Factor V Leiden, prothrombin 20210A and the risk of venous thrombosis among cancer patients
Summary Cancer patients have an increased risk of venous thrombosis (VT). The association of factor V Leiden (FVL) and the prothrombin 20210A variant with VT in cancer patients is not established. We genotyped 101 cancer patients with VT and 101 cancer patients without VT for these polymorphisms. Fi...
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| Veröffentlicht in: | British journal of haematology 2005-02, Vol.128 (3), p.386-388 |
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| container_title | British journal of haematology |
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| creator | Kennedy, Margaret Andreescu, Astrid C. M. Greenblatt, Marc S. Jiang, Hongyu Thomas, Christian A. Chassereau, Laurie Wong, Cheung Durda, Peter Cushman, Mary |
| description | Summary
Cancer patients have an increased risk of venous thrombosis (VT). The association of factor V Leiden (FVL) and the prothrombin 20210A variant with VT in cancer patients is not established. We genotyped 101 cancer patients with VT and 101 cancer patients without VT for these polymorphisms. Five cases and three controls were heterozygous for FVL, yielding an odds ratio of 1·7 (95% confidence interval (CI) 0·3–10·7). Five cases and no controls were heterozygous for prothrombin 20210A, for an odds ratio of 6·7 (95% CI 0·9–infinity). Prothrombin 20210A may be associated with VT risk among cancer patients. |
| doi_str_mv | 10.1111/j.1365-2141.2004.05327.x |
| format | Article |
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Cancer patients have an increased risk of venous thrombosis (VT). The association of factor V Leiden (FVL) and the prothrombin 20210A variant with VT in cancer patients is not established. We genotyped 101 cancer patients with VT and 101 cancer patients without VT for these polymorphisms. Five cases and three controls were heterozygous for FVL, yielding an odds ratio of 1·7 (95% confidence interval (CI) 0·3–10·7). Five cases and no controls were heterozygous for prothrombin 20210A, for an odds ratio of 6·7 (95% CI 0·9–infinity). Prothrombin 20210A may be associated with VT risk among cancer patients.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/j.1365-2141.2004.05327.x</identifier><identifier>PMID: 15667542</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Biological and medical sciences ; Blood and lymphatic vessels ; cancer ; Cardiology. Vascular system ; Case-Control Studies ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Factor V - genetics ; factor V Leiden ; Female ; Genetic Predisposition to Disease ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; Male ; Medical sciences ; Middle Aged ; Neoplasms - complications ; Neoplasms - genetics ; Polymorphism, Genetic ; Prothrombin - genetics ; prothrombin 20210A ; risk factor ; Risk Factors ; venous thrombosis ; Venous Thrombosis - etiology ; Venous Thrombosis - genetics</subject><ispartof>British journal of haematology, 2005-02, Vol.128 (3), p.386-388</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Feb 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4747-5cef20ae0de8c960dfc927787a0e7acfed053f2f825fac15e4885d6f4f020fa73</citedby><cites>FETCH-LOGICAL-c4747-5cef20ae0de8c960dfc927787a0e7acfed053f2f825fac15e4885d6f4f020fa73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2141.2004.05327.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2141.2004.05327.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17105169$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15667542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kennedy, Margaret</creatorcontrib><creatorcontrib>Andreescu, Astrid C. M.</creatorcontrib><creatorcontrib>Greenblatt, Marc S.</creatorcontrib><creatorcontrib>Jiang, Hongyu</creatorcontrib><creatorcontrib>Thomas, Christian A.</creatorcontrib><creatorcontrib>Chassereau, Laurie</creatorcontrib><creatorcontrib>Wong, Cheung</creatorcontrib><creatorcontrib>Durda, Peter</creatorcontrib><creatorcontrib>Cushman, Mary</creatorcontrib><title>Factor V Leiden, prothrombin 20210A and the risk of venous thrombosis among cancer patients</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Cancer patients have an increased risk of venous thrombosis (VT). The association of factor V Leiden (FVL) and the prothrombin 20210A variant with VT in cancer patients is not established. We genotyped 101 cancer patients with VT and 101 cancer patients without VT for these polymorphisms. Five cases and three controls were heterozygous for FVL, yielding an odds ratio of 1·7 (95% confidence interval (CI) 0·3–10·7). Five cases and no controls were heterozygous for prothrombin 20210A, for an odds ratio of 6·7 (95% CI 0·9–infinity). Prothrombin 20210A may be associated with VT risk among cancer patients.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>cancer</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Factor V - genetics</subject><subject>factor V Leiden</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Prothrombin - genetics</subject><subject>prothrombin 20210A</subject><subject>risk factor</subject><subject>Risk Factors</subject><subject>venous thrombosis</subject><subject>Venous Thrombosis - etiology</subject><subject>Venous Thrombosis - genetics</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhq0K1C6FV6gsJDiRdOzYcfbAoa0oBa3UC3DhYLnOuPWS2Fs7C-3b47ArKnHCl7Hkb0a_vyGEMqhZOafrmjWtrDgTrOYAogbZcFU_HJDF34dnZAEAqmIguiPyIuc1AGtAskNyxGTbKin4gny_NHaKiX6jK_Q9hnd0k-J0l-J44wPlwBmcURN6Ot0hTT7_oNHRnxjiNtMdFrPP1Iwx3FJrgsVEN2byGKb8kjx3Zsj4al-PydfLD18urqrV9cdPF2erygolVCUtOg4GocfOLlvonV1ypTplAJWxDvvyO8ddx6UzlkkUXSf71gkHHJxRzTF5u5tbot9vMU969NniMJiAJaduVaOE4KyAr_8B13GbQsmm2bJrmYRGFqjbQTbFnBM6vUl-NOlRM9Czfb3Ws2Q9S9azff3Hvn4orSf7-dubEfunxr3uArzZAyZbM7hUhPn8xClW9tMuC_d-x_3yAz7-dwB9_vlqvjW_Ab9ynsM</recordid><startdate>200502</startdate><enddate>200502</enddate><creator>Kennedy, Margaret</creator><creator>Andreescu, Astrid C. M.</creator><creator>Greenblatt, Marc S.</creator><creator>Jiang, Hongyu</creator><creator>Thomas, Christian A.</creator><creator>Chassereau, Laurie</creator><creator>Wong, Cheung</creator><creator>Durda, Peter</creator><creator>Cushman, Mary</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200502</creationdate><title>Factor V Leiden, prothrombin 20210A and the risk of venous thrombosis among cancer patients</title><author>Kennedy, Margaret ; Andreescu, Astrid C. M. ; Greenblatt, Marc S. ; Jiang, Hongyu ; Thomas, Christian A. ; Chassereau, Laurie ; Wong, Cheung ; Durda, Peter ; Cushman, Mary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4747-5cef20ae0de8c960dfc927787a0e7acfed053f2f825fac15e4885d6f4f020fa73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>cancer</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Factor V - genetics</topic><topic>factor V Leiden</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Prothrombin - genetics</topic><topic>prothrombin 20210A</topic><topic>risk factor</topic><topic>Risk Factors</topic><topic>venous thrombosis</topic><topic>Venous Thrombosis - etiology</topic><topic>Venous Thrombosis - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kennedy, Margaret</creatorcontrib><creatorcontrib>Andreescu, Astrid C. M.</creatorcontrib><creatorcontrib>Greenblatt, Marc S.</creatorcontrib><creatorcontrib>Jiang, Hongyu</creatorcontrib><creatorcontrib>Thomas, Christian A.</creatorcontrib><creatorcontrib>Chassereau, Laurie</creatorcontrib><creatorcontrib>Wong, Cheung</creatorcontrib><creatorcontrib>Durda, Peter</creatorcontrib><creatorcontrib>Cushman, Mary</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kennedy, Margaret</au><au>Andreescu, Astrid C. M.</au><au>Greenblatt, Marc S.</au><au>Jiang, Hongyu</au><au>Thomas, Christian A.</au><au>Chassereau, Laurie</au><au>Wong, Cheung</au><au>Durda, Peter</au><au>Cushman, Mary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factor V Leiden, prothrombin 20210A and the risk of venous thrombosis among cancer patients</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2005-02</date><risdate>2005</risdate><volume>128</volume><issue>3</issue><spage>386</spage><epage>388</epage><pages>386-388</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Summary
Cancer patients have an increased risk of venous thrombosis (VT). The association of factor V Leiden (FVL) and the prothrombin 20210A variant with VT in cancer patients is not established. We genotyped 101 cancer patients with VT and 101 cancer patients without VT for these polymorphisms. Five cases and three controls were heterozygous for FVL, yielding an odds ratio of 1·7 (95% confidence interval (CI) 0·3–10·7). Five cases and no controls were heterozygous for prothrombin 20210A, for an odds ratio of 6·7 (95% CI 0·9–infinity). Prothrombin 20210A may be associated with VT risk among cancer patients.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15667542</pmid><doi>10.1111/j.1365-2141.2004.05327.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biological and medical sciences Blood and lymphatic vessels cancer Cardiology. Vascular system Case-Control Studies Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Factor V - genetics factor V Leiden Female Genetic Predisposition to Disease Hematologic and hematopoietic diseases Hematology Humans Male Medical sciences Middle Aged Neoplasms - complications Neoplasms - genetics Polymorphism, Genetic Prothrombin - genetics prothrombin 20210A risk factor Risk Factors venous thrombosis Venous Thrombosis - etiology Venous Thrombosis - genetics |
| title | Factor V Leiden, prothrombin 20210A and the risk of venous thrombosis among cancer patients |
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