Overexpression of the transcription factor foxo4 is associated with rapid glucose clearance

Leptin treatment ameliorates lipoatrophic diabetes in animal models and humans. Transgenic mice overexpressing leptin (LepTg) are lipoatrophic but not diabetic and thus represent a model for elucidating mechanisms of leptin-mediated glucose homeostasis. In this communication, we show that LepTg mice...

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Veröffentlicht in:	Molecular and cellular endocrinology 2009-08, Vol.307 (1-2), p.217-223
Hauptverfasser:	Wang, Biao, Zhu, Jun, Mounzih, Khalid, Chehab, Eric F., Ke, Yaohuang, Chehab, Farid F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - metabolism Adipose tissue Adipose Tissue, White - enzymology AMP-Activated Protein Kinases - metabolism AMPK Animals Enzyme Activation Female Forkhead Transcription Factors - metabolism Foxo4 Glucose Glucose - metabolism Glucose Tolerance Test Growth and Development Leptin Leptin - metabolism Male Mice Mice, Transgenic MnSOD Mutation - genetics Phosphorylation Proto-Oncogene Proteins c-akt - metabolism
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