Anti‐tumour response despite loss of donor chimaerism in patients treated with non‐myeloablative conditioning and allogeneic stem cell transplantation

Summary Based on a murine model, we conducted a series of trials of m‐myeloablative human leucocyte antigen (HLA)‐matched or mismatched related donor stem cell transplantation (SCT) with the intention of inducing mixed chimaerism (MC), then administering prophylactic donor lymphocyte infusions (DLIs...

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Veröffentlicht in:	British journal of haematology 2005-02, Vol.128 (3), p.351-359
Hauptverfasser:	Dey, Bimalangshu R., McAfee, Steven, Colby, Christine, Cieply, Kathy, Caron, Martin, Saidman, Susan, Preffer, Frederic, Shaffer, Juanita, Tarbell, Nancy, Sackstein, Robert, Sachs, David, Sykes, Megan, Spitzer, Thomas R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult allogeneic Biological and medical sciences chimaerism conditioning Graft Rejection Graft vs Host Disease - diagnostic imaging Graft vs Host Disease - prevention & control Hematologic and hematopoietic diseases Hematologic Neoplasms - immunology Hematologic Neoplasms - physiopathology Hematologic Neoplasms - therapy Hematology Hematopoiesis Hematopoietic Stem Cell Transplantation Humans In Situ Hybridization, Fluorescence Lymphocyte Transfusion Medical sciences Middle Aged non‐myeloablative Radionuclide Imaging Remission Induction stem cell transplant Transplantation Chimera Transplantation Conditioning - methods Treatment Outcome
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