Effect of adsorbents on the absorption of lansoprazole with surfactant

Lansoprazole (LPZ) is a representative drug that shows a high inter-subject variation of bioavailability (BA). Solid preparation composed of surfactant, adsorbent and LPZ were prepared to improve the dissolution and absorption of LPZ, and the BA of LPZ was measured in rats and dogs. As surfactant, T...

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Veröffentlicht in:	International journal of pharmaceutics 2005-01, Vol.289 (1), p.69-77
Hauptverfasser:	Ito, Yukako, Arai, Harumi, Uchino, Kaori, Iwasaki, Kouji, Shibata, Nobuhito, Takada, Kanji
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Pyridinylmethylsulfinylbenzimidazoles Absorption Absorption - drug effects Administration, Oral Adosorbent Adsorption Animals Area Under Curve Bioavailability Biological and medical sciences Biological Availability Dogs Drug Evaluation, Preclinical - methods Duodenum - drug effects General pharmacology Injections, Intravenous Lansoprazole Male Medical sciences Omeprazole - analogs & derivatives Omeprazole - blood Omeprazole - chemistry Omeprazole - pharmacology Oral administration Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Powders - administration & dosage Powders - chemistry Powders - pharmacokinetics Rats Rats, Wistar Silicon Dioxide - administration & dosage Silicon Dioxide - pharmacokinetics Solutions - administration & dosage Solutions - chemistry Solutions - pharmacokinetics Surface-Active Agents - chemistry Surface-Active Agents - metabolism Surface-Active Agents - pharmacokinetics Surfactant
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