w9TmewXebACU6lfIMLtYHrheSq1YX7n3Jw6rb8eI2RYXcXboY0a3WJ_iI6_8B8xKqps</recordid><startdate>20050120</startdate><enddate>20050120</enddate><creator>Cafaggi, S.</creator><creator>Leardi, R.</creator><creator>Parodi, B.</creator><creator>Caviglioli, G.</creator><creator>Russo, E.</creator><creator>Bignardi, G.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050120</creationdate><title>Preparation and evaluation of a chitosan salt–poloxamer 407 based matrix for buccal drug delivery</title><author>Cafaggi, S. ; Leardi, R. ; Parodi, B. ; Caviglioli, G. ; Russo, E. ; Bignardi, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-e40de7f14b53a6187a25204a9edf1eac0c205e6c4f94365a2cfe6fb92f3f2a7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Administration, Buccal</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Buccal delivery</topic><topic>Chitosan</topic><topic>Chitosan - administration & dosage</topic><topic>Chitosan - chemical synthesis</topic><topic>Chitosan - pharmacokinetics</topic><topic>Controlled release</topic><topic>Drug Delivery Systems - methods</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>General pharmacology</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Mouth Mucosa - drug effects</topic><topic>Mouth Mucosa - metabolism</topic><topic>Mucoadhesion</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Poloxamer - administration & dosage</topic><topic>Poloxamer - chemical synthesis</topic><topic>Poloxamer - pharmacokinetics</topic><topic>Poloxamer 407</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cafaggi, S.</creatorcontrib><creatorcontrib>Leardi, R.</creatorcontrib><creatorcontrib>Parodi, B.</creatorcontrib><creatorcontrib>Caviglioli, G.</creatorcontrib><creatorcontrib>Russo, E.</creatorcontrib><creatorcontrib>Bignardi, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cafaggi, S.</au><au>Leardi, R.</au><au>Parodi, B.</au><au>Caviglioli, G.</au><au>Russo, E.</au><au>Bignardi, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and evaluation of a chitosan salt–poloxamer 407 based matrix for buccal drug delivery</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2005-01-20</date><risdate>2005</risdate><volume>102</volume><issue>1</issue><spage>159</spage><epage>169</epage><pages>159-169</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>The aim of this work was to prepare and evaluate a matrix for buccal drug delivery composed of a chitosan salt and poloxamer 407. Different chitosan salts were formed by reacting chitosan with acetic, citric, and lactic acid. Various proportions of poloxamer 407 were added to the aqueous solution of chitosan salt, and the residue obtained by lyophilisation was compressed into discs, using a 30 kN compression force. An experimental design (3
2) was used to study the influence of the type of chitosan salt and of the relative amount of poloxamer on drug release capacity, swelling, erosion, and mucoadhesiveness of matrices.
The results showed that matrix properties depended significantly on both relative amount of poloxamer and chitosan salt type. The rank orders of chitosan salts for the four processes evaluated were as follows: drug release: chitosan acetate>chitosan citrate>chitosan lactate; swelling: chitosan lactate>chitosan acetate=chitosan citrate; erosion: chitosan citrate>chitosan lactate>chitosan acetate; mucoadhesion: chitosan lactate>chitosan acetate=chitosan citrate. Mucoadhesion was particularly favoured when poloxamer 407 was present at about 30% (w/w). The matrix composed of chitosan lactate and poloxamer 407 showed the best characteristics for buccal administration.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15653142</pmid><doi>10.1016/j.jconrel.2004.09.019</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of controlled release, 2005-01, Vol.102 (1), p.159-169 |
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| subjects | Administration, Buccal Animals Biological and medical sciences Buccal delivery Chitosan Chitosan - administration & dosage Chitosan - chemical synthesis Chitosan - pharmacokinetics Controlled release Drug Delivery Systems - methods Drug Evaluation, Preclinical - methods General pharmacology In Vitro Techniques Medical sciences Mouth Mucosa - drug effects Mouth Mucosa - metabolism Mucoadhesion Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poloxamer - administration & dosage Poloxamer - chemical synthesis Poloxamer - pharmacokinetics Poloxamer 407 Swine |
| title | Preparation and evaluation of a chitosan salt–poloxamer 407 based matrix for buccal drug delivery |
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