High-performance liquid chromatographic-tandem mass spectrometric method for the determination of clemastine in human plasma
A highly sensitive high-performance liquid chromatographic-tandem mass spectrometric method (HPLC–MS–MS) has been developed to quantitate clemastine in human plasma for the purpose of pharmacokinetic studies. Sample preparation was carried out by liquid–liquid extraction using deuterated clemastine...
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| Veröffentlicht in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2005-02, Vol.816 (1), p.153-159 |
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| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
| container_volume | 816 |
| creator | Horváth, Viola Tolokán, Antal Egresi, Andrea Pap, Tímea Horvai, George Balogh-Nemes, Katalin Klebovich, Imre |
| description | A highly sensitive high-performance liquid chromatographic-tandem mass spectrometric method (HPLC–MS–MS) has been developed to quantitate clemastine in human plasma for the purpose of pharmacokinetic studies. Sample preparation was carried out by liquid–liquid extraction using deuterated clemastine as an internal standard. Chromatographic separation used a C18 reversed phase polymer column giving an extremely fast total run time of 2
min. The method was validated and used for the bioequivalence study of clemastine tablets in healthy male volunteers (
n
=
28). The lower limit of detection proved to be 0.01
ng/ml for clemastine. |
| doi_str_mv | 10.1016/j.jchromb.2004.11.025 |
| format | Article |
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min. The method was validated and used for the bioequivalence study of clemastine tablets in healthy male volunteers (
n
=
28). The lower limit of detection proved to be 0.01
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min. The method was validated and used for the bioequivalence study of clemastine tablets in healthy male volunteers (
n
=
28). The lower limit of detection proved to be 0.01
ng/ml for clemastine.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Antihistamine</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Clemastine</subject><subject>Clemastine - blood</subject><subject>Clemastine - pharmacokinetics</subject><subject>Deuterium</subject><subject>Drug Stability</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>High-performance liquid chromatography-tandem mass spectrometry</subject><subject>Histamine H1 Antagonists - blood</subject><subject>Histamine H1 Antagonists - pharmacokinetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Reference Standards</subject><subject>Reproducibility of Results</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Therapeutic Equivalency</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtrFjEUhoMotlZ_gpKN7mbMdS4rkaJWKLhRcBcyyUknH5PJNMkIgj_e1G-gS1cnkOd9T3iC0GtKWkpo9_7UnsycYphaRohoKW0Jk0_QJR163vC--_m0nmVPGsI4u0Avcj4RQnvS8-fogsquE1zIS_Tnxt_NzQbJxRT0agAv_n73Fv8r1yXeJb3N3jRFrxYCDjpnnDcwpV5DSd7gOuZocS3AZQZsoUAKftXFxxVHh80CNVX8CtiveN7rGrwtOgf9Ej1zesnw6phX6MfnT9-vb5rbb1--Xn-8bYxgrDRyZJYMzFIzjMRpQ8dxsBPVVlAzcjkB15qxgTo3koHaaWJCgu16Pjg-dgL4FXp37t1SvN8hFxV8NrAseoW4Z1XRnnHBKijPoEkx5wRObckHnX4rStSDdnVSh3b1oF1Rqqr2mntzLNinAPYxdXiuwNsD0NnoxaWq2udHrhOS8p5U7sOZg6rjl4eksvFQv8X6VJ0rG_1_nvIXkcOmWg</recordid><startdate>20050225</startdate><enddate>20050225</enddate><creator>Horváth, Viola</creator><creator>Tolokán, Antal</creator><creator>Egresi, Andrea</creator><creator>Pap, Tímea</creator><creator>Horvai, George</creator><creator>Balogh-Nemes, Katalin</creator><creator>Klebovich, Imre</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050225</creationdate><title>High-performance liquid chromatographic-tandem mass spectrometric method for the determination of clemastine in human plasma</title><author>Horváth, Viola ; Tolokán, Antal ; Egresi, Andrea ; Pap, Tímea ; Horvai, George ; Balogh-Nemes, Katalin ; Klebovich, Imre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-592d082d1c890fac1998db1ad41c935be3aa2281ff9081dbb245ed6738f3964e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Antihistamine</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Clemastine</topic><topic>Clemastine - blood</topic><topic>Clemastine - pharmacokinetics</topic><topic>Deuterium</topic><topic>Drug Stability</topic><topic>Fundamental and applied biological sciences. 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B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2005-02-25</date><risdate>2005</risdate><volume>816</volume><issue>1</issue><spage>153</spage><epage>159</epage><pages>153-159</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>A highly sensitive high-performance liquid chromatographic-tandem mass spectrometric method (HPLC–MS–MS) has been developed to quantitate clemastine in human plasma for the purpose of pharmacokinetic studies. Sample preparation was carried out by liquid–liquid extraction using deuterated clemastine as an internal standard. Chromatographic separation used a C18 reversed phase polymer column giving an extremely fast total run time of 2
min. The method was validated and used for the bioequivalence study of clemastine tablets in healthy male volunteers (
n
=
28). The lower limit of detection proved to be 0.01
ng/ml for clemastine.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15664345</pmid><doi>10.1016/j.jchromb.2004.11.025</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-02, Vol.816 (1), p.153-159 |
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| subjects | Analysis Analytical, structural and metabolic biochemistry Antihistamine Biological and medical sciences Chromatography, High Pressure Liquid - methods Clemastine Clemastine - blood Clemastine - pharmacokinetics Deuterium Drug Stability Fundamental and applied biological sciences. Psychology General pharmacology High-performance liquid chromatography-tandem mass spectrometry Histamine H1 Antagonists - blood Histamine H1 Antagonists - pharmacokinetics Humans Male Medical sciences Pharmacology. Drug treatments Reference Standards Reproducibility of Results Spectrometry, Mass, Electrospray Ionization - methods Therapeutic Equivalency |
| title | High-performance liquid chromatographic-tandem mass spectrometric method for the determination of clemastine in human plasma |
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