The actin-binding protein profilin I is localized at synaptic sites in an activity-regulated manner

Morphological changes at synaptic specializations have been implicated in regulating synaptic strength. Actin turnover at dendritic spines is regulated by neuronal activity and contributes to spine size, shape and motility. The reorganization of actin filaments requires profilins, which stimulate ac...

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Veröffentlicht in:	The European journal of neuroscience 2005-01, Vol.21 (1), p.15-25
Hauptverfasser:	Neuhoff, Henrike, Sassoè-Pognetto, Marco, Panzanelli, Patrizia, Maas, Christoph, Witke, Walter, Kneussel, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	actin activity-dependent Adaptor Proteins, Signal Transducing - metabolism alpha Catenin Animals Animals, Newborn Brain - anatomy & histology Brain - metabolism Carrier Proteins - metabolism Cell Count - methods Cells, Cultured Contractile Proteins - metabolism Cytoskeletal Proteins - metabolism dendritic spine Dendritic Spines - drug effects Dendritic Spines - metabolism Dendritic Spines - ultrastructure Disks Large Homolog 4 Protein Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Green Fluorescent Proteins - metabolism Guanylate Kinases Hippocampus - cytology Hippocampus - metabolism Immunohistochemistry - methods Intracellular Signaling Peptides and Proteins Membrane Proteins - metabolism Mice Mice, Inbred C57BL Microfilament Proteins - metabolism Microscopy, Immunoelectron - methods Nerve Tissue Proteins - metabolism Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Neurons - cytology Neurons - drug effects Neurons - metabolism Potassium Chloride - pharmacology profilin Profilins Statistics, Nonparametric synapse Synapses - drug effects Synapses - metabolism Synapses - ultrastructure Synaptophysin - metabolism
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