Insulinoma with Six Islet Cell Tumors Associated with Severe Hypoglycemia
A 43-year-old woman was admitted to hospital due to loss of consciousness. Her fasting plasma glucose and serum immunoreactive insulin levels were 14 mg/dL and 5 μU/mL, respectively. She needed continuous glucose infusion to avoid hypoglycemia. A dynamic abdominal CT scan revealed two hypervascular...
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| Veröffentlicht in: | Internal Medicine 2009, Vol.48(12), pp.1041-1046 |
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| container_issue | 12 |
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| container_title | Internal Medicine |
| container_volume | 48 |
| creator | Ishigaki, Saori Yoshihara, Ai Ohwada, Rina Hizuka, Naomi Hatori, Takashi Furukawa, Toru Nishikawa, Toshio Isozaki, Osamu Takano, Kazue |
| description | A 43-year-old woman was admitted to hospital due to loss of consciousness. Her fasting plasma glucose and serum immunoreactive insulin levels were 14 mg/dL and 5 μU/mL, respectively. She needed continuous glucose infusion to avoid hypoglycemia. A dynamic abdominal CT scan revealed two hypervascular tumors in the pancreas. A pancreatectomy was performed and her blood glucose level was normalized. The pathological examination revealed six insulinomas but we could not find either parathyroid tumors or obvious pituitary tumor, which denied the possibility of multiple endocrine neoplasia type I. However, long-term follow-up will be necessary for monitoring the development of other tumors. |
| doi_str_mv | 10.2169/internalmedicine.48.1837 |
| format | Article |
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Her fasting plasma glucose and serum immunoreactive insulin levels were 14 mg/dL and 5 μU/mL, respectively. She needed continuous glucose infusion to avoid hypoglycemia. A dynamic abdominal CT scan revealed two hypervascular tumors in the pancreas. A pancreatectomy was performed and her blood glucose level was normalized. The pathological examination revealed six insulinomas but we could not find either parathyroid tumors or obvious pituitary tumor, which denied the possibility of multiple endocrine neoplasia type I. However, long-term follow-up will be necessary for monitoring the development of other tumors.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.48.1837</identifier><identifier>PMID: 19525595</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Adult ; Female ; Humans ; hypoglycemia ; Hypoglycemia - etiology ; Insulin - blood ; Insulinoma ; Insulinoma - complications ; Insulinoma - diagnostic imaging ; Insulinoma - surgery ; multifocal tumors ; Pancreatectomy ; Pancreatic Neoplasms - complications ; Pancreatic Neoplasms - diagnostic imaging ; Pancreatic Neoplasms - surgery ; Tomography, X-Ray Computed</subject><ispartof>Internal Medicine, 2009, Vol.48(12), pp.1041-1046</ispartof><rights>2009 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c470t-cc6a9243eadc9910f497005e63207f7f8570a7e2af6ba0e803eeb9fb65d8f6803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19525595$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishigaki, Saori</creatorcontrib><creatorcontrib>Yoshihara, Ai</creatorcontrib><creatorcontrib>Ohwada, Rina</creatorcontrib><creatorcontrib>Hizuka, Naomi</creatorcontrib><creatorcontrib>Hatori, Takashi</creatorcontrib><creatorcontrib>Furukawa, Toru</creatorcontrib><creatorcontrib>Nishikawa, Toshio</creatorcontrib><creatorcontrib>Isozaki, Osamu</creatorcontrib><creatorcontrib>Takano, Kazue</creatorcontrib><title>Insulinoma with Six Islet Cell Tumors Associated with Severe Hypoglycemia</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 43-year-old woman was admitted to hospital due to loss of consciousness. Her fasting plasma glucose and serum immunoreactive insulin levels were 14 mg/dL and 5 μU/mL, respectively. She needed continuous glucose infusion to avoid hypoglycemia. A dynamic abdominal CT scan revealed two hypervascular tumors in the pancreas. A pancreatectomy was performed and her blood glucose level was normalized. The pathological examination revealed six insulinomas but we could not find either parathyroid tumors or obvious pituitary tumor, which denied the possibility of multiple endocrine neoplasia type I. However, long-term follow-up will be necessary for monitoring the development of other tumors.</description><subject>Adult</subject><subject>Female</subject><subject>Humans</subject><subject>hypoglycemia</subject><subject>Hypoglycemia - etiology</subject><subject>Insulin - blood</subject><subject>Insulinoma</subject><subject>Insulinoma - complications</subject><subject>Insulinoma - diagnostic imaging</subject><subject>Insulinoma - surgery</subject><subject>multifocal tumors</subject><subject>Pancreatectomy</subject><subject>Pancreatic Neoplasms - complications</subject><subject>Pancreatic Neoplasms - diagnostic imaging</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Tomography, X-Ray Computed</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMtOwzAQRS0EoqXwCygrdil-xLG9rCqgkSp1QVlbjjtpXeVR7ATo35OqEUiIzYxGc-6d0UUoInhKSaoeXd2Cr01ZwcZZV8M0kVMimbhAY8ISFQvK-CUaY0VkTPsyQjch7DFmUih6jUZEccq54mOUZXXoSlc3lYk-XbuLXt1XlIUS2mgOZRmtu6rxIZqF0FhnWtgMFHyAh2hxPDTb8mihcuYWXRWmDHA39Al6e35azxfxcvWSzWfL2CYCt7G1qVE0YWA2VimCi0QJjDmkjGJRiEJygY0Aaoo0NxgkZgC5KvKUb2SR9uMEPZx9D7557yC0unLB9r-aGpou6FQwQRUXPSjPoPVNCB4KffCuMv6oCdanGPXfGHUi9SnGXno_3OjyfvkrHHLrgdUZ2IfWbOEHML51toT_nelQCU7ID2l3xmuo2TeJjZGd</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Ishigaki, Saori</creator><creator>Yoshihara, Ai</creator><creator>Ohwada, Rina</creator><creator>Hizuka, Naomi</creator><creator>Hatori, Takashi</creator><creator>Furukawa, Toru</creator><creator>Nishikawa, Toshio</creator><creator>Isozaki, Osamu</creator><creator>Takano, Kazue</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090101</creationdate><title>Insulinoma with Six Islet Cell Tumors Associated with Severe Hypoglycemia</title><author>Ishigaki, Saori ; Yoshihara, Ai ; Ohwada, Rina ; Hizuka, Naomi ; Hatori, Takashi ; Furukawa, Toru ; Nishikawa, Toshio ; Isozaki, Osamu ; Takano, Kazue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-cc6a9243eadc9910f497005e63207f7f8570a7e2af6ba0e803eeb9fb65d8f6803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Female</topic><topic>Humans</topic><topic>hypoglycemia</topic><topic>Hypoglycemia - etiology</topic><topic>Insulin - blood</topic><topic>Insulinoma</topic><topic>Insulinoma - complications</topic><topic>Insulinoma - diagnostic imaging</topic><topic>Insulinoma - surgery</topic><topic>multifocal tumors</topic><topic>Pancreatectomy</topic><topic>Pancreatic Neoplasms - complications</topic><topic>Pancreatic Neoplasms - diagnostic imaging</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishigaki, Saori</creatorcontrib><creatorcontrib>Yoshihara, Ai</creatorcontrib><creatorcontrib>Ohwada, Rina</creatorcontrib><creatorcontrib>Hizuka, Naomi</creatorcontrib><creatorcontrib>Hatori, Takashi</creatorcontrib><creatorcontrib>Furukawa, Toru</creatorcontrib><creatorcontrib>Nishikawa, Toshio</creatorcontrib><creatorcontrib>Isozaki, Osamu</creatorcontrib><creatorcontrib>Takano, Kazue</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishigaki, Saori</au><au>Yoshihara, Ai</au><au>Ohwada, Rina</au><au>Hizuka, Naomi</au><au>Hatori, Takashi</au><au>Furukawa, Toru</au><au>Nishikawa, Toshio</au><au>Isozaki, Osamu</au><au>Takano, Kazue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulinoma with Six Islet Cell Tumors Associated with Severe Hypoglycemia</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. 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| ispartof | Internal Medicine, 2009, Vol.48(12), pp.1041-1046 |
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| source | J-STAGE Free; MEDLINE |
| subjects | Adult Female Humans hypoglycemia Hypoglycemia - etiology Insulin - blood Insulinoma Insulinoma - complications Insulinoma - diagnostic imaging Insulinoma - surgery multifocal tumors Pancreatectomy Pancreatic Neoplasms - complications Pancreatic Neoplasms - diagnostic imaging Pancreatic Neoplasms - surgery Tomography, X-Ray Computed |
| title | Insulinoma with Six Islet Cell Tumors Associated with Severe Hypoglycemia |
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