Prognostic significance of parapharyngeal space venous plexus and marrow involvement: Potential landmarks of dissemination for stage I-III nasopharyngeal carcinoma
To determine whether the parapharyngeal space venous plexus and marrow of the skull base bones are anatomic landmarks of the potential routes for the spread of disease for Stage I-III (American Joint Commission on Cancer 1997 staging system) nasopharyngeal carcinoma (NPC). A total of 364 patients wi...
Gespeichert in:
| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2005-02, Vol.61 (2), p.456-465 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 465 |
|---|---|
| container_issue | 2 |
| container_start_page | 456 |
| container_title | International journal of radiation oncology, biology, physics |
| container_volume | 61 |
| creator | Cheng, Skye Hongiun Tsai, Stella Y.C. Yen, K.Lawrence Jian, James Jer-Min Feng, An-Chen Chan, Kwan-Yee Hong, Cheng-Fang Chu, Nei-Min Lin, Yen-Chun Lin, Chin-Yen Tan, Tran-Der Hsieh, Cheng-Yee Chong, Vincent Huang, Andrew T. |
| description | To determine whether the parapharyngeal space venous plexus and marrow of the skull base bones are anatomic landmarks of the potential routes for the spread of disease for Stage I-III (American Joint Commission on Cancer 1997 staging system) nasopharyngeal carcinoma (NPC).
A total of 364 patients with NPC were enrolled in this study. The selection criteria were Stage I-III disease and primary radiotherapy at our hospital between 1990 and 2001. All patients had undergone MRI to evaluate the head-and-neck tumors. Patients who had undergone inadequate radiotherapy at a dose of |
| doi_str_mv | 10.1016/j.ijrobp.2004.05.047 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67375499</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0360301604009381</els_id><sourcerecordid>67375499</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-1dbd8aed367bb30dcd8a6157d512c12154dc257111c75c4ba8ad9f2b2af526f93</originalsourceid><addsrcrecordid>eNp9kUFv1DAUhC1ERZfCP0CVT9yS2klsb3pAQhXQSJXooUjcrBf7ZfGS2KmdXejv4Y_i1a5UTpxGtr6Zp9EQ8o6zkjMur7al28bQz2XFWFMyUbJGvSArvlZtUQvx_SVZsVqyos7wOXmd0pYxxrlqXpFzLqRUrVQr8uc-ho0PaXGGJrfxbnAGvEEaBjpDhPkHxCe_QRhpmiH_79GHXaLziL-zgLd0ghjDL-r8Pox7nNAv1_Q-LFlddo0ZycTPdEi0LiWcnIfFBU-HEGlaYIO0K7quox5S-OeegWicDxO8IWcDjAnfnvSCfPv86eHmtrj7-qW7-XhXmKaSS8Ftb9eAtpaq72tmTX5JLpQVvDK84qKxphKKc26UME0Pa7DtUPUVDKKSQ1tfkPfH3DmGxx2mRU8uGRxzBcydtVS1Ek17AJsjaGJIKeKg5-hyySfNmT6Mo7f6OI4-jKOZ0HmcbLs85e_6Ce2z6bRGBj4cAcwt9w6jTsZhXsO6iGbRNrj_X_gLP5in4g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67375499</pqid></control><display><type>article</type><title>Prognostic significance of parapharyngeal space venous plexus and marrow involvement: Potential landmarks of dissemination for stage I-III nasopharyngeal carcinoma</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Cheng, Skye Hongiun ; Tsai, Stella Y.C. ; Yen, K.Lawrence ; Jian, James Jer-Min ; Feng, An-Chen ; Chan, Kwan-Yee ; Hong, Cheng-Fang ; Chu, Nei-Min ; Lin, Yen-Chun ; Lin, Chin-Yen ; Tan, Tran-Der ; Hsieh, Cheng-Yee ; Chong, Vincent ; Huang, Andrew T.</creator><creatorcontrib>Cheng, Skye Hongiun ; Tsai, Stella Y.C. ; Yen, K.Lawrence ; Jian, James Jer-Min ; Feng, An-Chen ; Chan, Kwan-Yee ; Hong, Cheng-Fang ; Chu, Nei-Min ; Lin, Yen-Chun ; Lin, Chin-Yen ; Tan, Tran-Der ; Hsieh, Cheng-Yee ; Chong, Vincent ; Huang, Andrew T.</creatorcontrib><description>To determine whether the parapharyngeal space venous plexus and marrow of the skull base bones are anatomic landmarks of the potential routes for the spread of disease for Stage I-III (American Joint Commission on Cancer 1997 staging system) nasopharyngeal carcinoma (NPC).
A total of 364 patients with NPC were enrolled in this study. The selection criteria were Stage I-III disease and primary radiotherapy at our hospital between 1990 and 2001. All patients had undergone MRI to evaluate the head-and-neck tumors. Patients who had undergone inadequate radiotherapy at a dose of <60 Gy and/or preradiotherapy chemotherapy before the imaging evaluation were excluded from the study.
Of the 364 patients treated between 1990 and 2001, 163 (44.8%) had low-risk Stage I-III NPC (without parapharyngeal space extension or T3 disease). The 5-year distant metastasis-free survival rate, with and without adjuvant chemotherapy, was 97% and 96%, respectively. The remaining 201 patients had Stage II-III with parapharyngeal space extension or T3 disease. Their 5-year recurrence-free survival rate, with and without adjuvant chemotherapy, was 76.8% and 53.2% (
p = 0.01), respectively.
Our findings suggest that the risk of distant metastasis in Stage I-III NPC patients without parapharyngeal space extension or T3 disease is extremely low. Invasion into the parapharyngeal space venous plexus and marrow of the skull base bones is associated with distant metastasis, and involvement of these anatomic sites is considered a potential route for hematogenous disease spread in patients with Stage I-III NPC.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2004.05.047</identifier><identifier>PMID: 15667967</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Chemotherapy ; Chemotherapy, Adjuvant ; Cisplatin - administration & dosage ; Distant metastasis ; Failure patterns ; Female ; Fluorouracil - administration & dosage ; Humans ; Male ; Middle Aged ; Nasopharyngeal carcinoma ; Nasopharyngeal Neoplasms - drug therapy ; Nasopharyngeal Neoplasms - pathology ; Nasopharyngeal Neoplasms - radiotherapy ; Neoplasm Invasiveness ; Neoplasm Metastasis - prevention & control ; Neoplasm Staging ; Pharynx ; Practice Guidelines as Topic ; Prognosis ; Proportional Hazards Models ; Radiotherapy ; Survival Rate ; Treatment Failure</subject><ispartof>International journal of radiation oncology, biology, physics, 2005-02, Vol.61 (2), p.456-465</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-1dbd8aed367bb30dcd8a6157d512c12154dc257111c75c4ba8ad9f2b2af526f93</citedby><cites>FETCH-LOGICAL-c426t-1dbd8aed367bb30dcd8a6157d512c12154dc257111c75c4ba8ad9f2b2af526f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0360301604009381$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15667967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Skye Hongiun</creatorcontrib><creatorcontrib>Tsai, Stella Y.C.</creatorcontrib><creatorcontrib>Yen, K.Lawrence</creatorcontrib><creatorcontrib>Jian, James Jer-Min</creatorcontrib><creatorcontrib>Feng, An-Chen</creatorcontrib><creatorcontrib>Chan, Kwan-Yee</creatorcontrib><creatorcontrib>Hong, Cheng-Fang</creatorcontrib><creatorcontrib>Chu, Nei-Min</creatorcontrib><creatorcontrib>Lin, Yen-Chun</creatorcontrib><creatorcontrib>Lin, Chin-Yen</creatorcontrib><creatorcontrib>Tan, Tran-Der</creatorcontrib><creatorcontrib>Hsieh, Cheng-Yee</creatorcontrib><creatorcontrib>Chong, Vincent</creatorcontrib><creatorcontrib>Huang, Andrew T.</creatorcontrib><title>Prognostic significance of parapharyngeal space venous plexus and marrow involvement: Potential landmarks of dissemination for stage I-III nasopharyngeal carcinoma</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>To determine whether the parapharyngeal space venous plexus and marrow of the skull base bones are anatomic landmarks of the potential routes for the spread of disease for Stage I-III (American Joint Commission on Cancer 1997 staging system) nasopharyngeal carcinoma (NPC).
A total of 364 patients with NPC were enrolled in this study. The selection criteria were Stage I-III disease and primary radiotherapy at our hospital between 1990 and 2001. All patients had undergone MRI to evaluate the head-and-neck tumors. Patients who had undergone inadequate radiotherapy at a dose of <60 Gy and/or preradiotherapy chemotherapy before the imaging evaluation were excluded from the study.
Of the 364 patients treated between 1990 and 2001, 163 (44.8%) had low-risk Stage I-III NPC (without parapharyngeal space extension or T3 disease). The 5-year distant metastasis-free survival rate, with and without adjuvant chemotherapy, was 97% and 96%, respectively. The remaining 201 patients had Stage II-III with parapharyngeal space extension or T3 disease. Their 5-year recurrence-free survival rate, with and without adjuvant chemotherapy, was 76.8% and 53.2% (
p = 0.01), respectively.
Our findings suggest that the risk of distant metastasis in Stage I-III NPC patients without parapharyngeal space extension or T3 disease is extremely low. Invasion into the parapharyngeal space venous plexus and marrow of the skull base bones is associated with distant metastasis, and involvement of these anatomic sites is considered a potential route for hematogenous disease spread in patients with Stage I-III NPC.</description><subject>Adult</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Cisplatin - administration & dosage</subject><subject>Distant metastasis</subject><subject>Failure patterns</subject><subject>Female</subject><subject>Fluorouracil - administration & dosage</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nasopharyngeal carcinoma</subject><subject>Nasopharyngeal Neoplasms - drug therapy</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Nasopharyngeal Neoplasms - radiotherapy</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Metastasis - prevention & control</subject><subject>Neoplasm Staging</subject><subject>Pharynx</subject><subject>Practice Guidelines as Topic</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Radiotherapy</subject><subject>Survival Rate</subject><subject>Treatment Failure</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAUhC1ERZfCP0CVT9yS2klsb3pAQhXQSJXooUjcrBf7ZfGS2KmdXejv4Y_i1a5UTpxGtr6Zp9EQ8o6zkjMur7al28bQz2XFWFMyUbJGvSArvlZtUQvx_SVZsVqyos7wOXmd0pYxxrlqXpFzLqRUrVQr8uc-ho0PaXGGJrfxbnAGvEEaBjpDhPkHxCe_QRhpmiH_79GHXaLziL-zgLd0ghjDL-r8Pox7nNAv1_Q-LFlddo0ZycTPdEi0LiWcnIfFBU-HEGlaYIO0K7quox5S-OeegWicDxO8IWcDjAnfnvSCfPv86eHmtrj7-qW7-XhXmKaSS8Ftb9eAtpaq72tmTX5JLpQVvDK84qKxphKKc26UME0Pa7DtUPUVDKKSQ1tfkPfH3DmGxx2mRU8uGRxzBcydtVS1Ek17AJsjaGJIKeKg5-hyySfNmT6Mo7f6OI4-jKOZ0HmcbLs85e_6Ce2z6bRGBj4cAcwt9w6jTsZhXsO6iGbRNrj_X_gLP5in4g</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Cheng, Skye Hongiun</creator><creator>Tsai, Stella Y.C.</creator><creator>Yen, K.Lawrence</creator><creator>Jian, James Jer-Min</creator><creator>Feng, An-Chen</creator><creator>Chan, Kwan-Yee</creator><creator>Hong, Cheng-Fang</creator><creator>Chu, Nei-Min</creator><creator>Lin, Yen-Chun</creator><creator>Lin, Chin-Yen</creator><creator>Tan, Tran-Der</creator><creator>Hsieh, Cheng-Yee</creator><creator>Chong, Vincent</creator><creator>Huang, Andrew T.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>Prognostic significance of parapharyngeal space venous plexus and marrow involvement: Potential landmarks of dissemination for stage I-III nasopharyngeal carcinoma</title><author>Cheng, Skye Hongiun ; Tsai, Stella Y.C. ; Yen, K.Lawrence ; Jian, James Jer-Min ; Feng, An-Chen ; Chan, Kwan-Yee ; Hong, Cheng-Fang ; Chu, Nei-Min ; Lin, Yen-Chun ; Lin, Chin-Yen ; Tan, Tran-Der ; Hsieh, Cheng-Yee ; Chong, Vincent ; Huang, Andrew T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-1dbd8aed367bb30dcd8a6157d512c12154dc257111c75c4ba8ad9f2b2af526f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Chemotherapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Cisplatin - administration & dosage</topic><topic>Distant metastasis</topic><topic>Failure patterns</topic><topic>Female</topic><topic>Fluorouracil - administration & dosage</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nasopharyngeal carcinoma</topic><topic>Nasopharyngeal Neoplasms - drug therapy</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Nasopharyngeal Neoplasms - radiotherapy</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Metastasis - prevention & control</topic><topic>Neoplasm Staging</topic><topic>Pharynx</topic><topic>Practice Guidelines as Topic</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Radiotherapy</topic><topic>Survival Rate</topic><topic>Treatment Failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Skye Hongiun</creatorcontrib><creatorcontrib>Tsai, Stella Y.C.</creatorcontrib><creatorcontrib>Yen, K.Lawrence</creatorcontrib><creatorcontrib>Jian, James Jer-Min</creatorcontrib><creatorcontrib>Feng, An-Chen</creatorcontrib><creatorcontrib>Chan, Kwan-Yee</creatorcontrib><creatorcontrib>Hong, Cheng-Fang</creatorcontrib><creatorcontrib>Chu, Nei-Min</creatorcontrib><creatorcontrib>Lin, Yen-Chun</creatorcontrib><creatorcontrib>Lin, Chin-Yen</creatorcontrib><creatorcontrib>Tan, Tran-Der</creatorcontrib><creatorcontrib>Hsieh, Cheng-Yee</creatorcontrib><creatorcontrib>Chong, Vincent</creatorcontrib><creatorcontrib>Huang, Andrew T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Skye Hongiun</au><au>Tsai, Stella Y.C.</au><au>Yen, K.Lawrence</au><au>Jian, James Jer-Min</au><au>Feng, An-Chen</au><au>Chan, Kwan-Yee</au><au>Hong, Cheng-Fang</au><au>Chu, Nei-Min</au><au>Lin, Yen-Chun</au><au>Lin, Chin-Yen</au><au>Tan, Tran-Der</au><au>Hsieh, Cheng-Yee</au><au>Chong, Vincent</au><au>Huang, Andrew T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of parapharyngeal space venous plexus and marrow involvement: Potential landmarks of dissemination for stage I-III nasopharyngeal carcinoma</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>61</volume><issue>2</issue><spage>456</spage><epage>465</epage><pages>456-465</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>To determine whether the parapharyngeal space venous plexus and marrow of the skull base bones are anatomic landmarks of the potential routes for the spread of disease for Stage I-III (American Joint Commission on Cancer 1997 staging system) nasopharyngeal carcinoma (NPC).
A total of 364 patients with NPC were enrolled in this study. The selection criteria were Stage I-III disease and primary radiotherapy at our hospital between 1990 and 2001. All patients had undergone MRI to evaluate the head-and-neck tumors. Patients who had undergone inadequate radiotherapy at a dose of <60 Gy and/or preradiotherapy chemotherapy before the imaging evaluation were excluded from the study.
Of the 364 patients treated between 1990 and 2001, 163 (44.8%) had low-risk Stage I-III NPC (without parapharyngeal space extension or T3 disease). The 5-year distant metastasis-free survival rate, with and without adjuvant chemotherapy, was 97% and 96%, respectively. The remaining 201 patients had Stage II-III with parapharyngeal space extension or T3 disease. Their 5-year recurrence-free survival rate, with and without adjuvant chemotherapy, was 76.8% and 53.2% (
p = 0.01), respectively.
Our findings suggest that the risk of distant metastasis in Stage I-III NPC patients without parapharyngeal space extension or T3 disease is extremely low. Invasion into the parapharyngeal space venous plexus and marrow of the skull base bones is associated with distant metastasis, and involvement of these anatomic sites is considered a potential route for hematogenous disease spread in patients with Stage I-III NPC.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15667967</pmid><doi>10.1016/j.ijrobp.2004.05.047</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-3016 |
| ispartof | International journal of radiation oncology, biology, physics, 2005-02, Vol.61 (2), p.456-465 |
| issn | 0360-3016 1879-355X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67375499 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Chemotherapy Chemotherapy, Adjuvant Cisplatin - administration & dosage Distant metastasis Failure patterns Female Fluorouracil - administration & dosage Humans Male Middle Aged Nasopharyngeal carcinoma Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - radiotherapy Neoplasm Invasiveness Neoplasm Metastasis - prevention & control Neoplasm Staging Pharynx Practice Guidelines as Topic Prognosis Proportional Hazards Models Radiotherapy Survival Rate Treatment Failure |
| title | Prognostic significance of parapharyngeal space venous plexus and marrow involvement: Potential landmarks of dissemination for stage I-III nasopharyngeal carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T00%3A43%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20significance%20of%20parapharyngeal%20space%20venous%20plexus%20and%20marrow%20involvement:%20Potential%20landmarks%20of%20dissemination%20for%20stage%20I-III%20nasopharyngeal%20carcinoma&rft.jtitle=International%20journal%20of%20radiation%20oncology,%20biology,%20physics&rft.au=Cheng,%20Skye%20Hongiun&rft.date=2005-02-01&rft.volume=61&rft.issue=2&rft.spage=456&rft.epage=465&rft.pages=456-465&rft.issn=0360-3016&rft.eissn=1879-355X&rft_id=info:doi/10.1016/j.ijrobp.2004.05.047&rft_dat=%3Cproquest_cross%3E67375499%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67375499&rft_id=info:pmid/15667967&rft_els_id=S0360301604009381&rfr_iscdi=true |