IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system

This study investigates the role of type I IL-1 receptor (IL-1R1) in mediating the recruitment of leukocytes into the brain parenchyma in mice. Intracerebroventricular (icv) injection of interleukin IL-1β induced infiltration of leukocytes between 8 and 72 h after the injection. Leukocytes were rare...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2005-03, Vol.19 (2), p.127-137
Hauptverfasser:	Ching, San, He, Lingli, Lai, Wenmin, Quan, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Brain Barrier - immunology Brain - blood supply Brain - immunology Brain - parasitology Cell Movement - immunology Cytokine Interferon gamma Receptor Interferon-gamma - pharmacology Interleukin-1 - genetics Interleukin-1 - pharmacology Interleukin-6 - genetics Interleukin-6 - immunology Interleukin-6 - pharmacology Leukocyte infiltration Leukocytes - cytology Leukocytes - immunology Lymphotoxin-alpha - genetics Lymphotoxin-alpha - immunology Male Mice Mice, Knockout Neuroimmune communication Neuroimmunomodulation - immunology Receptors, Interferon - genetics Receptors, Interferon - immunology Receptors, Interleukin-1 - immunology Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - immunology RNA, Messenger - analysis Trypanosoma brucei brucei Trypanosomiasis, African - immunology Tumor Necrosis Factor-alpha - pharmacology
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