A Novel T Cell Receptor Transgenic Animal Model of Seborrheic Dermatitis-Like Skin Disease

We have characterized a novel animal model of the common inflammatory skin disease seborrheic dermatitis (SD) that involves the expression of the self-specific 2C transgenic T cell receptor on the DBA/2 genetic background. Opportunistic fungal pathogens are present in the primary histological lesion...

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Veröffentlicht in:	Journal of investigative dermatology 2005-01, Vol.124 (1), p.151-159
Hauptverfasser:	Oble, Darryl A., Collett, Elisabeth, Hsieh, Mindy, Ambjørn, Malene, Law, Jennie, Dutz, Jan, Teh, Hung-Sia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Age Factors AIDS-related opportunistic infections animal Animals Antigens - immunology Biological and medical sciences CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - transplantation dermatitis Dermatitis, Seborrheic - genetics Dermatitis, Seborrheic - immunology Dermatitis, Seborrheic - pathology Dermatology dermatomycoses Disease Models, Animal Genetic Predisposition to Disease Human viral diseases Immunocompromised Host - genetics Immunocompromised Host - immunology immunologic deficiency syndromes Infectious diseases Lymphopenia - genetics Lymphopenia - immunology Lymphopenia - pathology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred DBA Mice, Transgenic Mycoses - immunology Mycoses - pathology Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology seborrheic Sexual Maturation Skin involvement in other diseases. Miscellaneous. General aspects transgenic Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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