Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts
Byrsonima crassa Niedenzu (IK) (Malpighiaceae) is used in Brazilian folk medicine for the treatment of diseases related mainly to gastric ulcers. In this study, we evaluated the potential antiulcerogenic effect of three different extracts obtained from the leaves of Byrsonima crassa namely hydrometh...
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| Veröffentlicht in: | Journal of ethnopharmacology 2005-02, Vol.97 (1), p.1-6 |
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| creator | Sannomiya, M. Fonseca, Vitor B. da Silva, M.A. Rocha, L.R.M. dos Santos, L.C. Hiruma-Lima, C.A. Souza Brito, A.R.M. Vilegas, W. |
| description | Byrsonima crassa Niedenzu (IK) (Malpighiaceae) is used in Brazilian folk medicine for the treatment of diseases related mainly to gastric ulcers. In this study, we evaluated the potential antiulcerogenic effect of three different extracts obtained from the leaves of
Byrsonima crassa namely hydromethanolic (80% MeOH), methanolic (MeOH) and chloroformic extracts (CHCl
3). The oral administration (250, 500 and 1000
mg/kg) of all the extracts reduced the formation of lesions associated with HCl/ethanol administration in mice. The 80% MeOH extract significantly reduced the incidence of gastric lesions by 74, 78 and 92% at doses of 250, 500 and 1000
mg/kg, respectively (
P
<
0.01). The MeOH extract reduced the ulceration by 93 and 99% only at the doses of 500 and 1000
mg/kg (
P
<
0.01). The lower gastroprotective action (69%) was observed when animals were treated with CHCl
3 extract at the dose of 1000
mg/kg (
P
<
0.01). Phytochemical investigation of
Byrsonima crassa afforded five known substances: quercetin-3-
O-β-
d-galactopyranoside, quercetin-3-
O-α-
l-arabinopyranoside, the biflavonoid amentoflavone, (+)-catechin and (−)-epicatechin. The presence of these phenolic compounds may probably explain the antiulcerogenic effect of the extracts of
Byrsonima crassa leaves. |
| doi_str_mv | 10.1016/j.jep.2004.09.053 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67371256</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874104005197</els_id><sourcerecordid>67371256</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-fba630094d17f76d7b7b55ca092338b540c5d06966ab1f696876b2b9dc9c8ab03</originalsourceid><addsrcrecordid>eNp90MFu1DAQBmALgei28ABcIBe4JR3HsZ2IE1QUKhX1AD1bY3tSeZWNFzu76r49rnal3noYzeWb0czP2AcODQeuLtfNmrZNC9A1MDQgxSu24r1uay21eM1WIHRf97rjZ-w85zUAaN7BW3bGpZJtq_SK_b6ecB_nGHyucPallrCbHKX4QHNwFbol7MNyqMYUN9X3Q8pxDhusXMKcsZoI95QrelxSkfkdezPilOn9qV-w--sff69-1bd3P2-uvt3WrgO51KNFJQCGznM9auW11VZKhzC0QvRWduCkBzUohZaPpfda2dYO3g2uRwvign057t2m-G9HeTGbkB1NE84Ud9koLTRvpSqQH6FLMedEo9mmcn46GA7mKUOzNiVD85ShgcGUDMvMx9Pynd2Qf544hVbA5xPA7HAaE84u5GenOiVByuI-Hd2I0eBDKub-TwtcAC_Pl_-K-HoUVMLaB0omu0CzIx8SucX4GF449D-tvpht</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67371256</pqid></control><display><type>article</type><title>Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Sannomiya, M. ; Fonseca, Vitor B. ; da Silva, M.A. ; Rocha, L.R.M. ; dos Santos, L.C. ; Hiruma-Lima, C.A. ; Souza Brito, A.R.M. ; Vilegas, W.</creator><creatorcontrib>Sannomiya, M. ; Fonseca, Vitor B. ; da Silva, M.A. ; Rocha, L.R.M. ; dos Santos, L.C. ; Hiruma-Lima, C.A. ; Souza Brito, A.R.M. ; Vilegas, W.</creatorcontrib><description>Byrsonima crassa Niedenzu (IK) (Malpighiaceae) is used in Brazilian folk medicine for the treatment of diseases related mainly to gastric ulcers. In this study, we evaluated the potential antiulcerogenic effect of three different extracts obtained from the leaves of
Byrsonima crassa namely hydromethanolic (80% MeOH), methanolic (MeOH) and chloroformic extracts (CHCl
3). The oral administration (250, 500 and 1000
mg/kg) of all the extracts reduced the formation of lesions associated with HCl/ethanol administration in mice. The 80% MeOH extract significantly reduced the incidence of gastric lesions by 74, 78 and 92% at doses of 250, 500 and 1000
mg/kg, respectively (
P
<
0.01). The MeOH extract reduced the ulceration by 93 and 99% only at the doses of 500 and 1000
mg/kg (
P
<
0.01). The lower gastroprotective action (69%) was observed when animals were treated with CHCl
3 extract at the dose of 1000
mg/kg (
P
<
0.01). Phytochemical investigation of
Byrsonima crassa afforded five known substances: quercetin-3-
O-β-
d-galactopyranoside, quercetin-3-
O-α-
l-arabinopyranoside, the biflavonoid amentoflavone, (+)-catechin and (−)-epicatechin. The presence of these phenolic compounds may probably explain the antiulcerogenic effect of the extracts of
Byrsonima crassa leaves.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2004.09.053</identifier><identifier>PMID: 15652267</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; anti-ulcer activity ; Anti-Ulcer Agents - isolation & purification ; Anti-Ulcer Agents - therapeutic use ; Antiulcer activity ; Biological and medical sciences ; Byrsonima ; Byrsonima crassa ; Dose-Response Relationship, Drug ; Flavonoids ; Flavonoids - isolation & purification ; Flavonoids - therapeutic use ; General pharmacology ; leaves ; Male ; Malpighiaceae ; Medical sciences ; medicinal plants ; Mice ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phytochemicals ; plant extracts ; Plant Extracts - isolation & purification ; Plant Extracts - therapeutic use ; Plant Leaves ; Stomach Ulcer - drug therapy ; Stomach Ulcer - pathology ; traditional medicine</subject><ispartof>Journal of ethnopharmacology, 2005-02, Vol.97 (1), p.1-6</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-fba630094d17f76d7b7b55ca092338b540c5d06966ab1f696876b2b9dc9c8ab03</citedby><cites>FETCH-LOGICAL-c405t-fba630094d17f76d7b7b55ca092338b540c5d06966ab1f696876b2b9dc9c8ab03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2004.09.053$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16465055$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15652267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sannomiya, M.</creatorcontrib><creatorcontrib>Fonseca, Vitor B.</creatorcontrib><creatorcontrib>da Silva, M.A.</creatorcontrib><creatorcontrib>Rocha, L.R.M.</creatorcontrib><creatorcontrib>dos Santos, L.C.</creatorcontrib><creatorcontrib>Hiruma-Lima, C.A.</creatorcontrib><creatorcontrib>Souza Brito, A.R.M.</creatorcontrib><creatorcontrib>Vilegas, W.</creatorcontrib><title>Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Byrsonima crassa Niedenzu (IK) (Malpighiaceae) is used in Brazilian folk medicine for the treatment of diseases related mainly to gastric ulcers. In this study, we evaluated the potential antiulcerogenic effect of three different extracts obtained from the leaves of
Byrsonima crassa namely hydromethanolic (80% MeOH), methanolic (MeOH) and chloroformic extracts (CHCl
3). The oral administration (250, 500 and 1000
mg/kg) of all the extracts reduced the formation of lesions associated with HCl/ethanol administration in mice. The 80% MeOH extract significantly reduced the incidence of gastric lesions by 74, 78 and 92% at doses of 250, 500 and 1000
mg/kg, respectively (
P
<
0.01). The MeOH extract reduced the ulceration by 93 and 99% only at the doses of 500 and 1000
mg/kg (
P
<
0.01). The lower gastroprotective action (69%) was observed when animals were treated with CHCl
3 extract at the dose of 1000
mg/kg (
P
<
0.01). Phytochemical investigation of
Byrsonima crassa afforded five known substances: quercetin-3-
O-β-
d-galactopyranoside, quercetin-3-
O-α-
l-arabinopyranoside, the biflavonoid amentoflavone, (+)-catechin and (−)-epicatechin. The presence of these phenolic compounds may probably explain the antiulcerogenic effect of the extracts of
Byrsonima crassa leaves.</description><subject>Animals</subject><subject>anti-ulcer activity</subject><subject>Anti-Ulcer Agents - isolation & purification</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Antiulcer activity</subject><subject>Biological and medical sciences</subject><subject>Byrsonima</subject><subject>Byrsonima crassa</subject><subject>Dose-Response Relationship, Drug</subject><subject>Flavonoids</subject><subject>Flavonoids - isolation & purification</subject><subject>Flavonoids - therapeutic use</subject><subject>General pharmacology</subject><subject>leaves</subject><subject>Male</subject><subject>Malpighiaceae</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Mice</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phytochemicals</subject><subject>plant extracts</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves</subject><subject>Stomach Ulcer - drug therapy</subject><subject>Stomach Ulcer - pathology</subject><subject>traditional medicine</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90MFu1DAQBmALgei28ABcIBe4JR3HsZ2IE1QUKhX1AD1bY3tSeZWNFzu76r49rnal3noYzeWb0czP2AcODQeuLtfNmrZNC9A1MDQgxSu24r1uay21eM1WIHRf97rjZ-w85zUAaN7BW3bGpZJtq_SK_b6ecB_nGHyucPallrCbHKX4QHNwFbol7MNyqMYUN9X3Q8pxDhusXMKcsZoI95QrelxSkfkdezPilOn9qV-w--sff69-1bd3P2-uvt3WrgO51KNFJQCGznM9auW11VZKhzC0QvRWduCkBzUohZaPpfda2dYO3g2uRwvign057t2m-G9HeTGbkB1NE84Ud9koLTRvpSqQH6FLMedEo9mmcn46GA7mKUOzNiVD85ShgcGUDMvMx9Pynd2Qf544hVbA5xPA7HAaE84u5GenOiVByuI-Hd2I0eBDKub-TwtcAC_Pl_-K-HoUVMLaB0omu0CzIx8SucX4GF449D-tvpht</recordid><startdate>20050210</startdate><enddate>20050210</enddate><creator>Sannomiya, M.</creator><creator>Fonseca, Vitor B.</creator><creator>da Silva, M.A.</creator><creator>Rocha, L.R.M.</creator><creator>dos Santos, L.C.</creator><creator>Hiruma-Lima, C.A.</creator><creator>Souza Brito, A.R.M.</creator><creator>Vilegas, W.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050210</creationdate><title>Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts</title><author>Sannomiya, M. ; Fonseca, Vitor B. ; da Silva, M.A. ; Rocha, L.R.M. ; dos Santos, L.C. ; Hiruma-Lima, C.A. ; Souza Brito, A.R.M. ; Vilegas, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-fba630094d17f76d7b7b55ca092338b540c5d06966ab1f696876b2b9dc9c8ab03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>anti-ulcer activity</topic><topic>Anti-Ulcer Agents - isolation & purification</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>Antiulcer activity</topic><topic>Biological and medical sciences</topic><topic>Byrsonima</topic><topic>Byrsonima crassa</topic><topic>Dose-Response Relationship, Drug</topic><topic>Flavonoids</topic><topic>Flavonoids - isolation & purification</topic><topic>Flavonoids - therapeutic use</topic><topic>General pharmacology</topic><topic>leaves</topic><topic>Male</topic><topic>Malpighiaceae</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Mice</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phytochemicals</topic><topic>plant extracts</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves</topic><topic>Stomach Ulcer - drug therapy</topic><topic>Stomach Ulcer - pathology</topic><topic>traditional medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sannomiya, M.</creatorcontrib><creatorcontrib>Fonseca, Vitor B.</creatorcontrib><creatorcontrib>da Silva, M.A.</creatorcontrib><creatorcontrib>Rocha, L.R.M.</creatorcontrib><creatorcontrib>dos Santos, L.C.</creatorcontrib><creatorcontrib>Hiruma-Lima, C.A.</creatorcontrib><creatorcontrib>Souza Brito, A.R.M.</creatorcontrib><creatorcontrib>Vilegas, W.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sannomiya, M.</au><au>Fonseca, Vitor B.</au><au>da Silva, M.A.</au><au>Rocha, L.R.M.</au><au>dos Santos, L.C.</au><au>Hiruma-Lima, C.A.</au><au>Souza Brito, A.R.M.</au><au>Vilegas, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2005-02-10</date><risdate>2005</risdate><volume>97</volume><issue>1</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Byrsonima crassa Niedenzu (IK) (Malpighiaceae) is used in Brazilian folk medicine for the treatment of diseases related mainly to gastric ulcers. In this study, we evaluated the potential antiulcerogenic effect of three different extracts obtained from the leaves of
Byrsonima crassa namely hydromethanolic (80% MeOH), methanolic (MeOH) and chloroformic extracts (CHCl
3). The oral administration (250, 500 and 1000
mg/kg) of all the extracts reduced the formation of lesions associated with HCl/ethanol administration in mice. The 80% MeOH extract significantly reduced the incidence of gastric lesions by 74, 78 and 92% at doses of 250, 500 and 1000
mg/kg, respectively (
P
<
0.01). The MeOH extract reduced the ulceration by 93 and 99% only at the doses of 500 and 1000
mg/kg (
P
<
0.01). The lower gastroprotective action (69%) was observed when animals were treated with CHCl
3 extract at the dose of 1000
mg/kg (
P
<
0.01). Phytochemical investigation of
Byrsonima crassa afforded five known substances: quercetin-3-
O-β-
d-galactopyranoside, quercetin-3-
O-α-
l-arabinopyranoside, the biflavonoid amentoflavone, (+)-catechin and (−)-epicatechin. The presence of these phenolic compounds may probably explain the antiulcerogenic effect of the extracts of
Byrsonima crassa leaves.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15652267</pmid><doi>10.1016/j.jep.2004.09.053</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals anti-ulcer activity Anti-Ulcer Agents - isolation & purification Anti-Ulcer Agents - therapeutic use Antiulcer activity Biological and medical sciences Byrsonima Byrsonima crassa Dose-Response Relationship, Drug Flavonoids Flavonoids - isolation & purification Flavonoids - therapeutic use General pharmacology leaves Male Malpighiaceae Medical sciences medicinal plants Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals plant extracts Plant Extracts - isolation & purification Plant Extracts - therapeutic use Plant Leaves Stomach Ulcer - drug therapy Stomach Ulcer - pathology traditional medicine |
| title | Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts |
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