Halothane modulates NMDA and non-NMDA excitatory synaptic transmission in rat cortical neurons

Although general anesthetics may decrease neuronal excitation, their detailed effects on spontaneous excitatory postsynaptic currents (EPSCs) remain controversial. We investigated and compared the effects of halothane on N-methyl-D-asparate (NMDA) and non-NMDA receptor-mediated postsynaptic currents...

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Veröffentlicht in:	Journal of anesthesia 2005-02, Vol.19 (1), p.66-72
Hauptverfasser:	Kitamura, Akira, Satoh, Ryoichi, Nagano, Tomoo, Matsuda, Hiroyuki, Shimizu, Toru, Sakamoto, Atsuhiro, Ogawa, Ryo
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Anesthetics, Inhalation - pharmacology Animals Causes of Cerebral Cortex - cytology Cerebral Cortex - drug effects Dosage and administration Electrophysiology Excitatory Postsynaptic Potentials - drug effects gamma-Aminobutyric Acid - physiology Glutamates - physiology Halothane Halothane - pharmacology Health aspects Kinetics Membrane Potentials - drug effects Methyl aspartate Neurons - drug effects Patch-Clamp Techniques Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - drug effects Synapses Synaptic Transmission - drug effects
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