Gene expression profiling in chronic inflammatory demyelinating polyneuropathy
Gene expression in archived frozen sural nerve biopsies of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) was compared to that in vasculitic nerve biopsies (VAS) and to normal nerve (NN) by DNA microarray technology. Hierarchical clustering analysis demonstrated distinct gene...
Gespeichert in:
| Veröffentlicht in: | Journal of neuroimmunology 2005-02, Vol.159 (1), p.203-214 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 214 |
|---|---|
| container_issue | 1 |
| container_start_page | 203 |
| container_title | Journal of neuroimmunology |
| container_volume | 159 |
| creator | Renaud, Susanne Hays, Arthur P. Brannagan, Thomas H. Sander, Howard W. Edgar, Mark Weimer, Louis H. Olarte, Marcelo R. Dalakas, Marinos C. Xiang, Zhaoying Danon, Moris J. Latov, Norman |
| description | Gene expression in archived frozen sural nerve biopsies of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) was compared to that in vasculitic nerve biopsies (VAS) and to normal nerve (NN) by DNA microarray technology. Hierarchical clustering analysis demonstrated distinct gene expression patterns distinguishing these disease groups. Of particular interest were: (1) Tachykinin precursor 1, which may be involved in pain mediation; (2) Stearoyl-CoA-desaturase, which may be a marker for remyelination and (3) the Allograft Inflammatory Factor 1 (AIF-1), a modulator of immune response during macrophage activation. Differential gene expression may help distinguish between CIDP, VAS and NN in sural nerve biopsies and identify genes that may be involved in disease pathogenesis. |
| doi_str_mv | 10.1016/j.jneuroim.2004.10.021 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67376573</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165572804003698</els_id><sourcerecordid>19543968</sourcerecordid><originalsourceid>FETCH-LOGICAL-c428t-3114f3396b473012f7e1950cee51c5bcffeca61c673cd9b2164dff2b3775d8f93</originalsourceid><addsrcrecordid>eNqFkU9P4zAQxS0EWgq7X6HKiVuKx3_i5AZCLIuE4MKercQZb10lcdZOEfn2uLSIY09jjX5v3pMfIUugK6BQXG9WmwG3wbt-xSgVabmiDE7IAkrF8lIwOCWLBMpcKlaek4sYN5SC5KL6Qc5BFpIlZkGeH3DADN_HgDE6P2Rj8NZ1bviXuSEz6-AHZ9LTdnXf15MPc9ZiP2Mi6mlHjb6bP5OM9bSef5IzW3cRfx3mJfn7-_717k_-9PLweHf7lBvByinnAMJyXhWNUJwCswqhktQgSjCyMdaiqQswheKmrRoGhWitZQ1XSralrfgludrfTXH_bzFOunfRYNfVA_pt1EmoCqn4UTDZipSjPA4qLqQQkMBiD5rgYwxo9RhcX4dZA9W7bvRGf3Wjd93s9qmbJFweHLZNj-237FBGAm72AKafe3MYdDQOB4OtC2gm3Xp3zOMDAgqlHQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17345441</pqid></control><display><type>article</type><title>Gene expression profiling in chronic inflammatory demyelinating polyneuropathy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Renaud, Susanne ; Hays, Arthur P. ; Brannagan, Thomas H. ; Sander, Howard W. ; Edgar, Mark ; Weimer, Louis H. ; Olarte, Marcelo R. ; Dalakas, Marinos C. ; Xiang, Zhaoying ; Danon, Moris J. ; Latov, Norman</creator><creatorcontrib>Renaud, Susanne ; Hays, Arthur P. ; Brannagan, Thomas H. ; Sander, Howard W. ; Edgar, Mark ; Weimer, Louis H. ; Olarte, Marcelo R. ; Dalakas, Marinos C. ; Xiang, Zhaoying ; Danon, Moris J. ; Latov, Norman</creatorcontrib><description>Gene expression in archived frozen sural nerve biopsies of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) was compared to that in vasculitic nerve biopsies (VAS) and to normal nerve (NN) by DNA microarray technology. Hierarchical clustering analysis demonstrated distinct gene expression patterns distinguishing these disease groups. Of particular interest were: (1) Tachykinin precursor 1, which may be involved in pain mediation; (2) Stearoyl-CoA-desaturase, which may be a marker for remyelination and (3) the Allograft Inflammatory Factor 1 (AIF-1), a modulator of immune response during macrophage activation. Differential gene expression may help distinguish between CIDP, VAS and NN in sural nerve biopsies and identify genes that may be involved in disease pathogenesis.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2004.10.021</identifier><identifier>PMID: 15652421</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; AIF-1 ; Chronic Disease ; CIDP ; Demyelinating Diseases - genetics ; Demyelinating Diseases - pathology ; Female ; Gene Expression Profiling - methods ; Humans ; Male ; Microarray ; Middle Aged ; Nerve biopsy ; Oligonucleotide Array Sequence Analysis - methods ; Polyneuropathies - genetics ; Polyneuropathies - pathology ; Reverse Transcriptase Polymerase Chain Reaction ; SCD ; Signal Transduction - genetics ; Sural Nerve - pathology ; TAC1 ; Up-Regulation ; Vasculitic neuropathy</subject><ispartof>Journal of neuroimmunology, 2005-02, Vol.159 (1), p.203-214</ispartof><rights>2004 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-3114f3396b473012f7e1950cee51c5bcffeca61c673cd9b2164dff2b3775d8f93</citedby><cites>FETCH-LOGICAL-c428t-3114f3396b473012f7e1950cee51c5bcffeca61c673cd9b2164dff2b3775d8f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165572804003698$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15652421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Renaud, Susanne</creatorcontrib><creatorcontrib>Hays, Arthur P.</creatorcontrib><creatorcontrib>Brannagan, Thomas H.</creatorcontrib><creatorcontrib>Sander, Howard W.</creatorcontrib><creatorcontrib>Edgar, Mark</creatorcontrib><creatorcontrib>Weimer, Louis H.</creatorcontrib><creatorcontrib>Olarte, Marcelo R.</creatorcontrib><creatorcontrib>Dalakas, Marinos C.</creatorcontrib><creatorcontrib>Xiang, Zhaoying</creatorcontrib><creatorcontrib>Danon, Moris J.</creatorcontrib><creatorcontrib>Latov, Norman</creatorcontrib><title>Gene expression profiling in chronic inflammatory demyelinating polyneuropathy</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Gene expression in archived frozen sural nerve biopsies of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) was compared to that in vasculitic nerve biopsies (VAS) and to normal nerve (NN) by DNA microarray technology. Hierarchical clustering analysis demonstrated distinct gene expression patterns distinguishing these disease groups. Of particular interest were: (1) Tachykinin precursor 1, which may be involved in pain mediation; (2) Stearoyl-CoA-desaturase, which may be a marker for remyelination and (3) the Allograft Inflammatory Factor 1 (AIF-1), a modulator of immune response during macrophage activation. Differential gene expression may help distinguish between CIDP, VAS and NN in sural nerve biopsies and identify genes that may be involved in disease pathogenesis.</description><subject>Adult</subject><subject>Aged</subject><subject>AIF-1</subject><subject>Chronic Disease</subject><subject>CIDP</subject><subject>Demyelinating Diseases - genetics</subject><subject>Demyelinating Diseases - pathology</subject><subject>Female</subject><subject>Gene Expression Profiling - methods</subject><subject>Humans</subject><subject>Male</subject><subject>Microarray</subject><subject>Middle Aged</subject><subject>Nerve biopsy</subject><subject>Oligonucleotide Array Sequence Analysis - methods</subject><subject>Polyneuropathies - genetics</subject><subject>Polyneuropathies - pathology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>SCD</subject><subject>Signal Transduction - genetics</subject><subject>Sural Nerve - pathology</subject><subject>TAC1</subject><subject>Up-Regulation</subject><subject>Vasculitic neuropathy</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9P4zAQxS0EWgq7X6HKiVuKx3_i5AZCLIuE4MKercQZb10lcdZOEfn2uLSIY09jjX5v3pMfIUugK6BQXG9WmwG3wbt-xSgVabmiDE7IAkrF8lIwOCWLBMpcKlaek4sYN5SC5KL6Qc5BFpIlZkGeH3DADN_HgDE6P2Rj8NZ1bviXuSEz6-AHZ9LTdnXf15MPc9ZiP2Mi6mlHjb6bP5OM9bSef5IzW3cRfx3mJfn7-_717k_-9PLweHf7lBvByinnAMJyXhWNUJwCswqhktQgSjCyMdaiqQswheKmrRoGhWitZQ1XSralrfgludrfTXH_bzFOunfRYNfVA_pt1EmoCqn4UTDZipSjPA4qLqQQkMBiD5rgYwxo9RhcX4dZA9W7bvRGf3Wjd93s9qmbJFweHLZNj-237FBGAm72AKafe3MYdDQOB4OtC2gm3Xp3zOMDAgqlHQ</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Renaud, Susanne</creator><creator>Hays, Arthur P.</creator><creator>Brannagan, Thomas H.</creator><creator>Sander, Howard W.</creator><creator>Edgar, Mark</creator><creator>Weimer, Louis H.</creator><creator>Olarte, Marcelo R.</creator><creator>Dalakas, Marinos C.</creator><creator>Xiang, Zhaoying</creator><creator>Danon, Moris J.</creator><creator>Latov, Norman</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>Gene expression profiling in chronic inflammatory demyelinating polyneuropathy</title><author>Renaud, Susanne ; Hays, Arthur P. ; Brannagan, Thomas H. ; Sander, Howard W. ; Edgar, Mark ; Weimer, Louis H. ; Olarte, Marcelo R. ; Dalakas, Marinos C. ; Xiang, Zhaoying ; Danon, Moris J. ; Latov, Norman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-3114f3396b473012f7e1950cee51c5bcffeca61c673cd9b2164dff2b3775d8f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>AIF-1</topic><topic>Chronic Disease</topic><topic>CIDP</topic><topic>Demyelinating Diseases - genetics</topic><topic>Demyelinating Diseases - pathology</topic><topic>Female</topic><topic>Gene Expression Profiling - methods</topic><topic>Humans</topic><topic>Male</topic><topic>Microarray</topic><topic>Middle Aged</topic><topic>Nerve biopsy</topic><topic>Oligonucleotide Array Sequence Analysis - methods</topic><topic>Polyneuropathies - genetics</topic><topic>Polyneuropathies - pathology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>SCD</topic><topic>Signal Transduction - genetics</topic><topic>Sural Nerve - pathology</topic><topic>TAC1</topic><topic>Up-Regulation</topic><topic>Vasculitic neuropathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Renaud, Susanne</creatorcontrib><creatorcontrib>Hays, Arthur P.</creatorcontrib><creatorcontrib>Brannagan, Thomas H.</creatorcontrib><creatorcontrib>Sander, Howard W.</creatorcontrib><creatorcontrib>Edgar, Mark</creatorcontrib><creatorcontrib>Weimer, Louis H.</creatorcontrib><creatorcontrib>Olarte, Marcelo R.</creatorcontrib><creatorcontrib>Dalakas, Marinos C.</creatorcontrib><creatorcontrib>Xiang, Zhaoying</creatorcontrib><creatorcontrib>Danon, Moris J.</creatorcontrib><creatorcontrib>Latov, Norman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Renaud, Susanne</au><au>Hays, Arthur P.</au><au>Brannagan, Thomas H.</au><au>Sander, Howard W.</au><au>Edgar, Mark</au><au>Weimer, Louis H.</au><au>Olarte, Marcelo R.</au><au>Dalakas, Marinos C.</au><au>Xiang, Zhaoying</au><au>Danon, Moris J.</au><au>Latov, Norman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene expression profiling in chronic inflammatory demyelinating polyneuropathy</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>159</volume><issue>1</issue><spage>203</spage><epage>214</epage><pages>203-214</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Gene expression in archived frozen sural nerve biopsies of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) was compared to that in vasculitic nerve biopsies (VAS) and to normal nerve (NN) by DNA microarray technology. Hierarchical clustering analysis demonstrated distinct gene expression patterns distinguishing these disease groups. Of particular interest were: (1) Tachykinin precursor 1, which may be involved in pain mediation; (2) Stearoyl-CoA-desaturase, which may be a marker for remyelination and (3) the Allograft Inflammatory Factor 1 (AIF-1), a modulator of immune response during macrophage activation. Differential gene expression may help distinguish between CIDP, VAS and NN in sural nerve biopsies and identify genes that may be involved in disease pathogenesis.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>15652421</pmid><doi>10.1016/j.jneuroim.2004.10.021</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 2005-02, Vol.159 (1), p.203-214 |
| issn | 0165-5728 1872-8421 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67376573 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Aged AIF-1 Chronic Disease CIDP Demyelinating Diseases - genetics Demyelinating Diseases - pathology Female Gene Expression Profiling - methods Humans Male Microarray Middle Aged Nerve biopsy Oligonucleotide Array Sequence Analysis - methods Polyneuropathies - genetics Polyneuropathies - pathology Reverse Transcriptase Polymerase Chain Reaction SCD Signal Transduction - genetics Sural Nerve - pathology TAC1 Up-Regulation Vasculitic neuropathy |
| title | Gene expression profiling in chronic inflammatory demyelinating polyneuropathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T20%3A41%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gene%20expression%20profiling%20in%20chronic%20inflammatory%20demyelinating%20polyneuropathy&rft.jtitle=Journal%20of%20neuroimmunology&rft.au=Renaud,%20Susanne&rft.date=2005-02-01&rft.volume=159&rft.issue=1&rft.spage=203&rft.epage=214&rft.pages=203-214&rft.issn=0165-5728&rft.eissn=1872-8421&rft_id=info:doi/10.1016/j.jneuroim.2004.10.021&rft_dat=%3Cproquest_cross%3E19543968%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17345441&rft_id=info:pmid/15652421&rft_els_id=S0165572804003698&rfr_iscdi=true |