Imatinib attenuates diabetic nephropathy in apolipoprotein E-knockout mice

In the diabetic kidney, clinical as well as experimental observations have shown an upregulation of growth factors such as PDGF. These studies, however, were not designed to address whether upregulation of PDGF is merely a manifestation of diabetic renal injury or whether PDGF plays an active role i...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2005-02, Vol.16 (2), p.363-373
Hauptverfasser:	LASSILA, Markus, JANDELEIT-DAHM, Karin, SEAH, Kwee K, SMITH, Craig M, CALKIN, Anna C, ALLEN, Terri J, COOPER, Mark E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E Associated diseases and complications Base Sequence Benzamides Biological and medical sciences Biopsy, Needle Diabetes. Impaired glucose tolerance Diabetic Nephropathies - drug therapy Diabetic Nephropathies - pathology Disease Models, Animal Endocrine pancreas. Apud cells (diseases) Endocrinopathies Gene Expression Regulation Imatinib Mesylate Immunohistochemistry Kidney Function Tests Kidneys Male Medical sciences Mice Mice, Knockout Molecular Sequence Data Nephrology. Urinary tract diseases Piperazines - pharmacology Pyrimidines - pharmacology Receptor, Platelet-Derived Growth Factor beta - drug effects Receptor, Platelet-Derived Growth Factor beta - metabolism Reference Values Reverse Transcriptase Polymerase Chain Reaction Sensitivity and Specificity Transforming Growth Factor beta - drug effects Transforming Growth Factor beta - metabolism Urinary system involvement in other diseases. Miscellaneous
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