Specific Contributions of Histone Tails and their Acetylation to the Mechanical Stability of Nucleosomes

The distinct contributions of histone tails and their acetylation to nucleosomal stability were examined by mechanical disruption of individual nucleosomes in a single chromatin fiber using an optical trap. Enzymatic removal of H2A/H2B tails primarily decreased the strength of histone–DNA interactio...

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Veröffentlicht in:	Journal of molecular biology 2005-02, Vol.346 (1), p.135-146
Hauptverfasser:	Brower-Toland, Brent, Wacker, David A., Fulbright, Robert M., Lis, John T., Kraus, W. Lee, Wang, Michelle D.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetyation Acetylation Amino Acid Sequence DNA - metabolism Gene Expression Regulation histone tails Histones - chemistry Histones - metabolism Humans Microarray Analysis Molecular Sequence Data nucleosome Nucleosomes - chemistry Nucleosomes - genetics Nucleosomes - metabolism optical trapping single molecule Thermodynamics Transcription, Genetic - genetics
Online-Zugang:	Volltext
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