High-performance liquid chromatographic-tandem mass spectrometric method for the determination of clemastine in human plasma

A highly sensitive high-performance liquid chromatographic-tandem mass spectrometric method (HPLC–MS–MS) has been developed to quantitate clemastine in human plasma for the purpose of pharmacokinetic studies. Sample preparation was carried out by liquid–liquid extraction using deuterated clemastine...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2005-02, Vol.816 (1), p.153-159
Hauptverfasser:	Horváth, Viola, Tolokán, Antal, Egresi, Andrea, Pap, Tímea, Horvai, George, Balogh-Nemes, Katalin, Klebovich, Imre
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Antihistamine Biological and medical sciences Chromatography, High Pressure Liquid - methods Clemastine Clemastine - blood Clemastine - pharmacokinetics Deuterium Drug Stability Fundamental and applied biological sciences. Psychology General pharmacology High-performance liquid chromatography-tandem mass spectrometry Histamine H1 Antagonists - blood Histamine H1 Antagonists - pharmacokinetics Humans Male Medical sciences Pharmacology. Drug treatments Reference Standards Reproducibility of Results Spectrometry, Mass, Electrospray Ionization - methods Therapeutic Equivalency
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