Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity

Lipopolysaccharide (LPS) from the outer membrane of Gram-negative bacteria belongs to the most potent activators of the mammalian immune system. Its lipid moiety, lipid A, the ‘endotoxic principle' of LPS, carries two negatively charged phosphate groups and six acyl chain residues in a defined...

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