HLA–B27–restricted antigen presentation by human chondrocytes to CD8+ T cells: Potential contribution to local immunopathologic processes in ankylosing spondylitis

Objective Analysis of the histopathologic features of hip arthritis in patients with ankylosing spondylitis (AS) has revealed accumulation of infiltrating mononuclear cells in the bone end plate and presence of hyaline articular cartilage that is not found in areas of total cartilage destruction. Th...

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Veröffentlicht in:	Arthritis and rheumatism 2009-06, Vol.60 (6), p.1635-1646
Hauptverfasser:	Kuhne, Maren, Erben, Ulrike, Schulze‐Tanzil, Gundula, Köhler, Dorothee, Wu, Peihua, Richter, F. Jan, John, Thilo, Radbruch, Andreas, Sieper, Joachim, Appel, Heiner
Format:	Artikel
Sprache:	eng
Schlagworte:	B7-1 Antigen - metabolism Biological and medical sciences Cartilage, Articular - metabolism Cartilage, Articular - pathology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Cell Communication - physiology Cell Line Cells, Cultured Chondrocytes - drug effects Chondrocytes - metabolism Chondrocytes - pathology Collagen Type II - metabolism Diseases of the osteoarticular system Diseases of the spine Female Granzymes - metabolism HLA-B27 Antigen - metabolism Humans Inflammatory joint diseases Interferon-gamma - pharmacology Medical sciences Middle Aged Perforin - metabolism Spondylitis, Ankylosing - immunology Spondylitis, Ankylosing - pathology Spondylitis, Ankylosing - physiopathology
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