Factors influencing the immune response to foreign antigen expressed in recombinant BCG vaccines

A wide range of recombinant BCG vaccine candidates containing foreign viral, bacterial, parasite or immunomodulatory genetic material have been developed and evaluated, primarily in animal models, for immune response to the foreign antigen. This review considers some of the factors that may influenc...

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Veröffentlicht in:	Vaccine 2005-01, Vol.23 (10), p.1209-1224
Hauptverfasser:	Dennehy, Maureen, Williamson, Anna-Lise
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Animal models Animals Antibody Formation - physiology Antigens - immunology Applied microbiology Bacterial diseases BCG BCG Vaccine - immunology Biological and medical sciences Drug Evaluation, Preclinical Drug Stability Fundamental and applied biological sciences. Psychology Genes Genetic Vectors Human bacterial diseases Humans Immune response Immune system Immunization Immunogenicity Infectious diseases Medical sciences Microbiology Mycobacterium bovis Parasites Recombinant Tuberculosis Tuberculosis and atypical mycobacterial infections Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - immunology
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