Head-up tilt induced syncope and adenosine A2A receptor gene polymorphism
Aims High adenosine plasma levels and high expression of adenosine A2A receptors are observed in patients with unexplained syncope and a positive head-up tilt test (HUT). This study aimed to evaluate the single nucleotide polymorphism (SNP) (c.1364 T>C) which is the most commonly found polymorphi...
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| Veröffentlicht in: | European heart journal 2009-06, Vol.30 (12), p.1510-1515 |
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| creator | Saadjian, Alain Y. Gerolami, Victoria Giorgi, Roch Mercier, Laurence Berge-Lefranc, Jean-Louis Paganelli, Franck Ibrahim, Zouher By, Youlet Guéant, Jean Louis Lévy, Samuel Guieu, Régis P. |
| description | Aims High adenosine plasma levels and high expression of adenosine A2A receptors are observed in patients with unexplained syncope and a positive head-up tilt test (HUT). This study aimed to evaluate the single nucleotide polymorphism (SNP) (c.1364 T>C) which is the most commonly found polymorphism in the A2A receptor gene, in patients with unexplained syncope undergoing HUT. Methods and results One hundred and five patients with unexplained syncope who underwent HUT were included. Fifty-two had a positive test. Receptor genotype determinations were performed in patients and in 121 healthy subjects. Genotype (TT, CC, TC) was determined from DNA leucocytes. The distribution of the polymorphism showed significant (P < 0.0001) difference when the results of HUT were analysed. Fifty-two per cent of patients with a positive HUT had a CC genotype and 34.6% a TC genotype, whereas 13.2% of the patients with a negative HUT had a CC genotype and 71.7% a TC genotype. Patients with a CC genotype had a higher incidence of spontaneous syncopal episodes. Conclusion In patients with unexplained syncope, a significant association between high incidence of syncopal episodes, positive HUT, and the presence of the CC variant in the adenosine A2A receptor gene was elicited. |
| doi_str_mv | 10.1093/eurheartj/ehp126 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67372516</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/eurheartj/ehp126</oup_id><sourcerecordid>67372516</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2886-4e319460c6fa488b22498ef7f1344f10732bffa8417e84e30d28eb59327c254a3</originalsourceid><addsrcrecordid>eNqN0E1v1DAQBmALUdGlcOeEcqEXlNbjrzjHpWq7lSoh8VlxsbzOmE1JYmMnEvvvCWS1XDmNNHpmRvMS8groBdCaX-KUdmjT-HiJuwhMPSErkIyVtRLyKVlRqGWplH44Jc9zfqSUagXqGTmFmmuloFqRuw3appxiMbbdWLRDMzlsirwfXIhY2KEpbINDyO2AxZqti4QO4xhS8R3nTgzdvg8p7trcvyAn3nYZXx7qGfl8c_3palPev7-9u1rfl45prUqBHGqhqFPeCq23jIlao688cCE80IqzrfdWC6hQz5g2TONW1pxVjklh-Rk5X_bGFH5OmEfTt9lh19kBw5SNqnjFJKgZ0gW6FHJO6E1MbW_T3gA1f-Izx_jMEt888vqwe9r22PwbOOQ1gzcHYLOznU92cG0-OgZSAgc9u7eLC1P8n7Plots84q-jt-nH32-k2Tx8MzfvPnyUX_hXc8t_AzZwmSs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67372516</pqid></control><display><type>article</type><title>Head-up tilt induced syncope and adenosine A2A receptor gene polymorphism</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Saadjian, Alain Y. ; Gerolami, Victoria ; Giorgi, Roch ; Mercier, Laurence ; Berge-Lefranc, Jean-Louis ; Paganelli, Franck ; Ibrahim, Zouher ; By, Youlet ; Guéant, Jean Louis ; Lévy, Samuel ; Guieu, Régis P.</creator><creatorcontrib>Saadjian, Alain Y. ; Gerolami, Victoria ; Giorgi, Roch ; Mercier, Laurence ; Berge-Lefranc, Jean-Louis ; Paganelli, Franck ; Ibrahim, Zouher ; By, Youlet ; Guéant, Jean Louis ; Lévy, Samuel ; Guieu, Régis P.</creatorcontrib><description>Aims High adenosine plasma levels and high expression of adenosine A2A receptors are observed in patients with unexplained syncope and a positive head-up tilt test (HUT). This study aimed to evaluate the single nucleotide polymorphism (SNP) (c.1364 T>C) which is the most commonly found polymorphism in the A2A receptor gene, in patients with unexplained syncope undergoing HUT. Methods and results One hundred and five patients with unexplained syncope who underwent HUT were included. Fifty-two had a positive test. Receptor genotype determinations were performed in patients and in 121 healthy subjects. Genotype (TT, CC, TC) was determined from DNA leucocytes. The distribution of the polymorphism showed significant (P < 0.0001) difference when the results of HUT were analysed. Fifty-two per cent of patients with a positive HUT had a CC genotype and 34.6% a TC genotype, whereas 13.2% of the patients with a negative HUT had a CC genotype and 71.7% a TC genotype. Patients with a CC genotype had a higher incidence of spontaneous syncopal episodes. Conclusion In patients with unexplained syncope, a significant association between high incidence of syncopal episodes, positive HUT, and the presence of the CC variant in the adenosine A2A receptor gene was elicited.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehp126</identifier><identifier>PMID: 19386617</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>A2A adenosine receptors ; Adenosine ; Adolescent ; Adult ; Aged ; Biological and medical sciences ; Cardiology. Vascular system ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Female ; Genes ; Genetic Predisposition to Disease - genetics ; Genotype ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Polymorphism, Single Nucleotide - genetics ; Receptor, Adenosine A2A - genetics ; Syncope ; Syncope - genetics ; Tilt-Table Test ; Young Adult</subject><ispartof>European heart journal, 2009-06, Vol.30 (12), p.1510-1515</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2886-4e319460c6fa488b22498ef7f1344f10732bffa8417e84e30d28eb59327c254a3</citedby><cites>FETCH-LOGICAL-c2886-4e319460c6fa488b22498ef7f1344f10732bffa8417e84e30d28eb59327c254a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21551318$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19386617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saadjian, Alain Y.</creatorcontrib><creatorcontrib>Gerolami, Victoria</creatorcontrib><creatorcontrib>Giorgi, Roch</creatorcontrib><creatorcontrib>Mercier, Laurence</creatorcontrib><creatorcontrib>Berge-Lefranc, Jean-Louis</creatorcontrib><creatorcontrib>Paganelli, Franck</creatorcontrib><creatorcontrib>Ibrahim, Zouher</creatorcontrib><creatorcontrib>By, Youlet</creatorcontrib><creatorcontrib>Guéant, Jean Louis</creatorcontrib><creatorcontrib>Lévy, Samuel</creatorcontrib><creatorcontrib>Guieu, Régis P.</creatorcontrib><title>Head-up tilt induced syncope and adenosine A2A receptor gene polymorphism</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Aims High adenosine plasma levels and high expression of adenosine A2A receptors are observed in patients with unexplained syncope and a positive head-up tilt test (HUT). This study aimed to evaluate the single nucleotide polymorphism (SNP) (c.1364 T>C) which is the most commonly found polymorphism in the A2A receptor gene, in patients with unexplained syncope undergoing HUT. Methods and results One hundred and five patients with unexplained syncope who underwent HUT were included. Fifty-two had a positive test. Receptor genotype determinations were performed in patients and in 121 healthy subjects. Genotype (TT, CC, TC) was determined from DNA leucocytes. The distribution of the polymorphism showed significant (P < 0.0001) difference when the results of HUT were analysed. Fifty-two per cent of patients with a positive HUT had a CC genotype and 34.6% a TC genotype, whereas 13.2% of the patients with a negative HUT had a CC genotype and 71.7% a TC genotype. Patients with a CC genotype had a higher incidence of spontaneous syncopal episodes. Conclusion In patients with unexplained syncope, a significant association between high incidence of syncopal episodes, positive HUT, and the presence of the CC variant in the adenosine A2A receptor gene was elicited.</description><subject>A2A adenosine receptors</subject><subject>Adenosine</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Receptor, Adenosine A2A - genetics</subject><subject>Syncope</subject><subject>Syncope - genetics</subject><subject>Tilt-Table Test</subject><subject>Young Adult</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0E1v1DAQBmALUdGlcOeEcqEXlNbjrzjHpWq7lSoh8VlxsbzOmE1JYmMnEvvvCWS1XDmNNHpmRvMS8groBdCaX-KUdmjT-HiJuwhMPSErkIyVtRLyKVlRqGWplH44Jc9zfqSUagXqGTmFmmuloFqRuw3appxiMbbdWLRDMzlsirwfXIhY2KEpbINDyO2AxZqti4QO4xhS8R3nTgzdvg8p7trcvyAn3nYZXx7qGfl8c_3palPev7-9u1rfl45prUqBHGqhqFPeCq23jIlao688cCE80IqzrfdWC6hQz5g2TONW1pxVjklh-Rk5X_bGFH5OmEfTt9lh19kBw5SNqnjFJKgZ0gW6FHJO6E1MbW_T3gA1f-Izx_jMEt888vqwe9r22PwbOOQ1gzcHYLOznU92cG0-OgZSAgc9u7eLC1P8n7Plots84q-jt-nH32-k2Tx8MzfvPnyUX_hXc8t_AzZwmSs</recordid><startdate>200906</startdate><enddate>200906</enddate><creator>Saadjian, Alain Y.</creator><creator>Gerolami, Victoria</creator><creator>Giorgi, Roch</creator><creator>Mercier, Laurence</creator><creator>Berge-Lefranc, Jean-Louis</creator><creator>Paganelli, Franck</creator><creator>Ibrahim, Zouher</creator><creator>By, Youlet</creator><creator>Guéant, Jean Louis</creator><creator>Lévy, Samuel</creator><creator>Guieu, Régis P.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200906</creationdate><title>Head-up tilt induced syncope and adenosine A2A receptor gene polymorphism</title><author>Saadjian, Alain Y. ; Gerolami, Victoria ; Giorgi, Roch ; Mercier, Laurence ; Berge-Lefranc, Jean-Louis ; Paganelli, Franck ; Ibrahim, Zouher ; By, Youlet ; Guéant, Jean Louis ; Lévy, Samuel ; Guieu, Régis P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2886-4e319460c6fa488b22498ef7f1344f10732bffa8417e84e30d28eb59327c254a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>A2A adenosine receptors</topic><topic>Adenosine</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Female</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Receptor, Adenosine A2A - genetics</topic><topic>Syncope</topic><topic>Syncope - genetics</topic><topic>Tilt-Table Test</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saadjian, Alain Y.</creatorcontrib><creatorcontrib>Gerolami, Victoria</creatorcontrib><creatorcontrib>Giorgi, Roch</creatorcontrib><creatorcontrib>Mercier, Laurence</creatorcontrib><creatorcontrib>Berge-Lefranc, Jean-Louis</creatorcontrib><creatorcontrib>Paganelli, Franck</creatorcontrib><creatorcontrib>Ibrahim, Zouher</creatorcontrib><creatorcontrib>By, Youlet</creatorcontrib><creatorcontrib>Guéant, Jean Louis</creatorcontrib><creatorcontrib>Lévy, Samuel</creatorcontrib><creatorcontrib>Guieu, Régis P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saadjian, Alain Y.</au><au>Gerolami, Victoria</au><au>Giorgi, Roch</au><au>Mercier, Laurence</au><au>Berge-Lefranc, Jean-Louis</au><au>Paganelli, Franck</au><au>Ibrahim, Zouher</au><au>By, Youlet</au><au>Guéant, Jean Louis</au><au>Lévy, Samuel</au><au>Guieu, Régis P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Head-up tilt induced syncope and adenosine A2A receptor gene polymorphism</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2009-06</date><risdate>2009</risdate><volume>30</volume><issue>12</issue><spage>1510</spage><epage>1515</epage><pages>1510-1515</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Aims High adenosine plasma levels and high expression of adenosine A2A receptors are observed in patients with unexplained syncope and a positive head-up tilt test (HUT). This study aimed to evaluate the single nucleotide polymorphism (SNP) (c.1364 T>C) which is the most commonly found polymorphism in the A2A receptor gene, in patients with unexplained syncope undergoing HUT. Methods and results One hundred and five patients with unexplained syncope who underwent HUT were included. Fifty-two had a positive test. Receptor genotype determinations were performed in patients and in 121 healthy subjects. Genotype (TT, CC, TC) was determined from DNA leucocytes. The distribution of the polymorphism showed significant (P < 0.0001) difference when the results of HUT were analysed. Fifty-two per cent of patients with a positive HUT had a CC genotype and 34.6% a TC genotype, whereas 13.2% of the patients with a negative HUT had a CC genotype and 71.7% a TC genotype. Patients with a CC genotype had a higher incidence of spontaneous syncopal episodes. Conclusion In patients with unexplained syncope, a significant association between high incidence of syncopal episodes, positive HUT, and the presence of the CC variant in the adenosine A2A receptor gene was elicited.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>19386617</pmid><doi>10.1093/eurheartj/ehp126</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | A2A adenosine receptors Adenosine Adolescent Adult Aged Biological and medical sciences Cardiology. Vascular system Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Female Genes Genetic Predisposition to Disease - genetics Genotype Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Polymorphism, Single Nucleotide - genetics Receptor, Adenosine A2A - genetics Syncope Syncope - genetics Tilt-Table Test Young Adult |
| title | Head-up tilt induced syncope and adenosine A2A receptor gene polymorphism |
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